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This study demonstrates the involvement of VEGF signaling in regulating sustained liver injuries after acute alcohol exposure.
we determined that radial glia control this process via the Vegf decoy receptor sFlt1 (show FLT1 Proteins): sflt1 (show FLT1 Proteins) mutants exhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 (show FLT1 Proteins) overexpression rescues it. Genetic mosaic analyses show that sFlt1 (show FLT1 Proteins) function in trunk endothelial cells can limit their over-sprouting.
High VEGFA expression is associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors.
Rspo1 (show RSPO1 Proteins) is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC (show FUT1 Proteins) specification: Wnt16 (show WNT16 Proteins)/DeltaC/DeltaD and Vegfa/Tgfbeta1 (show TGFB1 Proteins)
Tmem2 regulates hyaluronic acid turnover to promote normal Vegf signaling during developmental angiogenesis.
low levels of Vegf signaling promote overall vascular endothelial differentiation and cell survival by upregulating etv2 expression, while high levels of Vegf signaling promote arterial and inhibit venous specification.
altering the amount of VEGF signaling in endothelial cells by stimulating them with different VEGF concentrations triggered distinct and mutually exclusive dynamic Ca(2 (show CA2 Proteins)+) signaling responses that correlated with different cellular behaviors.
Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether downregulate the expression of VEGF and VEGFR, and simultaneously regulates VEGF signaling pathway to prevent angiogenesis.
noncanonical function of tars (show TARS Proteins) regulates vascular development presumably by modulating the expression of vegfa
Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor (show FLT1 Proteins) signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.
VEGFA produced in the somites is required to initiate adult haemangioblast programming in the adjacent dorsal lateral plate mesoderm.
sequential, isoform-specific VEGFA signaling successively induces the endothelial, arterial, and hematopoietic stem cell programs in the dorsal aorta.
VEGF induces stromal cell migration or recruitment that are required for blood vessel formation.
increased VEGF(170) levels disturb Hand-1 (show HAND1 Proteins) expression in the region required for normal heart morphogenesis
data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.
Studied the effect of cyclic uniaxial stretch (20%, 1 Hz), with and without the stimulation of vascular endothelial growth factor (VEGF), on sprouting angiogenesis by employing a stretchable three-dimensional cell culture model.
Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension.
Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).
Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1 (show XBP1 Proteins)/IRE1 alpha (show ERN1 Proteins) and ATF6 (show ATF6 Proteins) arms of the unfolded protein response compared with untreated cells.
Microvascular endothelial cells are more susceptible than aortic cells to advanced glycation end products-enhanced permeability and that AGE-enhanced permeability is dependent on VEGF expression induced by reactive oxygen species.
VEGF supports germ cell survival and sperm production in bulls.
analysis of polymorphisms of bovine VEGF gene and their associations with growth traits in Chinese cattle
VEGF mRNA expression at estrus was higher than at the early I, early II and late luteal stages (P<0.05), whereas VEGF protein content was greatest at the early I luteal stage and decreased thereafter
Alterations in the expression of VEGF-A and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
This study shows that AITD are influenced by 3 SNPs linked to VEGF circulating levels. Whereas rs10738760 appeared specific to GD and FT3 production after six months of treatment, rs6921438 and rs4416670 were implicated in the risk for GD. This study opens new ways to test pharmacogenomics concepts in the future especially in GD in which recurrence prognosis is still challenging.
aracatinib did not increase the efficacy of a VEGF-targeted therapy (cediranib) in this setting. Biomarker analysis did not identify consistent predictive biomarkers.
The results showed a significantly higher expression of VEGF in patients with adenomyosis pain phenotype compared to the same in women with silent form in the epithelial cells of ectopic endometrium (14,7 +/- 1,6 vs. 10,7 +/- 1,6%, p<0,01) in the smooth muscle cells of the myometrium (12,6 +/- 1,4 vs. 9,6 +/- 1,2%, p<0,01), in the stromal cells of the myometrium (10,1 +/- 1,9 vs. 7,4 +/- 1,8%, p <0,01).
In ARPE-19 cells, a human retinal pigment epithelial cell line, MDA treatment induced vascular endothelial growth factor (VEGF) expression alternation, cell junction disruption, and autophagy dysfunction that was also observed in eyes of AMD patients
Results show that VEGF is overexpressed in colorectal tumors and is involved in GAP2 promoting tumor growth and angiogenesis through its upregulation mediated by the MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins)/c-Myc (show MYC Proteins) pathway.
this descriptive study highlights the specificity of VEGF mRNA isoforms in AITD, a fact underlining the need for novel clinical trials and the development of personalised theranostic approaches.
Data show that tumor vessel density was increased by enhanced expression levels of VEGF and FGF.
AAV-CRISRP/Cas9-mediated depletion of VEGFR2 (show KDR Proteins) is a potential therapeutic strategy for pathologic angiogenesis.
increased CRMP4 expression mediated by the activation of VEGF signaling facilitates gastric tumor growth and metastasis, which may have clinical implications associated with a reduced survival rate in gastric cancer patients
Lower VEGF levels are associated with the presence of symptomatic intracranial atherosclerotic stenosis. The severity of ICAS is positively correlated with the levels of VEGF.
Results provide evidence that VEGF derived from Osx+ osteoblast progenitor cells is required for optimal ossification of developing mandibular bones and modulates mechanisms controlling BMP-dependent specification and expansion of the jaw mesenchyme.
The MDA-induced VEGF increase was inhibited by autophagy-lysosomal inhibitors. Intravitreal MDA injection in mice increased laser-induced choroidal neovascularization (laser-CNV) volumes. In a mouse model fed a high-linoleic acid diet for 3 months, we found a significant increase in MDA levels, autophagic activity, and laser-CNV volumes
deletion of AT2 receptor reduced SHP-1 activity and restored VEGF actions, leading to an increased blood flow reperfusion after ischemia in diabetes mellitus.
ata indicate that the HIF-1alpha (show HIF1A Proteins)/VEGF-A axis is an essential aspect of tumor immunity.
It has been concluded that stimulation of VEGF release is a key factor in the promotion of macrophage proliferation by ceramide 1-phosphate.
8-Br-cAMP-induced cell-secreted VEGF is biologically active and may promote angiogenesis
results suggested that the combination of nCS (to support bone formation) with a fibrin-based VEGF/FGF9 release system (support vascular formation) is an innovative and effective strategy that significantly enhanced ectopic bone formation in vivo.
Astrocyte-derived vascular endothelial growth factor-A (VEGF-A) is known to induce BBB dysfunction.(review)
CRP (show CRP Proteins) can upregulate vascular endothelial growth factor-A (VEGF-A) expression by activating hypoxia inducible factor-1alpha (HIF-1alpha (show HIF1A Proteins)) in ADSCs.
VEGF and IGF1 (show IGF1 Proteins) were critical factors for the spontaneous cardiac differentiation of BATDCs, and MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) signaling was involved in the role of VEGF and IGF1 (show IGF1 Proteins).
It was concluded that VEGF and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.
results are consistent with a participation of (VEFG) in the regulation of the dynamics of oviductal fluid secretion and the oviduct contractibility
Here we demonstrate that VEGF-165 mediates MSC (show MSC Proteins) differentiation into ECs via VEGFR-2 (show KDR Proteins)-dependent induction of Sox18 (show SOX18 Proteins), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype.
VEGF was significantly downregulated 7 days after cryotherapy of the sclera and stayed at that level until day 14. It returned to baseline by day 21.
VEGF production, blood vessel network and follicle remodeling are impaired by the antiprogesterone RU486.
findings suggest that the augmented neovascular response seen with VEGF administration was through the VEGF-induced upregulation of Notch (show NOTCH1 Proteins) signaling.
interleukin-1beta-induced vascular endothelial growth factor in airway smooth muscle cells
Upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1alpha (show HIF1A Proteins).
data shows that members of the VEGF-VEGFR (show KDR Proteins) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy
cardiac-specific and hypoxia-induced coexpression of VEGF and Ang1 (show ANGPT1 Proteins) improves the perfusion and function of porcine MI heart through the induction of angiogenesis and cardiomyocyte proliferation
Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion
TNF (show TNF Proteins) may up-regulate VEGF and stimulate angiogenesis in the mare (show C16orf35 Proteins) early corpus luteum.
After acoustic trauma, vascular endothelial growth factor was up-regulated both in the cochlea and vestibule. Expression in both structures suggests a reparative role with potentially therapeutic implications.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
ghrelin (show GHRL Proteins) can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF and VEGFR2 (show KDR Proteins) expression, inhibiting the plaque content of macrophages, and reducing MCP-1 (show CCL2 Proteins) expression at an advanced stage of atherosclerosis in rabbits
VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but the level increased at 144 h in uterus.
correlation was observed between CT perfusion parameters (BF, BV, PS, and MAV (show KLHL2 Proteins)) and expression of VEGF and MVD (show MVD Proteins) in tumor tissue
Physiologic ischemic training stimulates VEGF-mediated mobilization of endothelial progenitor cells as well as angiogenesis.
Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.
Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 (show MMP9 Proteins) in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.
VEGF expression peaked at 8 weeks after meniscus transplantation
Studied the biocompatibility and neovascularization of the PLGA nanospheres wrapped with vascular endothelial growth factor (VEGF).
VEGF induces TGF-beta1 (show TGFB1 Proteins) expression and myofibroblast transformation after glaucoma surgery.
The results of this study are promising concerning the role of VEGF as a diagnostic marker in moderate osteoarthritis
VEGF plays an important role in choroid-retinal endothelial cell proliferation and tube formation.
These findings suggest that FBLN5 (show FBLN5 Proteins) may interfere with choroidal neovascularization by downregulating VEGF, CXCR4 (show CXCR4 Proteins), and TGFB1 (show TGFB1 Proteins) expression and inhibiting choroidl endothelial cell proliferation.
Apelin may play a role in the development of central retinal vein occlusion (CRVO). Apelin has a unique upstream signaling pathway, independent of the VEGF pathway.
Dll4 play an important role in choroidal neovascularization (CNV) angiogenesis, which appears to be regulated by HIF-1alpha and VEGF during the progression of CNV under hypoxic conditions.
A functional network involving VEGF, IGF2, and MMP9 (show MMP9 Proteins) in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.
, vascular endothelial growth factor A
, vascular endothelial growth factor A-A
, vascular endothelial growth factor A-a
, vascular endothelial growth factor 164
, vascular permeability factor
, vascular endothelial growth factor 188
, angiogenic factor
, Vascular permeability factor
, endothelial growth factor-164
, vascular endothelial growth factor VEGF