Pleiotrophin Protein (PTN) (AA 33-168) (Fc Tag)

Catalog No. ABIN7092750

Recombinant Pleiotrophin protein expressed in HEK-293 Cells.

Quick Overview for Pleiotrophin Protein (PTN) (AA 33-168) (Fc Tag) (ABIN7092750)

Target: Pleiotrophin (PTN)

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Affinity Measurement (AM), Antibody Drug Assay (ADA), Immunoassay (IA), Screening Assay (ScA)

Purity: The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 33-168

Purification tag / Conjugate: This Pleiotrophin protein is labelled with Fc Tag.

Purpose: Recombinant Human PTN Protein with C-terminal human Fc tag

Specificity: PTN(Gly33-Asp168) hFc(Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Application Details

Application Notes: Extracellular Domain Proteins (ECD) can be used as:

• Immunogens for antibody drug development
• Reagents used for CAR-T positive cell monitoring
• Reagents for antibody screening and functional testing
• Reagents for antibody affinity measurement

Comment:

The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: Pleiotrophin (PTN)

Alternative Name: PTN

Background: HARP,HB-GAM,HBBM,HBGF-8,HBGF8,HBNF,HBNF-1,NEGF1,OSF-1
The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Molecular Weight: predicted molecular mass of 41.4 kDa after removal of the signal peptide.The apparent molecular mass of PTN-hFc is 35-55 kDa due to glycosylation.

UniProt: P21246

Pathways: RTK Signaling