Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species
Tsc1 is involved in regulation of interactive network between the cilium and the TOR pathway.
TSC1 expression is reduced in two subsets of clear-cell renal cell carcinomas, those with monoallelic VHL (show VHL ELISA Kits) gene inactivation and those with concurrent low HIF-1alpha (show HIF1A ELISA Kits) and high HIF-2alpha (show EPAS1 ELISA Kits) expression.
Repression of TSC1/TSC2 (show TSC2 ELISA Kits) mediated by MeCP2 (show MECP2 ELISA Kits) regulates human embryo lung fibroblast cell differentiation and proliferation.
TSC1 mutation is associated in patients, diagnosed with tuberous sclerosis associated vascular malformation.
Novel TSC1 mutations in Chinese patients with tuberous sclerosis.
Gene expression level of TSC1 is significantly higher in AD patients when compared to normal controls.
Each TBC1D7 (show TBC1D7 ELISA Kits) molecule interacts simultaneously with two parallel TSC1 helices from two TSC1 molecules, suggesting that TBC1D7 (show TBC1D7 ELISA Kits) may stabilize the TSC (show SLC12A3 ELISA Kits) complex by tethering the C-terminal ends of two TSC1 coiled-coils.
IQ/DQ correlates inversely with predicted levels and/or deleterious biochemical effects of mutant TSC1 or TSC2 (show TSC2 ELISA Kits) protein in tuberous sclerosis complex.
AKT3 (show AKT3 ELISA Kits) has a role in prostate cancer proliferation through regulation of Akt (show AKT1 ELISA Kits), B-Raf (show SNRPE ELISA Kits), and TSC1/TSC2 (show TSC2 ELISA Kits)
Tsc1 transgenic mice exhibit an age-dependent seizure pattern sequence mimicking early human tuberous sclerosis complex epilepsy.
PAK2 (show PAK2 ELISA Kits) is a direct effector of TSC1-TSC2 (show TSC2 ELISA Kits)-RHEB (show RHEB ELISA Kits) signaling and a new target for rational drug therapy in TSC (show SLC12A3 ELISA Kits).
suppression of AKT (show AKT1 ELISA Kits) by hyperactivation of mTORC1, inhibition on nuclear ERalpha (show ESR1 ELISA Kits) signaling, and down-regulation of cell-cycle-driving proteins play important roles in the retarded mammary development induced by Tsc1 deletion.
TSC1 knockout mice are lean, glucose intolerant with a decreased activation of protein kinase B (Akt/PKB (show AKT1 ELISA Kits)) targets that regulate glucose transporters in skeletal muscle.
a pivotal role for Tsc1 in regulating various aspects of visual-pathway development, is reported.
Tsc1 plays a critical role in regulating macrophage survival, function and polarization via inhibition of mTORC1 activity.
TSC1-KO results in the accumulation of transitional-1 B cells and progressive losses of B cells as they mature beyond the T1 stage. However, Peyer's patch germinal centers are unimpaired in TSC1-KO mice.
TSC1 deletion led to enhanced mTORC1 signaling in neural crest derived bones and the increase in bone formation is responsible for the aberrantly increased bone mass.
Results describe the development of new vascular mouse model with a conditional knockout allele of Tsc1 with a Darpp32 (show PPP1R1B ELISA Kits)-Cre allele. This mouse displayed accelerated formation of both kidney cystadenomas and paw hemangiosarcomas.
PLK1 (show PLK1 ELISA Kits) protein levels are increased in hamartin and tuberin (show TSC2 ELISA Kits) deficient cells and Lymphangioleiomyomatosis patient-derived specimens, and that this increase is rapamycin-sensitive.
This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants.
tuberous sclerosis 1 protein
, tuberous sclerosis 1
, tumor suppressor
, tuberous sclerosis 1 protein homolog
, chromosome 9 TSC1