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TBL1 deficiency resulted in inhibition of fatty acid oxidation due to impaired functional cooperation with its heterodimerization partner TBL-related (TBLR) 1 (show TBL1XR1 Proteins) and the nuclear receptor peroxisome proliferator-activated receptor (show PPARG Proteins) (PPAR) alpha (show PPARA Proteins)
TBLR1 (show TBL1XR1 Proteins) and TBL1 have roles in specific nuclear receptor-mediated gene activation events
TBL1X mutations are associated with central hypothyroidism and hearing loss.
Here, the authors show that transcriptional co-factor Transducin (show GNAT1 Proteins) beta-like (TBL) 1 was over-expressed in both human and murine pancreatic ductal adenocarcinoma and TBL1 deficiency both prevented and reversed pancreatic tumor growth.
TBL1 is required to protect GPS2 (show GPS2 Proteins) from degradation, with methylation of GPS2 (show GPS2 Proteins) by arginine methyltransferase PRMT6 (show PRMT6 Proteins) regulating the interaction with TBL1 and inhibiting proteasome-dependent degradation.
We localized proteins encoded by the top two regulated genes, TBL1X and USH1C (show USH1C Proteins), using immunohistochemistry to placental stem and anchoring villi associated with active contractile function.
TBL1 and TBLR1 (show TBL1XR1 Proteins) are functionally redundant and essential for transcriptional repression by unliganded thyroid hormone (show PTH Proteins) receptors (TR) but not essential for transcriptional activation by liganded TR
Mutations within the LisH (LIS1 (show PAFAH1B1 Proteins) homology)motif of TBL 1X are likely to result in pathogenic consequences in genes associated with genetic diseases.
Wnt (show WNT2 Proteins) signalling induced the interaction between beta-catenin (show CTNNB1 Proteins) and TBL1-TBLR1 (show TBL1XR1 Proteins), as well as their binding to Wnt (show WNT2 Proteins) target genes. Importantly, the recruitment of TBL1-TBLR1 (show TBL1XR1 Proteins) and beta-catenin (show CTNNB1 Proteins) to Wnt (show WNT2 Proteins) target-gene promoters was mutually dependent on each other.
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.
F-box-like/WD repeat-containing protein TBL1X
, transducin (beta)-like 1X-linked
, transducin beta-like 1X
, F-box-like/WD repeat-containing protein TBL1X-like
, f-box-like/WD repeat-containing protein TBL1X-like
, transducin beta-like protein 1X
, transducin-beta-like protein 1, X-linked
, transducin beta-like 1