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anti-Human EPAS1 Antibodies:
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Hamster Monoclonal EPAS1 Primary Antibody for ChIP, ELISA - ABIN151063
Bernhardt, Wiesener, Weidemann, Schmitt, Weichert, Lechler, Campean, Ong, Willam, Gretz, Eckardt: Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. in The American journal of pathology 2007
Show all 146 Pubmed References
Fish Polyclonal EPAS1 Primary Antibody for ChIP, ELISA - ABIN151051
Conrad, Freeman, Beitner-Johnson, Millhorn: EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. in The Journal of biological chemistry 1999
Show all 478 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody for ELISA, IHC - ABIN250056
Harvey, Kind, Pantaleon, Armstrong, Thompson: Oxygen-regulated gene expression in bovine blastocysts. in Biology of reproduction 2004
Show all 19 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody for ELISA, ICC - ABIN250055
Mekhail, Gunaratnam, Bonicalzi, Lee: HIF activation by pH-dependent nucleolar sequestration of VHL. in Nature cell biology 2004
Show all 15 Pubmed References
Fish Polyclonal EPAS1 Primary Antibody for ELISA, ICC - ABIN249868
Alvarez-Tejado, Naranjo-Suarez, Jiménez, Carrera, Landázuri, del Peso: Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. in The Journal of biological chemistry 2001
Show all 17 Pubmed References
Human Monoclonal EPAS1 Primary Antibody for IHC (fro), IHC (p) - ABIN1742588
Wiesener, Turley, Allen, Willam, Eckardt, Talks, Wood, Gatter, Harris, Pugh, Ratcliffe, Maxwell: Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. in Blood 1998
Show all 4 Pubmed References
Human Monoclonal EPAS1 Primary Antibody for IHC (p) - ABIN2473999
Pike, Phadwal, Simon, Harris: ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia. in Molecular biology reports 2012
Hamster Monoclonal EPAS1 Primary Antibody for ELISA, FACS - ABIN406865
Su, Li, Cui, Ji, Geng, Chai, Ma, Bai, Yang, Wuren, Ge, Rondina: The Local HIF-2α/EPO Pathway in the Bone Marrow is Associated with Excessive Erythrocytosis and the Increase in Bone Marrow Microvessel Density in Chronic Mountain Sickness. in High altitude medicine & biology 2015
Human Polyclonal EPAS1 Primary Antibody for IF (p), IHC (p) - ABIN686662
Li, Chen, Shao, Tang, Chen, Chen, Xu: Oxidative stress induces the decline of brain EPO expression in aging rats. in Experimental gerontology 2016
Human Monoclonal EPAS1 Primary Antibody for AA, ELISA - ABIN863099
Kim, Perera, Zhou, Carretero, Yeh, Heathcote, Jackson, Nikolinakos, Ospina, Naumov, Brandstetter, Weigman, Zaghlul, Hayes, Padera, Heymach, Kung, Sharpless, Kaelin, Wong: HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. in The Journal of clinical investigation 2009
Show all 4 Pubmed References
findings suggest the HIF-2alpha pathway predominates over HIF-1alpha (show HIF1A Antibodies) signalling in neuronal-like cells following acute hypoxia
these findings demonstrated that HIF-2alpha in vselMSCs cooperated with Oct4 (show POU5F1 Antibodies) in survival and function. The identification of the cooperation between HIF-2alpha and Oct4 (show POU5F1 Antibodies) will lead to deeper characterization of the downstream targets of this interaction in vselMSCs and will have novel pathophysiological implications for the repair of infarcted myocardium.
findings indicate that HIF-2alpha increases cancer cell growth by up-regulating YAP1 (show YAP1 Antibodies) activity
Findings show that hypoxia inducible factor 1 alpha subunit (HIF-1alpha (show HIF1A Antibodies)) is phylogenetically conserved among most metazoans, whereas HIF-2alpha protein appeared later.
proteomic experiments on Normoxic Neuroblastoma (show ARHGEF16 Antibodies) cells to investigate HIF-2alpha downstream-regulated proteins or pathways
HIF1A (show HIF1A Antibodies) and HIF2A contribute to cancer stem cells survival but play different roles -HIF1A (show HIF1A Antibodies) being more responsible for survival functions and HIF2A for self-renewal [review].
The negative feedback modulation between LncRNA-SARCC/AR complex and HIF-2alpha signaling may then lead to differentially modulated RCC (show XRCC1 Antibodies) progression in a VHL (show VHL Antibodies)-dependent manner. Together, these results may provide us a new therapeutic approach via targeting this newly identified signal from LncRNA-SARCC to AR-mediated HIF-2alpha/C-MYC (show MYC Antibodies) signals against RCC (show XRCC1 Antibodies) progression.
Results suggested that the oncogenic transcription factor HIF-2alpha stabilized VHL (show VHL Antibodies) disease suppressor B-Myb (show MYBL2 Antibodies), which is also a transcription factor, by physical interaction. Some B-Myb (show MYBL2 Antibodies)-dependent gene expression was similarly affected by B-Myb (show MYBL2 Antibodies) or HIF-2alpha knockdown, suggesting that stabilization of B-Myb (show MYBL2 Antibodies) by HIF-2alpha may play a role in specific gene expressions.
Data suggest a common mechanism by which DNA methyltransferase1 (DNMT1 (show DNMT1 Antibodies)) and hypoxia inducible factors HIF1alpha (show HIF1A Antibodies)/HIF2alpha regulate Sprouty2 (Spry2 (show SPRY2 Antibodies)) transcription.
Hypoxia microenvironment in hepatocellular carcinoma up-regulates HIF2/SCF (show KITLG Antibodies) expression, which in turn promotes angiogenesis and HCC (show FAM126A Antibodies) metastasis.
Chronic activity of HIF2 in stromal progenitors impairs kidney development. Finally, these data confirm the concept that normal stroma function is essential for normal tubular differentiation.
this study shows that HIF-2alpha acts in resting macrophages as a phagocytosis suppressor implying an important relationship between the levels of HIF-2alpha and susceptibility to infection
in neurons HIF-1 (show HIF1A Antibodies) and HIF-2 have redundant functions for cellular survival under ischemic conditions. By contrast, lack of anti-survival factors in Hif1a (show HIF1A Antibodies)/Hif2a-deficient mice might protect from early acute neuronal cell death and neurological impairment, indicating a benefit of HIF-pathway inhibition in neurons in the very acute phase after ischemic stroke
HIF-2alpha is a novel regulator of neutrophil recruitment to colon tumors.
AQP1 (show AQP1 Antibodies) deficiency delays long-term ischemia-reperfusion resolution, partly through repressing angiogenesis mediated by destabilizing HIF-2alpha.
HIF1alpha (show HIF1A Antibodies) and HIF2alpha are dispensable for muscle stem cell function under normoxia but are required for maintaining satellite cell self-renewal in hypoxic environments.
eIF3e (show EIF3E Antibodies) is an angiogenesis suppressor. Silencing of eIF3e (show EIF3E Antibodies) promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2alpha activity.
The regulatory connection between HIF-2alpha and VEGFR-1 (show FLT1 Antibodies), VEGFR-2 (show KDR Antibodies) and MMP2 (show MMP2 Antibodies).
HIF2alpha is essential for the acute postprandial regulation of hepatic glucagon (show GCG Antibodies) signaling.
immunostaining for HIF-1alpha (show HIF1A Antibodies) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification
There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
endothelial PAS domain protein 1
, endothelial PAS domain-containing protein 1-like
, HIF-1-alpha-like factor
, HIF-1alpha-like factor
, PAS domain-containing protein 2
, basic-helix-loop-helix-PAS protein MOP2
, class E basic helix-loop-helix protein 73
, endothelial PAS domain-containing protein 1
, hypoxia-inducible factor 2 alpha
, hypoxia-inducible factor 2-alpha
, member of PAS protein 2
, HIF-related factor
, HIF1 alpha-like factor
, HIF1alpha-like factor
, HLF (HIF1alpha-like factor)
, Hif like protein
, hypoxia inducible transcription factor 2alpha
, HIF-2 alpha
, HIF2 alpha
, hypoxia inducible factor 2, alpha subunit
, hypoxia inducible factor 2a