Browse our VEGF Proteins (VEGFA)

Full name:
Vascular Endothelial Growth Factor A Proteins (VEGFA)
On are 131 Vascular Endothelial Growth Factor A (VEGFA) Proteins from 17 different suppliers available. Additionally we are shipping VEGF Antibodies (374) and VEGF Kits (111) and many more products for this protein. A total of 634 VEGF products are currently listed.
eVEGF120, eVEGF164, MVCD1, vefg, Vegf, VEGF-A, Vegf120, VEGF164, Vegf188, vegfa, Vpf, wu:fj82c06
list all proteins Gene Name GeneID UniProt
VEGFA 7422 P15692
VEGFA 22339 Q00731
VEGFA 83785 P16612

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VEGF Proteins (VEGFA) by Origin

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Top referenced VEGF Proteins

  1. Rat (Rattus) VEGF Protein expressed in HEK-293 - ABIN2666575 : Martin, Galisteo, Gutkind et al.: CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) ... in The Journal of biological chemistry 2009 (PubMed)
    Show all 7 references for 2666575

  2. Mouse (Murine) VEGF Protein expressed in HEK-293 - ABIN2666680 : Koch, Claesson-Welsh: Signal transduction by vascular endothelial growth factor receptors. in Cold Spring Harbor perspectives in medicine 2012 (PubMed)
    Show all 6 references for 2666680

  3. Human VEGF Protein expressed in Human Cells - ABIN2003877 : Zachary, Gliki: Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. in Cardiovascular research 2001 (PubMed)
    Show all 2 references for 2003877

  4. Rat (Rattus) VEGF Protein expressed in Baculovirus infected Insect Cells - ABIN2009015 : Robinson, Stringer: The splice variants of vascular endothelial growth factor (VEGF) and their receptors. in Journal of cell science 2001 (PubMed)
    Show all 2 references for 2009015

More Proteins for VEGF Interaction Partners

Zebrafish Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. Tmem2 regulates hyaluronic acid turnover to promote normal Vegf signaling during developmental angiogenesis.

  2. low levels of Vegf signaling promote overall vascular endothelial differentiation and cell survival by upregulating etv2 expression, while high levels of Vegf signaling promote arterial and inhibit venous specification.

  3. altering the amount of VEGF signaling in endothelial cells by stimulating them with different VEGF concentrations triggered distinct and mutually exclusive dynamic Ca(2 (show CA2 Proteins)+) signaling responses that correlated with different cellular behaviors.

  4. Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether downregulate the expression of VEGF and VEGFR, and simultaneously regulates VEGF signaling pathway to prevent angiogenesis.

  5. noncanonical function of tars (show TARS Proteins) regulates vascular development presumably by modulating the expression of vegfa

  6. Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor (show FLT1 Proteins) signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.

  7. The translation initiation factor (show TIF1 Proteins) eIF3i (show EIF3I Proteins) up-regulates VEGF-A, accelerates cell proliferation, and promotes angiogenesis in embryonic development.

  8. lack of SULF1 (show SULF1 Proteins) expression downregulates VEGFA-mediated arterial marker expression, confirming that Sulf1 (show SULF1 Proteins) mediates arterial specification by regulating VegfA165 activity.

  9. yolk-derived 17beta-estradiol sets the ventral boundary of hemogenic vascular niche specification by antagonizing the dorsal-ventral regulatory limits of VEGF.

  10. Vegfaa has a crucial role in angiogenesis and vegfaa expression was upregulated in embryos lacking functional Pten.

Xenopus laevis Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. VEGFA produced in the somites is required to initiate adult haemangioblast programming in the adjacent dorsal lateral plate mesoderm.

  2. sequential, isoform-specific VEGFA signaling successively induces the endothelial, arterial, and hematopoietic stem cell programs in the dorsal aorta.

  3. VEGF induces stromal cell migration or recruitment that are required for blood vessel formation.

  4. increased VEGF(170) levels disturb Hand-1 (show HAND1 Proteins) expression in the region required for normal heart morphogenesis

Cow (Bovine) Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

  2. Studied the effect of cyclic uniaxial stretch (20%, 1 Hz), with and without the stimulation of vascular endothelial growth factor (VEGF), on sprouting angiogenesis by employing a stretchable three-dimensional cell culture model.

  3. Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension.

  4. Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).

  5. Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1 (show XBP1 Proteins)/IRE1 alpha (show ERN1 Proteins) and ATF6 (show ATF6 Proteins) arms of the unfolded protein response compared with untreated cells.

  6. Microvascular endothelial cells are more susceptible than aortic cells to advanced glycation end products-enhanced permeability and that AGE-enhanced permeability is dependent on VEGF expression induced by reactive oxygen species.

  7. VEGF supports germ cell survival and sperm production in bulls.

  8. analysis of polymorphisms of bovine VEGF gene and their associations with growth traits in Chinese cattle

  9. VEGF mRNA expression at estrus was higher than at the early I, early II and late luteal stages (P<0.05), whereas VEGF protein content was greatest at the early I luteal stage and decreased thereafter

  10. Alterations in the expression of VEGF-A and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

Human Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. High VEGF expression was observed in all patients with papillary renal cell carcinoma (show MOK Proteins).

  2. The progression of pregnancy is accompanied by the concerted increase in TNFalpha and VEGF secretion and decrease in the production of their soluble receptors, but the expression of cell surface receptors does not depend on gestational age. The observed patterns of basal and stimulated expression of TNFalpha and VEGF may reflect the dual immune and morphogenetic roles of placental macrophages in gestation.

  3. The frequency of the VEGF-2578capital ES, Cyrilliccapital ES, Cyrillic genotype was increased in Russian women with Rheumatoid arthritis and rheumatoid nodules.

  4. VEGF-A acts via interaction with NRP-1 (show NELL1 Proteins) to trigger intracellular events leading to epidermal cancer stem cells (ECS) cell survival and formation of aggressive, invasive and highly vascularized tumors.

  5. Vascular endothelial growth factor (VEFG)-A, originally described as an angiogenic factor, belongs to a super-family of glycoproteins, and signals through tyrosine kinase (show TXK Proteins) receptors VEGF receptor (show FLT1 Proteins) 1 (VEGFR1 (show FLT1 Proteins)) and VEGF receptor 2 (VEGFR2) and coreceptors, neuropilin (NP) 1 (show NRP1 Proteins) and 2.

  6. Serum BDNF (show BDNF Proteins), VEGF, and IGF-1 (show IGF1 Proteins) levels were significantly higher in the Taekwondo (TKD) training group after the 16-week intervention. The training may have been effective in increasing children's cognitive function by inducing an increase in the levels of neuroplasticity-related growth factors.

  7. Letter: VEGFA and VEGFR2 (show KDR Proteins) SNPs were associated with susceptibility to Paget's disease of bone in Spanish patients.

  8. The data suggested that the +936C/T VEGFA variants significantly increased the risk of poorer stroke outcome by affecting the bindings of miR (show MLXIP Proteins)-199a and miR (show MLXIP Proteins)-199b to VEGFA mRNA at the rs30250340 polymorphic site.

  9. Compared to normal control patients, the serum levels of VEGF were elevated in stable asthma patients and even more elevated in patients with acute exacerbation. However, the role of VEGF as a biomarker in stable asthma is limited. In patients with acute exacerbation, VEGF levels were associated with clinical improvements.

  10. These five SNPs in the KRAS gene and the VEGF gene were not associated with CRC (show CALR Proteins) susceptibility.

Mouse (Murine) Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. Vascular endothelial growth factor (VEFG)-A, originally described as an angiogenic factor, belongs to a super-family of glycoproteins, and signals through tyrosine kinase (show TYRO3 Proteins) receptors VEGF receptor (show FLT1 Proteins) 1 (VEGFR1 (show FLT1 Proteins)) and VEGF receptor 2 (VEGFR2) and coreceptors, neuropilin (NP) 1 (show NRP1 Proteins) and 2.

  2. VEGF-A overexpression in adipocytes triggers angiogenesis. There was a rapid appearance of beige fat cells in subcutaneous white adipose tissue as early as 2 days postinduction of VEGF-A. In contrast to conventional cold-induced beiging, VEGF-A-induced beiging is independent of interleukin-4 (show IL4 Proteins).

  3. Data show that Leishmania major infection initiates enhanced vascular endothelial growth factor-A/VEGFR-2 (show KDR Proteins) signaling and suggest that VEGFR-2 (show KDR Proteins)-dependent lymphangiogenesis is a mechanism that restricts tissue inflammation in leishmaniasis.

  4. VEGFR3 (show FLT4 Proteins) limits VEGFR2 (show KDR Proteins) expression and VEGF/VEGFR2 (show KDR Proteins) pathway activity in quiescent and angiogenic blood vascular endothelial cells, thereby preventing excessive vascular permeability.

  5. VEGF165-induced vascular leakage requires both VEGFR2 (show KDR Proteins) and NRP1 (show NRP1 Proteins), including the VEGF164-binding site of NRP1 (show NRP1 Proteins) and the NRP1 (show NRP1 Proteins) cytoplasmic domain (NCD), but not the known NCD interactor GIPC1 (show GIPC1 Proteins).

  6. Apelin could effectively promote mesenchymal stem cell survival and vascularization under hypoxic-ischemic condition in vitro, and this procedure was associated with the upregulation of VEGF.

  7. BLT2 expression in mast cells is essential for the production of VEGF in OVA-induced allergic asthma.

  8. Stability and species specificity of renal VEGF-A splicing patterns in kidney disease in humans and mice has been demonstrated.

  9. Novel VF-Trap fusion protein on blockage of VEGF and FGF-2 (show FGF2 Proteins) activity to prevent angiogenesis.

  10. E2F1 (show E2F1 Proteins) hinders skin wound healing by suppressing VEGF expression, neovascularization, and macrophage recruitment. Strategies that target E2F1 (show E2F1 Proteins) may enhance wound healing.

Pig (Porcine) Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. It was concluded that VEGF and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.

  2. results are consistent with a participation of (VEFG) in the regulation of the dynamics of oviductal fluid secretion and the oviduct contractibility

  3. Here we demonstrate that VEGF-165 mediates MSC (show MSC Proteins) differentiation into ECs via VEGFR-2 (show KDR Proteins)-dependent induction of Sox18 (show SOX18 Proteins), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype.

  4. VEGF was significantly downregulated 7 days after cryotherapy of the sclera and stayed at that level until day 14. It returned to baseline by day 21.

  5. VEGF production, blood vessel network and follicle remodeling are impaired by the antiprogesterone RU486.

  6. findings suggest that the augmented neovascular response seen with VEGF administration was through the VEGF-induced upregulation of Notch (show NOTCH1 Proteins) signaling.

  7. interleukin-1beta-induced vascular endothelial growth factor in airway smooth muscle cells

  8. Upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1alpha (show HIF1A Proteins).

  9. data shows that members of the VEGF-VEGFR (show KDR Proteins) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy

  10. cardiac-specific and hypoxia-induced coexpression of VEGF and Ang1 (show ANGPT1 Proteins) improves the perfusion and function of porcine MI heart through the induction of angiogenesis and cardiomyocyte proliferation

Horse (Equine) Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion

  2. TNF (show TNF Proteins) may up-regulate VEGF and stimulate angiogenesis in the mare (show C16orf35 Proteins) early corpus luteum.

Guinea Pig Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. After acoustic trauma, vascular endothelial growth factor was up-regulated both in the cochlea and vestibule. Expression in both structures suggests a reparative role with potentially therapeutic implications.

  2. Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.

Rabbit Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but the level increased at 144 h in uterus.

  2. correlation was observed between CT perfusion parameters (BF, BV, PS, and MAV (show KLHL2 Proteins)) and expression of VEGF and MVD (show MVD Proteins) in tumor tissue

  3. Physiologic ischemic training stimulates VEGF-mediated mobilization of endothelial progenitor cells as well as angiogenesis.

  4. Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.

  5. Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 (show MMP9 Proteins) in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.

  6. VEGF expression peaked at 8 weeks after meniscus transplantation

  7. Studied the biocompatibility and neovascularization of the PLGA nanospheres wrapped with vascular endothelial growth factor (VEGF).

  8. VEGF induces TGF-beta1 (show TGFB1 Proteins) expression and myofibroblast transformation after glaucoma surgery.

  9. The results of this study are promising concerning the role of VEGF as a diagnostic marker in moderate osteoarthritis

  10. The overexpression of VEGF increased tumor growth and vascularization, favored cyst formation, and reduced tumor necrosis.

Rhesus Monkey Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. VEGF plays an important role in choroid-retinal endothelial cell proliferation and tube formation.

  2. These findings suggest that FBLN5 (show FBLN5 Proteins) may interfere with choroidal neovascularization by downregulating VEGF, CXCR4 (show CXCR4 Proteins), and TGFB1 (show TGFB1 Proteins) expression and inhibiting choroidl endothelial cell proliferation.

  3. Apelin may play a role in the development of central retinal vein occlusion (CRVO). Apelin has a unique upstream signaling pathway, independent of the VEGF pathway.

  4. Dll4 play an important role in choroidal neovascularization (CNV) angiogenesis, which appears to be regulated by HIF-1alpha and VEGF during the progression of CNV under hypoxic conditions.

  5. A functional network involving VEGF, IGF2, and MMP9 (show MMP9 Proteins) in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.

VEGF (VEGFA) Protein Profile

Protein Summary

This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

Alternative names and synonyms associated with VEGF (VEGFA)

  • vascular endothelial growth factor Aa (vegfaa)
  • vascular endothelial growth factor A (vegfa-a)
  • vascular endothelial growth factor A (VEGFA)
  • vascular endothelial growth factor A (vegfa)
  • vascular endothelial growth factor A (Vegfa)
  • eVEGF120 protein
  • eVEGF164 protein
  • MVCD1 protein
  • vefg protein
  • Vegf protein
  • VEGF-A protein
  • Vegf120 protein
  • VEGF164 protein
  • Vegf188 protein
  • vegfa protein
  • Vpf protein
  • wu:fj82c06 protein

Protein level used designations for VEGFA

VEGF-A-A , etID309976.16 , vascular endothelial growth factor A , vascular endothelial growth factor A-A , vegf-a , vascular endothelial growth factor A-a , vascular endothelial growth factor 164 , vascular permeability factor , VEGF-A , VPF , vascular endothelial growth factor 188 , angiogenic factor , Vascular permeability factor , endothelial growth factor-164 , vascular endothelial growth factor VEGF

30682 Danio rerio
373589 Xenopus laevis
493845 Felis catus
100038089 Xenopus (Silurana) tropicalis
281572 Bos taurus
7422 Homo sapiens
22339 Mus musculus
83785 Rattus norvegicus
397157 Sus scrofa
403802 Canis lupus familiaris
395909 Gallus gallus
100033839 Equus caballus
443103 Ovis aries
100713483 Cavia porcellus
100860957 Capra hircus
100008899 Oryctolagus cuniculus
101839822 Mesocricetus auratus
574209 Macaca mulatta
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