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This is the first report using an animal model to show interactions between tsc2, mTORC1 and p53 (show TP53 ELISA Kits) during tumorigenesis.
These results demonstrate a highly conserved role of tsc2 in zebrafish and establish a new animal model for studies of Tuberous sclerosis complex.
By interfering with TSC (show SLC12A3 ELISA Kits)-Rheb (show RHEB ELISA Kits) complex, arginine relieves allosteric inhibition of Rheb (show RHEB ELISA Kits) by TSC (show SLC12A3 ELISA Kits). Arginine cooperates with growth factor signaling which further promotes dissociation of TSC2 from lysosomes and activation of mTORC1.
IQ/DQ correlates inversely with predicted levels and/or deleterious biochemical effects of mutant TSC1 (show TSC1 ELISA Kits) or TSC2 protein in tuberous sclerosis complex.
Results confirm strong association between TSC2 mutation and angiomyolipoma burden, and they indicate that everolimus response occurs regardless of mutation type or location or when no mutation in TSC1 (show TSC1 ELISA Kits) or TSC2 has been identified.
AKT3 (show AKT3 ELISA Kits) has a role in prostate cancer proliferation through regulation of Akt (show AKT1 ELISA Kits), B-Raf (show SNRPE ELISA Kits), and TSC1 (show TSC1 ELISA Kits)/TSC2
PAK2 (show PAK2 ELISA Kits) is a direct effector of TSC1 (show TSC1 ELISA Kits)-TSC2-RHEB (show RHEB ELISA Kits) signaling and a new target for rational drug therapy in TSC (show SLC12A3 ELISA Kits).
Data show that 10 pathogenic mutations were quickly identified, 7 were located in tuberous sclerosis 1 protein (TSC1 (show TSC1 ELISA Kits)) and 3 were observed in tuberous sclerosis 2 protein (TSC2).
Tuberous sclerosis is a syndrome caused by dominant mutations in Tuberin (TSC2),causing Autism spectrum disorder - like behaviors, seizures, intellectual disability and characteristic brain and skin lesions.
TSC1 (show TSC1 ELISA Kits) and TSC2 mutations are associated with tuberous sclerosis.
Lysosomal recruitment of TSC2 is a universal response to stimuli that inactivate mTORC1, and that the presence of any single stress is sufficient to cause TSC2 lysosomal localization.
TSC (show SLC12A3 ELISA Kits)-related tumors can increase the mutation detection rate, indicate that it is not likely that a third TSC (show SLC12A3 ELISA Kits) gene exists, and enable provision of genetic counseling to the substantial population of TSC (show SLC12A3 ELISA Kits) individuals who are currently NMI (show MYO1C ELISA Kits)
autophagy via the TSC2-mTORC1 signaling pathway plays an important role in maintenance of cardiac function and mitochondrial quantity and size in the heart.
Data indicate that an AMP (show TMPRSS5 ELISA Kits)-ctivated kinase (AMPK (show PRKAA1 ELISA Kits))/cell-cycle inhibitor p27KIP1 (p27 (show CDKN1B ELISA Kits)) axis drives activation of autophagy in rapamycin-treated tuberous sclerosis 2 protein (Tsc2)-null cells.
Axitinib is an effective inhibitor of Tsc2-null lesion growth.
Distinct germline progenitor subsets are defined through Tsc2-mTORC1 signaling.
PLK1 (show PLK1 ELISA Kits) protein levels are increased in hamartin (show TSC1 ELISA Kits) and tuberin deficient cells and Lymphangioleiomyomatosis patient-derived specimens, and that this increase is rapamycin-sensitive.
these results demonstrate that TSC2-deficient cells have enhanced choline phospholipid metabolism and reveal a novel function of the TSC (show SLC12A3 ELISA Kits) proteins in choline lysoglycerophospholipid metabolism
TSC2/mTORC1 signaling contributes to the maintenance of intestinal epithelium homeostasis by regulating Notch (show NOTCH1 ELISA Kits) activity.
This mode of regulation involves TSC (show SLC12A3 ELISA Kits) as knockout of TSC1 (show TSC1 ELISA Kits) or TSC2 rescued TOP mRNAs translation in amino acid-starved cells
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (show PRKAA1 ELISA Kits)/ERK (show MAPK1 ELISA Kits)/TSC2/mTOR (show FRAP1 ELISA Kits) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
prostaglandin F2alpha phosphorylates TSC2 and activates mTOR (show FRAP1 ELISA Kits) and ribosomal protein S6 (show RPS6 ELISA Kits) kinase (show RPS6KB1 ELISA Kits) signaling in an AKT (show AKT1 ELISA Kits)-independent manner
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.
tuberous sclerosis complex 2 (TSC2)
, tuberous sclerosis 2
, tuberous sclerosis 2 protein
, tuberous sclerosis 2 protein homolog
, renal carcinoma
, tuberous sclerosis 2 homolog protein