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Human Filaggrin ELISA Kit for Sandwich ELISA - ABIN423702
Weichenthal, Ruether, Schreiber, Nair, Voorhees, Schwarz, Kabelitz, Christophers, Elder, Jenisch: Filaggrin R501X and 2282del4 mutations are not associated with chronic plaque-type psoriasis in a German cohort. in The Journal of investigative dermatology 2007
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CDC42 (show CDC42 ELISA Kits) is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardium formation.
MAPK (show MAPK1 ELISA Kits) cascades participate in osteogenesis, but only the ERK (show EPHB2 ELISA Kits) signaling pathway responds to FGFR1 (show FGFR1 ELISA Kits).
It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor (show FGFR2 ELISA Kits) 2, in the oligodendr
data suggest that FGF2 (show FGF2 ELISA Kits) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (show NR3C1 ELISA Kits) expression, an effect that is likely receptor mediated, albeit not by FGFR1 (show FGFR1 ELISA Kits), FGFR2 (show FGFR2 ELISA Kits), and FGFR3 (show FGFR3 ELISA Kits).
increased activity of the PI3K/AKT (show AKT1 ELISA Kits) signaling pathway in Pelo (show PELO ELISA Kits)-deficient skin might conflict with the dephosphorylation of profilaggrin and thereby affect its proper processing into filaggrin monomers and ultimately the epidermal differentiation
clearly demonstrate the different specificity of FGF12 (show FGF12 ELISA Kits)-FGFR1c2 and FGF22 (show FGF22 ELISA Kits)-FGFR1c2 for well defined HS structures and suggest that it is now possible to chemoenzymatically synthesize precise HS polysaccharides that can selectively mediate growth factor signaling
The study supports a pro-adipogenic role for betaKlotho (show KLB ELISA Kits) in skeletal muscle fibro/adipogenesis and calls for further research on involvement of the FGF-FGFR (show FGFR2 ELISA Kits)-betaKlotho (show KLB ELISA Kits) axis in the fibro/adipogenic infiltration associated with functional deterioration of skeletal muscle in aging and muscular dystrophy.
These new findings reveal that the FGF21-betaKlotho-FGFR1 signaling axis plays roles in maintaining phospholipid homeostasis and the dynamic functions of the lipid droplet, whereas protecting against ER stress, and suggest a potential link of phospholipid biosynthesis, lipid droplet dynamics, ER stress, and energy homeostasis in adipose tissue coordinated by this signaling axis.
Data suggest that Fgf1 (show FGF1 ELISA Kits)-mediated signaling represents an important signaling cascade related to adipogenesis and visceral adiposity; expression of Fgf1 (fibroblast growth factor 1 (show FGF1 ELISA Kits)) and Fgfr1 (fibroblast growth factor receptor 1 (show FGFR1 ELISA Kits)) is up-regulated in adipose tissue of obese mice (both obese mice due to high-fat diet and obese mice due to genetic deletion of leptin (show LEP ELISA Kits)).
FGFR1OP2 (show FGFR1OP2 ELISA Kits)-FGFR1 (show FGFR1 ELISA Kits) fusion in hematopoietic stem cells induced myeloid leukemia (show BCL11A ELISA Kits) and T-cell lymphoma in a mouse model.
FLG (show FGFR1 ELISA Kits) mutations are risk factors for atopic dermatitis in Finns, but disease severity and treatment response were independent of patient FLG (show FGFR1 ELISA Kits) status.
Patients with both atopic dermatitis and common filaggrin gene mutations are more frequently affected by reduced health-related quality of life
Multiple lines of evidence suggest that FLG (show FGFR1 ELISA Kits) genetic variation, have little or no effect on fitness in modern humans. Haplotype-level analysis revealed a recent selective sweep which increased the allele frequency of the Huxian haplogroup in Asian populations.
FLG (show FGFR1 ELISA Kits) mutations lead to alterations in epidermal eicosanoid metabolism in atopic dermatitis patients
Filaggrin gene mutations are risk factors for the presence and persistence of atopic dermatitis and explain the discordance of atopic dermatitis within dizygotic twin pairs.
Variations in FLG (show FGFR1 ELISA Kits) and TSLP (show TSLP ELISA Kits) genotype were associated with differences in self-reported skin clearance, TCI (show LXN ELISA Kits) usage, and steroid usage.
We show that subjects with FLG (show FGFR1 ELISA Kits)-null mutations have more mature Langerhans cells in nonlesional skin irrespective of whether they have AD.
we have proposed that this latitude-dependent gradient of FLG (show FGFR1 ELISA Kits) mutations across Europe, Asia and Africa could have provided an evolutionary advantage for heterozygous FLG (show FGFR1 ELISA Kits) mutation carriers, residing at northern latitudes, depletion of the FLG (show FGFR1 ELISA Kits) downstream product, trans-urocanic acid, would facilitate the intracutaneous synthesis of vitamin D3 by allowing increased transcutaneous absorption of UVB photons
The results of the present study demonstrate that filaggrin knockdown inhibits NHEK migration, adhesion and proliferation, promotes apoptosis and disturbs cell cycle progression.
FLG (show FGFR1 ELISA Kits) rs2065955 polymorphism was significantly related to gastric carcinoma.
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
, basic fibroblast growth factor receptor 1
, proto-oncogene c-Fgr
, epidermal filaggrin
, Filaggrin (profilaggrin)
, keratin intermediate filament-associated protein