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anti-Human S1PR1 Antibodies:
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Mouse (Murine) Monoclonal S1PR1 Primary Antibody for CyTOF, FACS - ABIN4900842
Maeda, Seki, Kataoka, Takemoto, Utsumi, Fukunari, Sugahara, Chiba: IL-17-Producing Vγ4+ γδ T Cells Require Sphingosine 1-Phosphate Receptor 1 for Their Egress from the Lymph Nodes under Homeostatic and Inflammatory Conditions. in Journal of immunology (Baltimore, Md. : 1950) 2015
Show all 6 Pubmed References
Human Polyclonal S1PR1 Primary Antibody for WB - ABIN264982
Liu, Wada, Yamashita, Mi, Deng, Hobson, Rosenfeldt, Nava, Chae, Lee, Liu, Hla, Spiegel, Proia: Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. in The Journal of clinical investigation 2000
Show all 9 Pubmed References
Human Monoclonal S1PR1 Primary Antibody for CyTOF, FACS - ABIN4899114
Williams, Stilhano, To, Tran, Wong, Silva: Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P). in PLoS ONE 2015
Show all 4 Pubmed References
Human Monoclonal S1PR1 Primary Antibody for CyTOF, FACS - ABIN4899115
Cabezón, Sintes, Llinàs, Benitez-Ribas: Analysis of HLDA9 mAbs on plasmacytoid dendritic cells. in Immunology letters 2010
Show all 4 Pubmed References
Mouse (Murine) Monoclonal S1PR1 Primary Antibody for FACS - ABIN4898837
Cuenca, Romero, Sintes, Terhorst, Engel: Targeting of Ly9 (CD229) Disrupts Marginal Zone and B1 B Cell Homeostasis and Antibody Responses. in Journal of immunology (Baltimore, Md. : 1950) 2016
Show all 3 Pubmed References
Human Polyclonal S1PR1 Primary Antibody for IHC (p) - ABIN4351829
Hildebrandt, Gheber, Kingsbury, Hoyt: Homotetrameric form of Cin8p, a Saccharomyces cerevisiae kinesin-5 motor, is essential for its in vivo function. in The Journal of biological chemistry 2006
Show all 2 Pubmed References
Human Monoclonal S1PR1 Primary Antibody for FACS - ABIN4895626
Llinàs, Lázaro, de Salort, Matesanz-Isabel, Sintes, Engel: Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry. in Immunology letters 2010
Zebrafish (Danio rerio) Polyclonal S1PR1 Primary Antibody for WB - ABIN1881771
Im, Ungar, Lynch: Characterization of a zebrafish (Danio rerio) sphingosine 1-phosphate receptor expressed in the embryonic brain. in Biochemical and biophysical research communications 2000
Human Polyclonal S1PR1 Primary Antibody for ICC, IF - ABIN4351831
Awojoodu, Ogle, Sefcik, Bowers, Martin, Brayman, Lynch, Peirce-Cottler, Botchwey: Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis. in Proceedings of the National Academy of Sciences of the United States of America 2013
These findings are consistent with a model in which signalling via S1P (show MBTPS1 Antibodies) and S1PR1 are integral components in the response of lymphatic endothelial cells to the stimulus provided by fluid flow.
S1PR1/3 silencing alters proliferation, adhesion, viability and lateral motility in estrogen receptor (show ESR1 Antibodies)-negative MCF-7 and estrogen receptor (show ESR1 Antibodies)-positive MDA-MB-231 breast cancer cells.
Activated S1PR1 signaling regulates the production of cellular adhesion molecules by inhibiting NF- kappaB (show NFKB1 Antibodies) activation via a beta (show SUCLA2 Antibodies)-arrestin2 (show ARRB2 Antibodies)-dependent manner
Model recombinant HDL (show HSD11B1 Antibodies) (rHDL) particles formed in vitro with S1P (show MBTPS1 Antibodies) incorporated into the particle initiated the internalization of S1PR1, whereas rHDL without supplemented S1P (show MBTPS1 Antibodies) did not, suggesting that S1P (show MBTPS1 Antibodies) transported in HDL (show HSD11B1 Antibodies) can selectively activate S1PR1.
Blocking of S1PR activity and inhibition of S1P (show MBTPS1 Antibodies) synthesis led to decreased expression of fibrosis and tissue remodeling-related proteins in primary cultures of orbital fibroblasts derived from patients with GO.
a lipid molecule repeatedly entered the receptor between the extracellular ends of TM1 (show TPM2 Antibodies) and TM7, providing important insights into the pathway of ligand entry into the S1PR1 .
Mature human thymocytes rely on S1P (show MBTPS1 Antibodies)-R1 to migrate toward S1P (show MBTPS1 Antibodies). Taken in the context of murine work demonstrating that S1P (show MBTPS1 Antibodies) is required for thymocyte egress to the periphery.
ApoM (show APOM Antibodies)-bound sphingosine-1-phosphate regulates adhesion molecule (show NCAM1 Antibodies) abundance, leukocyte-endothelial adhesion, and endothelial barrier function via sphingosine-1-phosphate receptor1.
The S1P1,3 activation results in Akt (show AKT1 Antibodies) phosphorylation and subsequent activation of eNOS (show NOS3 Antibodies) via phosphorylation at serine(1177) and dephosphorylation at threonine(495).
HDL (show HSD11B1 Antibodies)-associated ApoM (show APOM Antibodies) is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 and S1P3 (show S1PR3 Antibodies) receptors on vascular endothelium.
these data demonstrate that chronic inflammation modulates S1P1 expression and tissue S1P levels
promotes lymphangiogenesis and metastasis via NLRP3 (show NLRP3 Antibodies)/IL-1beta (show IL1B Antibodies) in tumor-associated macrophages
The study suggests that vascular leakage of albumin (show ALB Antibodies)-sized particles in ApoM (show APOM Antibodies) deficiency is S1P- and S1P1-dependent and this dependency exacerbates the response to inflammatory stimuli.
The present results suggest that Fas (show FAS Antibodies)/S1P1 signaling via activation of NF-kappaB (show NFKB1 Antibodies) in osteoclast precursor cells is a key factor in the pathogenesis of rheumatoid arthritis in the temporomandibular joint.
Activation of the S1P1 receptor in cardiac mast cells confers cardio-protection during cardiac mast cell degranulation.
this study shows that S1P1 downregulation mirrors the strength and persistence of the TCR stimulation, limiting egress of high affinity T cells from lymph nodes
After axonal damage, S1PR1 expression was decreased in retinal neurons
These results indicate a role for S1P signaling in Bordetella pertussis-mediated pathology.
These results suggest that S1P signaling via S1P1 in cardiomyocytes plays a previously unknown and necessary role in heart development in mice in expansion of cardiomyocyte number and ventricular compaction.
Profound depletion of S1p renders both erythrocyte and platelet pools necessary for recovery during anaphylactic shock.
Polymorphisms in promoter regions of PDHB (show PDHB Antibodies), SORBS1 (show SORBS1 Antibodies), and EDG1 genes showing marbling-associated expression changes.
we detected 2 novel SNPs, referred to as g.1475435G>A and g.1471620G>T, in the 5' flanking region of the EDG1 between low-marbled and high-marbled steer groups
EDG1 SNPs, although they may not be regarded as a causal mutation, may be useful for effective marker-assisted selection to increase the levels of marbling in Japanese Black beef cattle.
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.
S1P receptor 1
, S1P receptor Edg-1
, endothelial differentiation G-protein coupled receptor 1
, endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
, sphingosine 1-phosphate receptor 1
, sphingosine 1-phosphate receptor EDG1
, sphingosine 1-phosphate receptor Edg-1
, sphingosine-1-phosphate receptor 1
, endothelial differentiation sphingolipid G-protein-coupled receptor 1
, lysophospholipid receptor B1
, EDG1 (Edg1)
, Sphingosine 1-phosphate receptor Edg-1
, sphingosine-1-phosphate receptor 1 L homeolog