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Human ROR2 Protein expressed in HEK-293 Cells - ABIN2181706
Liu, Ross, Bodine, Billiard: Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. in Molecular endocrinology (Baltimore, Md.) 2007
Show all 3 references for ABIN2181706
ROR2 gene mutations are associated with autosomal recessive robinow syndrome.
results corroborated previous findings of Ryk (show RYK Proteins)-mediated Wnt5a (show WNT5A Proteins) effect, and suggested a role for Ror2 in the Wnt5a (show WNT5A Proteins) machinery in glioblastoma
Data show that silencing receptor tyrosine kinases (RTKs) ROR2 and ROR1 (show ROR1 Proteins) has a strong inhibitory effect on the ability of ovarian cancer cells to proliferate, migrate and invade.
Wnt5a (show WNT5A Proteins)-Ror2 signaling enhances expression and secretion of CXCL16 (show CXCL16 Proteins) in mesenchymal stem cells thereby activating CXCR6 (show CXCR6 Proteins) expressed on tumor cells to promote proliferation.
the b-catenin-independent WNT (show WNT2 Proteins) score correlated with reduced overall survival only in the metastasized situation . This is in line with the in vitro results of the alternative WNT (show WNT2 Proteins) receptors ROR1 (show ROR1 Proteins) and ROR2, which foster invasion
We present strong evidence that ROR2 could be used as an indicator of poor prognosis and could represent a novel therapeutic target for PDAC.
Findings suggest that high receptor tyrosine kinase (show RET Proteins)-like orphan receptor (show NR1D2 Proteins) (ROR) 2 or proto-oncogene (show RAB1A Proteins) protein Wnt-5A (Wnt5a (show WNT5A Proteins)) expression is associated with poor prognosis in non-small cell lung cancer (NSCLC).
This study identifies an interaction between ROR1 (show ROR1 Proteins) and ROR2 that is required for Wnt5a (show WNT5A Proteins) signaling that promotes leukemia chemotaxis and proliferation.
These data suggest a mechanism where human cytomegalovirus alters the expression of the Wnt receptor ROR2 to alter Wnt5a (show WNT5A Proteins)-mediated signaling and inhibit trophoblast motility
Positive ROR2 and FRAT1 (show FRAT1 Proteins) expression is associated with the progression and poor prognosis of chondrosarcoma.
The Wnt5a (show WNT5A Proteins)-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-gamma (show IFNG Proteins) in colitis
Non-canonical Wnt5a (show WNT5A Proteins)/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension.
Ror2 plays an important role in mammary gland development in mice.
The activation of Wnt5a (show WNT5A Proteins)-Ror2 signaling in epithelial cells undergoing epithelial-to-mesenchymal transition (EMT (show ITK Proteins)) may play an important role in disrupting TBM via MMP-2 (show MMP2 Proteins) induction during renal fibrosis.
The results indicate an important role of Wnt5a (show WNT5A Proteins)-Ror2 signaling in morphogenesis of the metanephric mesenchyme to ensure proper epithelial tubular formation of the ureteric bud required for kidney development.
This study provides a method to investigate the effects of the Wnt (show WNT2 Proteins) pathway on the fate of mesenchymal stem cells (MSC (show MSC Proteins)) in vivo and for the further improvement of MSC (show MSC Proteins)-based therapies.
Show Ror2 expression is higher in highly metastatic cell line than in low metastatic variant cell line. Our data show that Ror2 is a potential factor in the tumorigenesis and metastasis in a Src (show SRC Proteins)-dependent manner that is negatively regulated by NRAGE (show MAGED1 Proteins).
Wnt5a (show WNT5A Proteins)-Ror1 (show ROR1 Proteins) and Wnt5a (show WNT5A Proteins)-Ror2 signaling pathways regulated neurogenesis in the developing neocortex.
A soluble form of Ror2 acted as a decoy receptor of Wnt5a (show WNT5A Proteins) and abrogated bone destruction in mouse arthritis models
These findings suggest that Wnt5a (show WNT5A Proteins)-Ror-Dishevelled (show DVL2 Proteins) signaling constitutes a core noncanonical Wnt (show WNT2 Proteins) pathway that is conserved through evolution and is crucial during embryonic development.
The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.
receptor tyrosine kinase-like orphan receptor 2
, tyrosine-protein kinase transmembrane receptor ROR2
, tyrosine-protein kinase transmembrane receptor ROR2-like
, neurotrophic tyrosine kinase receptor-related 2
, neurotrophic tyrosine kinase, receptor related 2
, neurotrophic tyrosine kinase, receptor-related 2