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Browse our VEGF Proteins (VEGFA)

Full name:
Vascular Endothelial Growth Factor A Proteins (VEGFA)
On are 120 Vascular Endothelial Growth Factor A (VEGFA) Proteins from 15 different suppliers available. Additionally we are shipping VEGF Antibodies (368) and VEGF Kits (96) and many more products for this protein. A total of 599 VEGF products are currently listed.
eVEGF120, eVEGF164, MVCD1, vefg, Vegf, VEGF-A, Vegf120, VEGF164, Vegf188, vegfa, Vpf, wu:fj82c06
list all proteins Gene Name GeneID UniProt
VEGFA 7422 P15692
VEGFA 22339 Q00731
VEGFA 83785 P16612

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VEGF Proteins (VEGFA) by Origin

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Top referenced VEGF Proteins

  1. Rat (Rattus) VEGF Protein expressed in HEK-293 - ABIN2666575 : Martin, Galisteo, Gutkind et al.: CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) ... in The Journal of biological chemistry 2009 (PubMed)
    Show all 7 references for ABIN2666575

  2. Mouse (Murine) VEGF Protein expressed in HEK-293 - ABIN2666680 : Koch, Claesson-Welsh: Signal transduction by vascular endothelial growth factor receptors. in Cold Spring Harbor perspectives in medicine 2012 (PubMed)
    Show all 6 references for ABIN2666680

  3. Human VEGF Protein expressed in Human Cells - ABIN2001884 : Zachary, Gliki: Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. in Cardiovascular research 2001 (PubMed)
    Show all 2 references for ABIN2001884

  4. Mouse (Murine) VEGF Protein expressed in Baculovirus infected Insect Cells - ABIN2007420 : Robinson, Stringer: The splice variants of vascular endothelial growth factor (VEGF) and their receptors. in Journal of cell science 2001 (PubMed)
    Show all 2 references for ABIN2007420

More Proteins for VEGF Interaction Partners

Zebrafish Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. noncanonical function of tars (show TARS Proteins) regulates vascular development presumably by modulating the expression of vegfa

  2. Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor (show FLT1 Proteins) signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.

  3. The translation initiation factor (show TIF1 Proteins) eIF3i (show EIF3I Proteins) up-regulates VEGF-A, accelerates cell proliferation, and promotes angiogenesis in embryonic development.

  4. lack of SULF1 (show SULF1 Proteins) expression downregulates VEGFA-mediated arterial marker expression, confirming that Sulf1 (show SULF1 Proteins) mediates arterial specification by regulating VegfA165 activity.

  5. yolk-derived 17beta-estradiol sets the ventral boundary of hemogenic vascular niche specification by antagonizing the dorsal-ventral regulatory limits of VEGF.

  6. Vegfaa has a crucial role in angiogenesis and vegfaa expression was upregulated in embryos lacking functional Pten.

  7. Over expression of zebrafish vegf-a rescues Methyl tert (show TERT Proteins)-butyl ether induced vascular lesions.

  8. Elevated Notch (show NOTCH1 Proteins) signaling downstream of perturbed VEGF signaling contributes to aberrant flt-1 (show FLT1 Proteins)(-/-) blood vessel formation.

  9. At the molecular level, we show that the circadian regulator Bmal1 directly targets the promoter region of the vegf gene in zebrafish, leading to an elevated expression of VEGF.

  10. Opposing effects of circadian clock genes bmal1 and period2 in regulation of VEGF-dependent angiogenesis in developing zebrafish.

Xenopus laevis Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. VEGFA produced in the somites is required to initiate adult haemangioblast programming in the adjacent dorsal lateral plate mesoderm.

  2. sequential, isoform-specific VEGFA signaling successively induces the endothelial, arterial, and hematopoietic stem cell programs in the dorsal aorta.

  3. VEGF induces stromal cell migration or recruitment that are required for blood vessel formation.

  4. increased VEGF(170) levels disturb Hand-1 (show HAND1 Proteins) expression in the region required for normal heart morphogenesis

Cow (Bovine) Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. Studied the effect of cyclic uniaxial stretch (20%, 1 Hz), with and without the stimulation of vascular endothelial growth factor (VEGF), on sprouting angiogenesis by employing a stretchable three-dimensional cell culture model.

  2. Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension.

  3. Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).

  4. Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1 (show XBP1 Proteins)/IRE1 alpha (show ERN1 Proteins) and ATF6 (show ATF6 Proteins) arms of the unfolded protein response compared with untreated cells.

  5. Microvascular endothelial cells are more susceptible than aortic cells to advanced glycation end products-enhanced permeability and that AGE-enhanced permeability is dependent on VEGF expression induced by reactive oxygen species.

  6. VEGF supports germ cell survival and sperm production in bulls.

  7. analysis of polymorphisms of bovine VEGF gene and their associations with growth traits in Chinese cattle

  8. VEGF mRNA expression at estrus was higher than at the early I, early II and late luteal stages (P<0.05), whereas VEGF protein content was greatest at the early I luteal stage and decreased thereafter

  9. Alterations in the expression of VEGF-A and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

  10. Advanced glycation end products increase, through a protein kinase C-dependent pathway, expression in reignal endothelial cells; inhibited by gliclazide.

Human Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. VEGF mediates shock wave-induced endothelial cell proliferation in a cell-autonomous manner.

  2. VEGF and MMP-9 (show MMP9 Proteins) are overexpressed in lung adenocarcinoma tissues, and they have a synergistic effect on the invasion and metastasis of adenocarcinoma.

  3. TMP upregulated the expression of prolyl hydroxylase (PHD)2, reduced the protein and mRNA expression levels of vascular endothelial growth factor (VEGF), and reduced the expression of HIF-1alpha only at the protein level, not at the mRNA level in HUVECs, in a concentration-dependent manner

  4. Serum concentrations of HIF-1alpha (t=25.53, P<0.05) and VEGF (t=12.10, P<0.05) in early stage group were significantly higher than those in normal group.

  5. High VEGF expression was subsequently correlated with a short overall survival rate for patients exhibiting lymph node metastasis (P=0.0128); however, there was no significant difference in overall survival rate regarding the expression levels of TP and CD34 (show CD34 Proteins)

  6. The results indicated that vascular endothelial growth factor A (VEGFA) was a direct target of miR (show MLXIP Proteins)-206 in renal cancer cells. Further studies revealed that upregulation of miR (show MLXIP Proteins)-206 inhibited renal cancer cell proliferation, invasion and migration

  7. miR (show MLXIP Proteins)-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model, which was probably caused by the downregulation of pro-angiogenic molecules, such as VEGF and HIF-1alpha (show HIF1A Proteins).

  8. Our findings suggest a strong association between the VEGFA and VEGFR2 (show KDR Proteins) polymorphisms and adverse clinico-pathological parameters in chronic myeloid leukemia (show BCL11A Proteins), also found significant genotype interactions in VEGFA and VEGFR2 (show KDR Proteins) genes in elevated risk for chronic myeloid leukemia (show BCL11A Proteins) susceptibility.

  9. Suggest that miR (show MLXIP Proteins)-195, a tumor suppressor miRNA, contributes to the lung metastasis of HCC (show FAM126A Proteins) by negatively regulating FGF2 (show FGF2 Proteins) and VEGFA expression.

  10. Genetic interactions of SNPs in CARD14 (show CARD14 Proteins), SENP1 (show SENP1 Proteins) and VEGFA might represent a functional mechanism in the pathogenesis of high altitude polycythemia.

Mouse (Murine) Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. results suggest that sustained intraocular VEGF neutralization induces retinal neurodegeneration and vascular damage in the diabetic eye.

  2. VEGF-dependent capillary maintenance supports muscle growth.

  3. Data suggest that expression of Notch-1 (show NOTCH1 Proteins) receptor in endothelial progenitor cells (EPC (show TCF21 Proteins)) in bone marrow is up-regulated in diabetic angiopathy (DA); signaling in EPC (show TCF21 Proteins) via Notch-1 (show NOTCH1 Proteins) receptor and VEGFA/VEGFR2 (show KDR Proteins) appears to be altered in DA.

  4. Both placental NRP1 and VEGF were expressed at lower levels in women with pre-eclampsia and homocysteine-treated mice, which may contribute to endothelial damage.

  5. Collectively, these data suggest that VEGF/VEGFR2 (show KDR Proteins) signaling regulates germ cell proliferation and promotes testicular regeneration via direct action on germ cells and the enhancement of vascularization.

  6. Time-dependent changes in endometrial hypoxia during menstruation correlated with the regulation of mRNAs encoding for the angiogenic genes Vegfa and Cxcl12 (show CXCL12 Proteins).

  7. RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix.

  8. Low alpha-KG levels promotes stabilization of hypoxia-induced factor 1a (Hif1a (show HIF1A Proteins)) and secretion of vascular endothelial growth factor A (Vegfa) by starved Vldlr (show VLDLR Proteins)(-/-) photoreceptors

  9. A2B adenosine receptor-induced VEGF production and angiogenesis are involved in myeloid-derived suppressor cells in a mouse melanoma model

  10. Our results encourage further therapeutic studies, particularly if one considers that the anti-Id therapeutic vaccination maintains stable levels of VEGF-binding antibodies, which might be useful in the control of tumor relapse.

Pig (Porcine) Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. Here we demonstrate that VEGF-165 mediates MSC (show MSC Proteins) differentiation into ECs via VEGFR-2 (show KDR Proteins)-dependent induction of Sox18 (show SOX18 Proteins), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype.

  2. VEGF was significantly downregulated 7 days after cryotherapy of the sclera and stayed at that level until day 14. It returned to baseline by day 21.

  3. VEGF production, blood vessel network and follicle remodeling are impaired by the antiprogesterone RU486.

  4. findings suggest that the augmented neovascular response seen with VEGF administration was through the VEGF-induced upregulation of Notch (show NOTCH1 Proteins) signaling.

  5. interleukin-1beta-induced vascular endothelial growth factor in airway smooth muscle cells

  6. Upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1alpha (show HIF1A Proteins).

  7. data shows that members of the VEGF-VEGFR (show KDR Proteins) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy

  8. cardiac-specific and hypoxia-induced coexpression of VEGF and Ang1 (show ANGPT1 Proteins) improves the perfusion and function of porcine MI heart through the induction of angiogenesis and cardiomyocyte proliferation

  9. The mRNA for VEGFA was expressed in early developing and in maturing glomeruli.

  10. Data show that subventricular zone neural stem cells express VEGF and all VEGF splice variants, VEGFR1 (show FLT1 Proteins), VEGFR2 (show KDR Proteins) and Neuropilin-1 (show NRP1 Proteins) and -2 mRNAs.

Horse (Equine) Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion

  2. TNF (show TNF Proteins) may up-regulate VEGF and stimulate angiogenesis in the mare (show C16orf35 Proteins) early corpus luteum.

Rabbit Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but the level increased at 144 h in uterus.

  2. correlation was observed between CT perfusion parameters (BF, BV, PS, and MAV (show KLHL2 Proteins)) and expression of VEGF and MVD (show MVD Proteins) in tumor tissue

  3. Physiologic ischemic training stimulates VEGF-mediated mobilization of endothelial progenitor cells as well as angiogenesis.

  4. Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.

  5. Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 (show MMP9 Proteins) in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.

  6. VEGF expression peaked at 8 weeks after meniscus transplantation

  7. Studied the biocompatibility and neovascularization of the PLGA nanospheres wrapped with vascular endothelial growth factor (VEGF).

  8. VEGF induces TGF-beta1 (show TGFB1 Proteins) expression and myofibroblast transformation after glaucoma surgery.

  9. The results of this study are promising concerning the role of VEGF as a diagnostic marker in moderate osteoarthritis

  10. The overexpression of VEGF increased tumor growth and vascularization, favored cyst formation, and reduced tumor necrosis.

Rhesus Monkey Vascular Endothelial Growth Factor A (VEGFA) interaction partners

  1. VEGF plays an important role in choroid-retinal endothelial cell proliferation and tube formation.

  2. These findings suggest that FBLN5 (show FBLN5 Proteins) may interfere with choroidal neovascularization by downregulating VEGF, CXCR4 (show CXCR4 Proteins), and TGFB1 (show TGFB1 Proteins) expression and inhibiting choroidl endothelial cell proliferation.

  3. Apelin may play a role in the development of central retinal vein occlusion (CRVO). Apelin has a unique upstream signaling pathway, independent of the VEGF pathway.

  4. Dll4 play an important role in choroidal neovascularization (CNV) angiogenesis, which appears to be regulated by HIF-1alpha and VEGF during the progression of CNV under hypoxic conditions.

  5. A functional network involving VEGF, IGF2, and MMP9 (show MMP9 Proteins) in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.

VEGF (VEGFA) Protein Profile

Protein Summary

This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

Alternative names and synonyms associated with VEGF (VEGFA)

  • vascular endothelial growth factor Aa (vegfaa)
  • vascular endothelial growth factor A (vegfa-a)
  • vascular endothelial growth factor A (VEGFA)
  • vascular endothelial growth factor A (vegfa)
  • vascular endothelial growth factor A (Vegfa)
  • eVEGF120 protein
  • eVEGF164 protein
  • MVCD1 protein
  • vefg protein
  • Vegf protein
  • VEGF-A protein
  • Vegf120 protein
  • VEGF164 protein
  • Vegf188 protein
  • vegfa protein
  • Vpf protein
  • wu:fj82c06 protein

Protein level used designations for VEGFA

VEGF-A-A , etID309976.16 , vascular endothelial growth factor A , vascular endothelial growth factor A-A , vegf-a , vascular endothelial growth factor A-a , vascular endothelial growth factor 164 , vascular permeability factor , VEGF-A , VPF , vascular endothelial growth factor 188 , angiogenic factor , Vascular permeability factor , endothelial growth factor-164 , vascular endothelial growth factor VEGF

30682 Danio rerio
373589 Xenopus laevis
493845 Felis catus
100038089 Xenopus (Silurana) tropicalis
281572 Bos taurus
7422 Homo sapiens
22339 Mus musculus
83785 Rattus norvegicus
397157 Sus scrofa
403802 Canis lupus familiaris
395909 Gallus gallus
100033839 Equus caballus
443103 Ovis aries
100713483 Cavia porcellus
100860957 Capra hircus
100008899 Oryctolagus cuniculus
101839822 Mesocricetus auratus
574209 Macaca mulatta
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