Browse our Paired Box 3 Proteins (PAX3)

On are 8 Paired Box 3 (PAX3) Proteins from 5 different suppliers available. Additionally we are shipping Paired Box 3 Antibodies (150) and Paired Box 3 Kits (1) and many more products for this protein. A total of 170 Paired Box 3 products are currently listed.
CDHS, HUP2, Pax-3, pax3, pax3b, Sp, splotch, WS1, WS3, xpax3, xPax3-B, zgc:92547
list all proteins Gene Name GeneID UniProt
PAX3 5077 P23760
Rat PAX3 PAX3 114502  
PAX3 18505 P24610

Paired Box 3 Proteins (PAX3) by Origin

More Proteins for Paired Box 3 Interaction Partners

Horse (Equine) Paired Box 3 (PAX3) interaction partners

  1. No significant associations with coat color were found for PAX3 variants

  2. A novel missense variant, PAX3:p.Pro32Arg, in Appaloosa horses with a splashed white phenotype in addition to their leopard complex spotting patterns.

  3. several independent mutations in MITF (show MITF Proteins) and PAX3 together with known variants in the EDNRB (show EDNRB Proteins) and KIT genes explain a large proportion of horses with the more extreme white spotting phenotypes

Xenopus laevis Paired Box 3 (PAX3) interaction partners

  1. The pax3 and Pax7 (show PAX7 Proteins) paralogs cooperate in neural and neural crest patterning using distinct molecular mechanisms, in Xenopus laevis embryos.

Human Paired Box 3 (PAX3) interaction partners

  1. PAX3-FOXO1 (show FOXO1 Proteins) collaborates with MYCN (show MYCN Proteins) during early rhabdomyosarcoma (RMS) tumourigenesis to dysregulate proliferation and inhibit myogenic differentiation and cell death.

  2. The studies identify a P/CAF (show KAT2B Proteins)-PAX3-FOXO1 (show FOXO1 Proteins) signalling node that promotes oncogenesis and may contribute to MyoD (show MYOD1 Proteins) dysfunction in Alveolar rhabdomyosarcoma (ARMS).

  3. PAK3 mutation has a role in intellectual disability and macrocephaly in monozygotic twins [family case report with two affected patients]

  4. Pax3 regulates GFAP (show GFAP Proteins) expression.

  5. FOXD3 (show FOXD3 Proteins) is sufficient but not necessary to drive PAX3 expression in melanoma cells.

  6. Secreted Frizzled-Related Protein 3 (SFRP3 (show FRZB Proteins)) Is Required for Tumorigenesis of PAX3-FOXO1 (show FOXO1 Proteins)-Positive Alveolar Rhabdomyosarcoma

  7. findings suggest a tumor suppressor role for APC (show APC Proteins)/C(Cdh1 (show CDH1 Proteins)) in melanocytes and that targeting PAX3 may be a strategy for treating melanoma.

  8. PAX3 phosphorylation has a role in determing melanoma phenotypes by affecting proliferation, invasion, and transformation

  9. All affected members of pedigree IR-WS-20 carried the mutation c.1024_1040 del AGCACGATTCCTTCCAA in exon 7 of PAX3, while none of the unaffected members and 50 of the ethnic matched controls tested had this deletion.

  10. PAX3 differentially regulates various downstream target genes involved in cell proliferation in melanoma cells compared to melanocytes.

Cow (Bovine) Paired Box 3 (PAX3) interaction partners

  1. SNP and haplotype analysis of PAX3 gene provide evidence for association with growth traits in Chinese cattle.

Mouse (Murine) Paired Box 3 (PAX3) interaction partners

  1. Sequence analysis identified a missense point mutation (c.101G>A) in exon 2 of Pax3 that resulted in a methionine to isoleucine conversion at amino acid 62 of the PAX3 protein

  2. This study show that Pax3+ satellite cells retain long-term self-renewal ability and express slow-MyHC isoforms after differentiation.

  3. Pax3 enhances expression of Polysialic acid on neural cell adhesion molecule (show MCAM Proteins) in NMuMG cells by upregulating ST8Sia II (show ST8SIA2 Proteins) expression and downregulating ST8Sia IV (show ST8SIA4 Proteins) expression.

  4. PAX3 role in neural tube defects

  5. The Pax3(GFP) allele proved to be a convenient marker to identify and directly sort heterogeneous populations of melanoma cells within the tumor bulk at each stage of melanoma progression.

  6. deletion of Foxc1 (show FOXC1 Proteins) and Foxc2 (show FOXC2 Proteins) specifically in Pax3-positive cells affects cell fate choices in the dermomyotome of somites at forelimb level, promoting the myogenic cell fate at the expense of endothelial cells that migrate to the limb

  7. findings suggest a tumor suppressor role for APC (show APC Proteins)/C(Cdh1 (show CDH1 Proteins)) in melanocytes and that targeting PAX3 may be a strategy for treating melanoma.

  8. These results demonstrate a requirement for endoglin (show ENG Proteins) in descendants of Pax3-expressing vascular cell precursors.

  9. Results suggest that regional Pax3 expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B (show PDGFB Proteins)-induced brainstem gliomagenesis

  10. we show that the ability of Pax3 to induce the skeletal myogenic cell fate occurs at the expenses of the cardiac lineage.

Zebrafish Paired Box 3 (PAX3) interaction partners

  1. BMP, Wnt (show WNT2 Proteins) and FGF signaling are needed for expression of the neural plate border specifiers pax3a and zic3 (show ZIC3 Proteins) in zebrafish

  2. evidence of YAP's role in regulating pax3 neural crest expression

  3. Pax3 in zebrafish is required for specification of two specific lineages of neural crest, xanthophores and enteric neurons.

Paired Box 3 (PAX3) Protein Profile

Protein Summary

This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2\;13)(q35\;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.

Alternative names and synonyms associated with Paired Box 3 (PAX3)

  • paired box 3 (PAX3)
  • paired box 3 (pax3)
  • paired box 3 (pax3-b)
  • paired box 3 (Pax3)
  • paired box gene 3 (Pax3)
  • paired box gene 3a (pax3a)
  • CDHS protein
  • HUP2 protein
  • Pax-3 protein
  • pax3 protein
  • pax3b protein
  • Sp protein
  • splotch protein
  • WS1 protein
  • WS3 protein
  • xpax3 protein
  • xPax3-B protein
  • zgc:92547 protein

Protein level used designations for Paired Box 3 Proteins (PAX3)

paired box 3 , paired box protein 3 , paired box gene 3 (Waardenburg syndrome 1) , Paired-domain transcription factor Pax3 , Waardenburg syndrome 1 , paired box protein Pax-3 , paired-box 3 , paired box protein Pax-3-like , paired box 3 b , paired box protein Pax-3-B , paired-domain transcription factor Pax3-B , paired box gene 3 , paired box homeotic gene 3 , paired domain gene 3 , paired domain gene HuP2 , paired-box 3 protein , homeodomain protein PAX3 , etID309899.2

414901 Sus scrofa
448464 Xenopus (Silurana) tropicalis
459971 Pan troglodytes
705315 Macaca mulatta
100056517 Equus caballus
100357318 Oryctolagus cuniculus
100406473 Callithrix jacchus
100468866 Ailuropoda melanoleuca
100560571 Anolis carolinensis
100591131 Nomascus leucogenys
496377 Xenopus laevis
374127 Gallus gallus
5077 Homo sapiens
488544 Canis lupus familiaris
540951 Bos taurus
114502 Rattus norvegicus
18505 Mus musculus
30532 Danio rerio
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