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Wnt5a (show WNT5A Proteins) suppressed osteoblastic differentiation through Ror2/JNK (show MAPK8 Proteins) signaling in periodontal ligament stem cell-like cells.
Data show that receptor tyrosine kinase-like orphan receptor 2 (ROR2) is epigenetically silenced by promoter hypermethylation in colorectal cancer cell lines and in early stages of colorectal neoplasia tissue.
WNT5A (show WNT5A Proteins) and ROR2 are induced by inflammatory mediators through NF-kB and STAT3 (show STAT3 Proteins) transcription factors, and are involved in the migration of human ovarian cancer cell line SKOV-3.
On these bases, we identified that miR (show MLXIP Proteins)-208b targets receptor tyrosine kinase-like orphan receptor 2 gene by which miR (show MLXIP Proteins)-208b can regulate the development of osteosarcoma.
Our findings suggest that receptor tyrosine kinase-like orphan receptor 2 may be an important regulator of epithelial-mesenchymal transition, primarily regulated the non-canonical Wnt (show WNT2 Proteins) signaling pathway in ovarian cancer cells, and may display a promising therapeutic target for ovarian cancer.
Knockdown of Ror2 expression in renal cell carcinoma (show MOK Proteins) cells significantly reduced cell proliferation and induced apoptosis.
found no association between ROR2 staining and poor patient survival
Data show that CD13 (show ANPEP Proteins) anntigen and receptor tyrosine kinase-like orphan receptor 2 (ROR2) identify a cardiac lineage precursor pool that is capable of successful engraftment into the porcine heart.
ROR2 gene mutations are associated with autosomal recessive robinow syndrome.
results corroborated previous findings of Ryk (show RYK Proteins)-mediated Wnt5a (show WNT5A Proteins) effect, and suggested a role for Ror2 in the Wnt5a (show WNT5A Proteins) machinery in glioblastoma
we uncovered cell state plasticity and adhesion dynamics regulated by Ror2, which influenced Ras Homology Family Member A (show CXCL14 Proteins) (RhoA (show RHOA Proteins)) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1 (show ROCK1 Proteins)) activity downstream of Dishevelled-2 (Dvl2 (show DVL2 Proteins)).
Here, the study of two Ror2 mutants connects aberrant germ cell migration to defects in meiosis and supports the diffusion model of meiotic entry.
Although Ror1 (show ROR1 Proteins)-mutant mice show no apparent defects in ureteric bud (UB) formation, Ror1 (show ROR1 Proteins); Ror2-double-mutant mice exhibit either defects in UB outgrowth and branching morphogenesis, associated with the loss of the MM from the UB domain, or ectopic formation of the UB.
The Wnt5a (show WNT5A Proteins)-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-gamma (show IFNG Proteins) in colitis
Non-canonical Wnt5a (show WNT5A Proteins)/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension.
Ror2 plays an important role in mammary gland development in mice.
The activation of Wnt5a (show WNT5A Proteins)-Ror2 signaling in epithelial cells undergoing epithelial-to-mesenchymal transition (EMT (show ITK Proteins)) may play an important role in disrupting TBM via MMP-2 (show MMP2 Proteins) induction during renal fibrosis.
The results indicate an important role of Wnt5a (show WNT5A Proteins)-Ror2 signaling in morphogenesis of the metanephric mesenchyme to ensure proper epithelial tubular formation of the ureteric bud required for kidney development.
This study provides a method to investigate the effects of the Wnt (show WNT2 Proteins) pathway on the fate of mesenchymal stem cells (MSC (show MSC Proteins)) in vivo and for the further improvement of MSC (show MSC Proteins)-based therapies.
Show Ror2 expression is higher in highly metastatic cell line than in low metastatic variant cell line. Our data show that Ror2 is a potential factor in the tumorigenesis and metastasis in a Src (show SRC Proteins)-dependent manner that is negatively regulated by NRAGE (show MAGED1 Proteins).
In the Xenopus embryo, Ptk7 (show PTK7 Proteins) functionally interacts with Ror2 to regulate protocadherin papc (show PCDH8 Proteins) expression and morphogenesis.
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2, which require Wnt5a (show WNT5A Proteins)/Ror2 signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC (show PCDH8 Proteins) signaling via RhoA (show RHOA Proteins) and Wnt5a (show WNT5A Proteins)/Ror2 activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Transcriptional regulation of XPAPC (show PCDH8 Proteins) by XWnt-5A (show WNT5A Proteins) requires the receptor tyrosine kinase Ror2.
demonstrated that this anti-canonical Wnt (show WNT2 Proteins) activity of Del1 is dependent on the Ror2 pathway, which is activated by the non-canonical Wnt (show WNT2 Proteins) ligands
The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.
neurotrophic tyrosine kinase receptor-related 2
, tyrosine-protein kinase transmembrane receptor ROR2
, neurotrophic tyrosine kinase, receptor related 2
, neurotrophic tyrosine kinase, receptor-related 2
, receptor tyrosine kinase-like orphan receptor 2
, tyrosine-protein kinase transmembrane receptor ROR2-like
, LOW QUALITY PROTEIN: tyrosine-protein kinase transmembrane receptor ROR2
, receptor tyrosine kinase Xror2
, receptor tyrosine kinase like orphan receptor 2 L homeolog
, receptor tyrosine kinase-like orphan receptor 2 L homeolog