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Tuberin Products

(Tuberous Sclerosis 2 (TSC2))

Categories

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

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Featured Tuberin Categories

Tuberin Antibodies

High quality antibodies with extensive validation data.

Tuberin ELISA Kits

Reliable ELISA kits for a wide range of species.

Recommended Tuberin Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, IHC (p)
Validations
  • (5)
Cat. No. ABIN390324
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p)
Validations
  • (7)
Cat. No. ABIN3043498
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (1)
  • (3)
Cat. No. ABIN701200
Quantity 100 μL
Datasheet Datasheet

Recommended Tuberin ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970922
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970921
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380275
Quantity 2 x 96 tests
Datasheet Datasheet

Recommended Tuberin Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323848
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our Tuberin products

Wang, Chen, Deng, Bian, Huang, Lei, Lv, Liu, Li: "Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation." in: International journal of biological macromolecules, Vol. 96, pp. 578-588, (2017) (PubMed).

Zhang, Wang, Qin, Wang, Liu, White, Zheng: "PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer." in: EBioMedicine, Vol. 2, Issue 12, pp. 1944-56, (2016) (PubMed).

Wu, Storey: "Regulation of the mTOR signaling network in hibernating thirteen-lined ground squirrels." in: The Journal of experimental biology, Vol. 215, Issue Pt 10, pp. 1720-7, (2012) (PubMed).

Huang, Ratovitski: "Phospho-?Np63?/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells." in: Aging, Vol. 2, Issue 12, pp. 959-68, (2011) (PubMed).

Wang, Chen, Kuo, Su, Lai, Wang, Huang, Hoffman, Kuo, You, Chuang: "Zebrafish Thsd7a is a neural protein required for angiogenic patterning during development." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 240, Issue 6, pp. 1412-21, (2011) (PubMed).

Jham, Ma, Hu, Chaisuparat, Friedman, Pandolfi, Schneider, Sodhi, Montaner: "Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma." in: PLoS ONE, Vol. 6, Issue 4, pp. e19103, (2011) (PubMed).

Dántola, Denofrio, Zurbano, Gimenez, Ogilby, Lorente, Thomas: "Mechanism of photooxidation of folic acid sensitized by unconjugated pterins." in: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, Vol. 9, Issue 12, pp. 1604-12, (2010) (PubMed).

Larson, Liu, Stevens, Li, Li, Evers, Gao: "Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1." in: The Journal of biological chemistry, Vol. 285, Issue 32, pp. 24987-98, (2010) (PubMed).

Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).

Di Nardo, Kramvis, Cho, Sadowski, Meikle, Kwiatkowski, Sahin: "Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 18, pp. 5926-37, (2009) (PubMed).

Synonyms and alternative names related to Tuberin

TSC complex subunit 2 (TSC2), tuberin (LOC5569538), TSC complex subunit 2 (tsc2), hypothetical protein (PGTG_00159), tuberous sclerosis 2 (Tsc2), TSC complex subunit 2 (Tsc2), tuberous sclerosis 2 (TSC2), fc16b02, LAM, Nafld, Rc, Tcs2, TSC2, TSC4, tuberin, wu:fc16b02

Protein level used designations for Tuberin

  • tuberous sclerosis complex 2 (TSC2)
  • tuberous sclerosis 2
  • tuberin-like
  • tuberin
  • tuberous sclerosis 2 protein
  • tuberous sclerosis 2 protein homolog
  • renal carcinoma
  • tuberous sclerosis 2 homolog protein
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