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Human Polyclonal NDP Primary Antibody for EIA, IF - ABIN500373
Ohlmann, Scholz, Goldwich, Chauhan, Hudl, Ohlmann, Zrenner, Berger, Cvekl, Seeliger, Tamm: Ectopic norrin induces growth of ocular capillaries and restores normal retinal angiogenesis in Norrie disease mutant mice. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Show all 4 references for ABIN500373
Chicken Polyclonal NDP Primary Antibody for IHC, WB - ABIN2786504
Khan, Aldahmesh, Meyer: Correlation of ophthalmic examination with carrier status in females potentially harboring a severe Norrie disease gene mutation. in Ophthalmology 2008
we reported a novel missense NDP mutation of a familial case of Norrie Disease in a Chinese family.
hemizygous pathogenic variant in NDP, c.293 C>T, p.(Pro98Leu) was identified in two brothers with isolated bilateral microphthalmia and sclerocornea.
First study to demonstrate the involvement of NDP among patients with Indian familial exudative vitreoretinopathy (FEVR) that further expands its mutation spectrum.
These structural, biophysical and cellular data, map Fz4 (show FZD4 Antibodies) and putative Lrp5 (show LRP5 Antibodies)/6 binding sites to distinct patches on Norrin, and reveal a GAG binding site spanning Norrin and Fz4 (show FZD4 Antibodies) cysteine-rich domain.
Genetic evaluation of a case of bilateral leukocoria and asymmetric microphthalmia revealed a previously undescribed mutation in the Norrie disease protein gene.
Norrin may play a role in the regulation of angiogenesis.
Norrin induces the formation of a ternary complex with Fz4 (show FZD4 Antibodies) and Lrp5 (show LRP5 Antibodies)/6 by binding to their respective extracellular domains
Report of a missense mutation, p.Arg41Ser, in NDP causing Norrie disease in an Indian family.
Multi-functional norrin is a ligand for the LGR4 (show LGR4 Antibodies) receptor.
NDP mutations are common cause of Norrie disease but might be rare cause for familial exudative vitreoretinopathy (FEVR) in Chinese.
xNorrin promotes dorsal and anterior neural formation by acting on two major signaling pathways, Wnt (show WNT2 Antibodies) and TGF-beta (show TGFB1 Antibodies), in opposite ways and is essential for early neuroectoderm specification.
The endogenously expressed Lgr4 (show LGR4 Antibodies) may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin-mediated Lgr4 (show LGR4 Antibodies)-Wnt (show WNT2 Antibodies) signaling during gonadal development.
In this study we demonstrate, for the first time, that Norrin protein is expressed along the retinal blood vessels.
Taken together, we have uncovered a cell autonomous function for Ndp in retinal progenitor proliferation that is independent of its function in the retinal vasculature, which could explain the neural defects associated with Norrie disease
We conclude that constitutive overexpression of Norrin protects photoreceptors from light damage, an effect that is mediated by Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) and EDN2 (show EDN2 Antibodies) signaling and involves neurotrophic activities of BDNF (show BDNF Antibodies).
The data reveal both cell-autonomous and cell-nonautonomous effects, and they imply a central role for Norrin/Fz4 (show FZD4 Antibodies) signaling in central nervous system vascular development and in the maintenance of the blood brain barrier/blood retina barrier state.
Results suggest that the delayed outgrowth of the SRVP and decreased angiogenic sprouting in Norrin knockout (Ndp(y/-)) mice are direct effects of the reduced proliferation of endothelial cells from the superficial retinal vascular plexus (SRVP).
Norrin has a neuroprotective role for retinal neurons independent from its role on the growth of retinal capillaries.
These observations suggest the possibility that Norrin may have developmental and/or homeostatic functions beyond the retina and cochlea.
Norrin has pronounced neuroprotective properties on retinal neurons. The effects of Norrin involve activation of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling and subsequent induction of neurotrophic growth factors in Muller cells.
This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy.
X-linked exudative vitreoretinopathy 2 protein
, norrie disease protein
, Norrie disease protein
, norrie disease protein homolog
, Norrie disease homolog