Browse our EYA1 Proteins (EYA1)

Full name:
Eyes Absent Homolog 1 (Drosophila) Proteins (EYA1)
On www.antibodies-online.com are 3 Eyes Absent Homolog 1 (Drosophila) (EYA1) Proteins from 2 different suppliers available. Additionally we are shipping EYA1 Antibodies (64) and many more products for this protein. A total of 76 EYA1 products are currently listed.
Synonyms:
BOP, BOR, BOS1, EYA1, wu:fc13c10, XEya1, zgc:100770
list all proteins Gene Name GeneID UniProt
EYA1 14048  
EYA1 2138 Q99502
Rat EYA1 EYA1 502935  

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EYA1 Proteins (EYA1) by Origin

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More Proteins for EYA1 Interaction Partners

Mouse (Murine) Eyes Absent Homolog 1 (Drosophila) (EYA1) interaction partners

  1. Eya1 phosphatase promotes Shh (show SHH Proteins) signaling during hindbrain development and oncogenesis

  2. results reveal a functional link between Eya1, Six2 (show SIX2 Proteins), and Myc (show MYC Proteins) in driving the expansion and maintenance of the multipotent progenitors during nephrogenesis

  3. BOR syndrome-associated Eya1 missense mutations S454P, L472R, and L550P lead to enhanced proteasomal degradation of the Eya1 protein.

  4. these findings reveal that the canonical Wnt (show WNT2 Proteins) and PI3K/Akt (show AKT1 Proteins) signal pathways restrain the GSK3/Fbw7 (show FBXW7 Proteins)-dependent Eya1 ubiquitination, and they further suggest that dysregulation of this novel axis contributes to tumorigenesis.

  5. The EYA1 phosphatase regulates cell-cycle control via transcriptional complex formation at the cyclin D1 (show CCND1 Proteins) promoter.

  6. These findings uncover novel functions for Six1 (show SIX1 Proteins)-Eya1-SHH (show SHH Proteins) pathway during the saccular phase of lung morphogenesis.

  7. Eya1 is crucial for the maintenance of tight junction protein (show OCLN Proteins) assembly in the lung epithelium.

  8. EYA1 is efficiently degraded during mitotic exit in a ANAPC1-dependent manner and these two proteins physically interact.

  9. EYA1 and SIX1 (show SIX1 Proteins) drive the neuronal developmental program in cooperation with the SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) chromatin-remodeling complex and SOX2 (show SOX2 Proteins) in the mammalian inner ear.

  10. Deletion of either or both Six1 (show SIX1 Proteins) and Eya1 genes results in genitourinary tract defects including persistent cloaca; hypospadias; and hypoplastic genitalia.

Zebrafish Eyes Absent Homolog 1 (Drosophila) (EYA1) interaction partners

  1. Data report the identification of the related proteins Sipl1 (Shank-interacting protein-like 1) and Rbck1 (RBCC protein interacting with PKC1 (show RBCK1 Proteins)) as novel interaction partners of Eya1.

  2. First report of an essential role of Eya1, which is required for lineage-specific differentiation of adenohypophyseal cells, but not for their survival.

Xenopus laevis Eyes Absent Homolog 1 (Drosophila) (EYA1) interaction partners

  1. These studies lend support to the hypothesis that dominant-negative effects of EYA1 mutations may have a role in the pathogenesis of branchio-oto (show PGAP1 Proteins)-renal syndrome.

  2. Eya1 and Six1 (show SIX1 Proteins) are required for both the regulation of placodal neuronal progenitor proliferation, through their effects on SoxB1 expression, and subsequent neuronal differentiation.

Human Eyes Absent Homolog 1 (Drosophila) (EYA1) interaction partners

  1. A variety of DNA changes including large deletions underlie BOR syndrome in different populations, which can be detected with comprehensive genetic testing

  2. Results found that EYA1 affects FBW7 (show FBXW7 Proteins)-Myc (show MYC Proteins) binding to regulate the FBW7 (show FBXW7 Proteins)-mediated Myc (show MYC Proteins) degradation machinery in breast cancer cells.

  3. miR (show MLXIP Proteins)-101 is downregulated in breast cancer, and can inhibit cell proliferation and promote apoptosis by targeting EYA1 through the Notch (show NOTCH1 Proteins) signaling pathway.

  4. Association between EYA1 three SNPs and NSOCs and suggested that maternal environmental tobacco smoke, common cold history, and alcohol consumption.

  5. Our findings implicate this EYA1 partial duplication segregating with branchiootic phenotype in a Brazilian pedigree and is the first description of a large duplication leading to the Branchiootorenal syndrome/BO syndrom

  6. Three causative genes for BOR syndrome have been reported thus far: EYA1, SIX1 (show SIX1 Proteins), and SIX5, but the causative genes for approximately half of all BOR patients remain unknown.[review]

  7. we proved that the branchiooto (BO) syndrome in these cases was caused by germinal mosaicism of the EYA1 gene in either the mother or father.

  8. PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling enhances Eya1 transcription activity, which largely attributes to the phosphorylation-induced reduction of Eya1 SUMOylation.

  9. Low EYA1 expression is associated with gastric carcinoma.

  10. results showed evidence of weak association between the two SNPs of EYA1 (rs13260349 and rs2380716) and nonsyndromic orofacial clefts.

EYA1 Protein Profile

Protein Summary

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Four transcript variants encoding three distinct isoforms have been identified for this gene.

Alternative names and synonyms associated with EYA1

  • eyes absent homolog 1 (Drosophila) (EYA1)
  • eyes absent homolog 1 (eya1)
  • eyes absent 1 homolog (Drosophila) (Eya1)
  • eyes absent homolog 1 (Drosophila) (Eya1)
  • BOP protein
  • BOR protein
  • BOS1 protein
  • EYA1 protein
  • wu:fc13c10 protein
  • XEya1 protein
  • zgc:100770 protein

Protein level used designations for EYA1

eyes absent 1 , eyes absent homolog 1 (Drosophila) , eyes absent homolog 1 , eyes absent-1 , dog eared , eyes absent-1 beta , eyes absent 1 homolog

GENE ID SPECIES
472789 Pan troglodytes
100051446 Equus caballus
779594 Xenopus (Silurana) tropicalis
14048 Mus musculus
30436 Danio rerio
399175 Xenopus laevis
2138 Homo sapiens
502935 Rattus norvegicus
477910 Canis lupus familiaris
511188 Bos taurus
395718 Gallus gallus
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