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anti-Human Thymidine Phosphorylase Antibodies:
anti-Rat (Rattus) Thymidine Phosphorylase Antibodies:
anti-Mouse (Murine) Thymidine Phosphorylase Antibodies:
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Human Monoclonal Thymidine Phosphorylase Primary Antibody for IHC (p), IP - ABIN5590451
Fox, Westwood, Moghaddam, Comley, Turley, Whitehouse, Bicknell, Gatter, Harris: The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase is up-regulated in breast cancer epithelium and endothelium. in British journal of cancer 1996
Human Monoclonal Thymidine Phosphorylase Primary Antibody for ICC, IF - ABIN251182
Nie, Bhat, Al-Saleem, Vonderheid, Hou: Expression of thymidine phosphorylase in lymph nodes involved with mycosis fungoides and sézary syndrome. in Advances in hematology 2011
S1PR1 (show S1PR1 Antibodies)/3 silencing alters proliferation, adhesion, viability and lateral motility in estrogen receptor (show ESR1 Antibodies)-negative MCF-7 and estrogen receptor (show ESR1 Antibodies)-positive MDA-MB-231 breast cancer cells.
TP expression is associated with tumor stage, histological grade and thrombocytosis in patients with renal cell carcinoma (show MOK Antibodies)
Activated S1PR1 (show S1PR1 Antibodies) signaling regulates the production of cellular adhesion molecules by inhibiting NF- kappaB (show NFKB1 Antibodies) activation via a beta (show SUCLA2 Antibodies)-arrestin2 (show ARRB2 Antibodies)-dependent manner
Studied the role of thymidine phosphorylase (TP) in promoting the invasion and metastasis of hepatocellular carcinoma (HCC (show FAM126A Antibodies)). It was shown that TP correlated with MMP2 (show MMP2 Antibodies) and MMP9 (show MMP9 Antibodies) expression, and that TP mediated the migration of tumor cells through activity of MMPs in HCC (show FAM126A Antibodies) cell lines.
Model recombinant HDL (show HSD11B1 Antibodies) (rHDL) particles formed in vitro with S1P (show MBTPS1 Antibodies) incorporated into the particle initiated the internalization of S1PR1 (show S1PR1 Antibodies), whereas rHDL without supplemented S1P (show MBTPS1 Antibodies) did not, suggesting that S1P (show MBTPS1 Antibodies) transported in HDL (show HSD11B1 Antibodies) can selectively activate S1PR1 (show S1PR1 Antibodies).
Blocking of S1PR activity and inhibition of S1P (show MBTPS1 Antibodies) synthesis led to decreased expression of fibrosis and tissue remodeling-related proteins in primary cultures of orbital fibroblasts derived from patients with GO.
a lipid molecule repeatedly entered the receptor between the extracellular ends of TM1 (show TPM2 Antibodies) and TM7, providing important insights into the pathway of ligand entry into the S1PR1 (show S1PR1 Antibodies) .
Mature human thymocytes rely on S1P (show MBTPS1 Antibodies)-R1 to migrate toward S1P (show MBTPS1 Antibodies). Taken in the context of murine work demonstrating that S1P (show MBTPS1 Antibodies) is required for thymocyte egress to the periphery.
ApoM (show APOM Antibodies)-bound sphingosine-1-phosphate regulates adhesion molecule (show NCAM1 Antibodies) abundance, leukocyte-endothelial adhesion, and endothelial barrier function via sphingosine-1-phosphate receptor1.
The S1P1,3 activation results in Akt (show AKT1 Antibodies) phosphorylation and subsequent activation of eNOS (show NOS3 Antibodies) via phosphorylation at serine(1177) and dephosphorylation at threonine(495).
data identify TYMP as an astrocyte-derived permeability factor, and suggest TYMP and VEGFA (show VEGFA Antibodies) together promote blood-brain barrier breakdown.
TYMP participates in multiple platelet signaling pathways and regulates platelet activation and thrombosis. Targeting TYMP might be a novel antiplatelet and antithrombosis therapy.
Thymidine phosphorylase and UPP1 (show UPP1 Antibodies) double knockout mice showed increased thymidine and deoxyuridine in tissues and developed encephalopathy.
This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified.
, Thymidine phosphorylase
, S1P receptor 1
, S1P receptor Edg-1
, endothelial differentiation G-protein coupled receptor 1
, endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
, sphingosine 1-phosphate receptor 1
, sphingosine 1-phosphate receptor EDG1
, sphingosine 1-phosphate receptor Edg-1
, endothelial cell growth factor 1 (platelet-derived)
, platelet derived growth factor, endothelial cell