Browse our TMIE Proteins (TMIE)

Full name:
Transmembrane Inner Ear Proteins (TMIE)
On are 4 Transmembrane Inner Ear (TMIE) Proteins from 3 different suppliers available. Additionally we are shipping TMIE Antibodies (21) and many more products for this protein. A total of 25 TMIE products are currently listed.
5131400L21Rik, DFNB6, Mm.87012, RGD1562523, si:ch211-163f10.1, sr
list all proteins Gene Name GeneID UniProt
TMIE 259236 Q8NEW7
TMIE 20776 Q8K467
Rat TMIE TMIE 501061  

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TMIE Proteins (TMIE) by Origin

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More Proteins for TMIE Interaction Partners

Zebrafish Transmembrane Inner Ear (TMIE) interaction partners

  1. an early frameshift mutation in tmie discovered in a line of deaf and uncoordinated zebrafish with defective hair-cell function

  2. Data show that transmembrane inner ear (tmie)appears to be required for inner ear development and function in the zebrafish and for hair cell maturation in the vestibular and lateral line systems as well.

Human Transmembrane Inner Ear (TMIE) interaction partners

  1. Description of the spectrum of mutations in TMIE in 374 families with autosomal recessive, non-syndromic hearing loss from India.

  2. genetic mapping data support human TMIE as the gene affected at DFNB6, a non-syndromic hearing loss locus

  3. identification of 5 different homozygous recessive mutations in a novel gene, TMIE= transmembrane inner ear expressed gene, in affected members of consanguineous families segregating severe-to-profound prelingual deafness, consistent with linkage to DFNB6

  4. The circling mouse is a potential animal model for DFNB6 deafness in humans.

Mouse (Murine) Transmembrane Inner Ear (TMIE) interaction partners

  1. This study demonistrated that TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells.

  2. Tmie is required for maturation and maintenance of hair cells.

  3. Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6.

  4. characterized the circling mutation as a 40-kilobase deletion that includes the transmembrane inner ear (tmie) gene

  5. These results clearly indicate that tmie protein plays an important role when the appropriate expression level of tmie was expressed in the inner ear.

TMIE Protein Profile

Protein Summary

This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment.

Alternative names and synonyms associated with TMIE

  • transmembrane inner ear (tmie)
  • transmembrane inner ear (TMIE)
  • transmembrane inner ear (Tmie)
  • 5131400L21Rik protein
  • DFNB6 protein
  • Mm.87012 protein
  • RGD1562523 protein
  • si:ch211-163f10.1 protein
  • sr protein

Protein level used designations for Transmembrane Inner Ear Proteins (TMIE)

transmembrane inner ear expressed protein , transmembrane inner ear , transmembrane inner ear protein , spinner

555430 Danio rerio
609350 Canis lupus familiaris
617572 Bos taurus
740562 Pan troglodytes
769596 Gallus gallus
259236 Homo sapiens
20776 Mus musculus
501061 Rattus norvegicus
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