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Collectively, our study identified an unexpected transcriptional repression function of the BET bromodomain and a novel mechanism for TAZ (show TAZ Proteins) upregulation.
is not a Notch ligand (show JAG2 Proteins)
DNER rs1861612 C to T change and variant T genotype may contribute to T2DM in a Chinese Han population
These studies implicate DNER as a susceptibility gene for T2DM in American Indians.
Our data suggest that clathrin-independent endocytosis is critical for the polarized targeting of somatodendritic proteins(DNER).
The inhibition of DNER protein resulted in an increase in adipocyte maturation, partly via a reduction of cell proliferation through elevation of CCAAT-Enhancer-Binding Protein-delta (show CEBPD Proteins) expression.
DNER plays a redundant role with other Notch (show NOTCH1 Proteins) ligands in cochlear development
DNER mediates neuron-glia interaction and promotes morphological differentiation of Bergmann glia through Deltex (show DTX1 Proteins)-dependent Notch (show NOTCH1 Proteins) signaling.
These observations suggest that pleiotrophin (show PTN Proteins)-PTPzeta (show PTPRZ1 Proteins) signaling controls subcellular localization of DNER and thereby regulates neuritogenesis.
Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling.
delta-notch-like EGF repeat-containing transmembrane
, delta and Notch-like epidermal growth factor-related receptor
, delta/notch-like EGF-related receptor
, brain EGF repeat-containing transmembrane protein
, transmembrane protein Bet