DNER Protein (Fc Tag,His tag)

Catalog No. ABIN7534322

Product Details

Target: DNER (delta/notch-Like EGF Repeat Containing (DNER))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This DNER protein is labelled with Fc Tag,His tag.

Purpose: Recombinant Human DNER Protein

Sequence: RGSSLANPVP AAPLSAPGPC AAQPCRNGGV CTSRPEPDPQ HPAPAGEPGY SCTCPAGISG ANCQLVADPC ASNPCHHGNC SSSSSSSSDG YLCICNEGYE GPNCEQALPS LPATGWTESM APRQLQPVPA TQEPDKILPR SQATVTLPTW QPKTGQKVVE MKWDQVEVIP DIACGNASSN SSAGGRLVSF EVPQNTSVKI RQDATASLIL LWKVTATGFQ QCSLIDGRSV TPLQASGGLV LLEEMLALGN NHFIGFVNDS VTKSIVALRL TLVVKVSTCV PGESHANDLE CSGKGKCTTK PSEATFSCTC EEQYVGTFCE EYDACQRKPC QNNASCIDAN EKQDGSNFTC VCLPGYTGEL CQSKIDYCIL DPCRNGATCI SSLSGFTCQC PEGYFGSACE EKVDPCASSP CQNNGTCYVD GVHFTCNCSP GFTGPTCAQL IDFCALSPCA HGTCRSVGTS YKCLCDPGYH GLYCEEEYNE CLSAPCLNAA TCRDLVNGYE CVCLAEYKGT HCELYKDPCA NVSCLNGATC DSDGLNGTCI CAPGFTGEEC DIDINECDSN PCHHGGSCLD QPNGYNCHCP HGWVGANCEI HLQWKSGHMA ESLTNMPRH

Specificity: Arg29-His637

Purity: > 97 % by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: < 0.01 EU/μg of the protein by LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Target Details

Target: DNER (delta/notch-Like EGF Repeat Containing (DNER))

Alternative Name: DNER (DNER Products)

Synonyms: UNQ26 Protein, bet Protein, A930026D19Rik Protein, BET Protein, Bret Protein, delta/notch like EGF repeat containing Protein, delta and Notch-like epidermal growth factor-related receptor Protein, delta/notch-like EGF repeat containing Protein, DNER Protein, LOC540552 Protein, Dner Protein

Background:

Description: DNER (Delta/Notch-like EGF-related receptor), also known as BET (brain-specific EGF-like transmembrane protein), is a type I transmembrane glycoprotein of the Notch/Delta family . In the mouse, DNER has been detected as 90, 120 and 150 kDa forms which are probably variably glycosylated .Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.DNER associates with protein tyrosine phosphatase zeta (PTP zeta ), which is the receptor of pleiotrophin (PTN). PTP zeta -PTN-DNER signaling has been implicated in the regulation of neuritogenesis. Expression of DNER in glioblastoma stem-like cells inhibits formation of neurospheres in vitro, while in vivo it induces differentiation and inhibits growth of xenografts, thus acting as a tumor suppressor.

Name: DNER,UNQ26,bet

Gene ID: 92737

UniProt: Q8NFT8

Pathways: Skeletal Muscle Fiber Development