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Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome
We identified two novel genes, SOS2 and LZTR1 (show LZTR1 Proteins), associated with Noonan syndrome, thereby expanding the molecular spectrum of RASopathies.
multicenter pharmacogenetic study in children (ages 6-11): Data suggest that SNP in SOS2 (rs13379306) in children with growth hormone deficiency is associated with drug resistance to hormone replacement therapy with recombinant human growth hormone.
intracellular Francisella tularensis novicida triggers temporal and early activation of Ras through the SOS2/GrB2/PKCalpha/PKCbetaI quaternary complex; Ras signalling by intracellular F. tularensis is essential for intracellular proliferation in the cytosol
Significant association of single nucleotide polymorphism within three genes--PPARgamma (show PPARG Proteins), SOS2, and PCK1 (show PCK1 Proteins)--with Alzheimer's disease, was confirmed.
Loss of MADD (show ETFA Proteins) expression resulted in reduced Grb2 (show GRB2 Proteins) and Sos1 (show SOS1 Proteins)/2 recruitment to the TNFR1 (show TNFRSF1A Proteins) complex and decreased Ras and MEKK1 (show MAP3K1 Proteins)/2 activation
The increased activity of the PI3K/AKT (show AKT1 Proteins) pathway led to downregulation of the surface receptor CD62L (show SELL Proteins) in Sos-1 (show SOS1 Proteins)/2dKO T cells and a subsequent impairment in T-cell migration.
Absolute counts of mature B and T cells in spleen and peripheral blood were unchanged in single-knockout mutants, while significantly reduced in Sos1 (show SOS1 Proteins)/2 double-knockout mice.
assessed the independent and combined roles for the RasGEFs Sos1 (show SOS1 Proteins), Sos2, and RasGRP1 (show RASGRP1 Proteins) during thymocyte development
Vav1 (show VAV1 Proteins) transduces TCR signals to Ras by controlling recruitment of RasGRP1 (show RASGRP1 Proteins) to the membrane and recruitment of Sos1 (show SOS1 Proteins) and -2 to the transmembrane adapter protein (show GRB10 Proteins) LAT (show LAT Proteins).
Sos2 is dispensable for both NMDA-induced Erk (show EPHB2 Proteins) activation in cortical neuron cultures from neonatal mice, and for LTP (show SCP2 Proteins) induction at the Schaffer-CA1 (show CA1 Proteins) synapses in brain slices from young mice that is known to require NMDA receptor signaling.
mRNA expression increases after chronic clozapine treatment in the prefrontal cortex\\; may play a role in synaptic function
son of sevenless homolog 2
, son of sevenless 1
, guanine nucleotide exchange factor
, guanine nucleotide releasing factor