Browse our LAMB2 Proteins (LAMB2)

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Laminin, beta 2 (Laminin S) Proteins (LAMB2)
On are 13 Laminin, beta 2 (Laminin S) (LAMB2) Proteins from 4 different suppliers available. Additionally we are shipping LAMB2 Antibodies (89) and LAMB2 Kits (10) and many more products for this protein. A total of 115 LAMB2 products are currently listed.
AW211941, Lamb-2, LAMC1, laminin, LAMS, NPHS5, SLAM
list all proteins Gene Name GeneID UniProt
LAMB2 25473 P15800
LAMB2 16779 Q61292
LAMB2 3913 P55268

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LAMB2 Proteins (LAMB2) by Origin

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More Proteins for LAMB2 Interaction Partners

Mouse (Murine) Laminin, beta 2 (Laminin S) (LAMB2) interaction partners

  1. Loss of Lamb2 alters calcium sensitivity and voltage-gated calcium channel maturation of neurotransmission at the neuromuscular junction

  2. Isolated a novel mouse strain with a viable nephrotic phenotype and used whole-genome sequencing to isolate a causative hypomorphic mutation in Lamb2 in hereditary nephrotic syndrome.

  3. mild variant of Pierson syndrome caused by the C321R-LAMB2 mutation may be a prototypical ER storage disease, which may benefit from treatment approaches that target the handling of misfolded proteins.

  4. Deletion of Lamb2 and Lamc3 (show LAMC3 Proteins) genes affects astrocyte migration and spatial patterning in the retina.

  5. These results suggest the possibility that up-regulation of LAMB1 (show LAMB1 Proteins) in podocytes, should it become achievable, would likely lessen the severity of nephrotic syndrome in patients carrying LAMB2 mutations.

  6. a strong impact of laminin beta2 and gamma3 subunits on the expression and function of both aquaporin-4 (show AQP4 Proteins) and Kir4.1 (show KCNJ10 Proteins), two important membrane proteins in Muller cells.

  7. Glomerular basement protein permeability to the electron-dense tracer ferritin (show FTL Proteins) is dramatically elevated in Lamb2 deficient mice.

Human Laminin, beta 2 (Laminin S) (LAMB2) interaction partners

  1. In conclusion, we reported three Chinese cases with different LAMB2 mutations and different phenotypes, further broadening the range of eye and kidney pathology associated with mutations in LAMB2.

  2. Laminins 411 and 421 differentially promote tumor cell migration via alpha6beta1 integrin and MCAM (CD146 (show MCAM Proteins)).

  3. No pathogenic LAMB2 mutations were found in the cohort of children with steroid-resistant focal segmental glomerulosclerosis.

  4. Comprehensive gene sequencing revealed a novel LAMB2 variant (c.440A --> G; His147R) that was homozygous in the 9 living, affected family members, observed at a frequency of 2.1% in the Old Order Mennonite population, and absent in 91 non-Mennonite controls

  5. Novel mutations in steroid-resistant nephrotic syndrome diagnosed in Tunisian children were detected in LAMB2.

  6. All previously reported and several novel LAMB2 mutations in relation to the associated phenotype in patients from 39 unrelated families, are reviewed.

  7. Laminin-10/11 and fibronectin (show FN1 Proteins) differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt (show AKT1 Proteins)- and MEK1 (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins)-dependent pathways (Laminin 10; separate entry for Laminin 11).

  8. Deficiency in LAMB2 causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities.

  9. Hepalaminin, an autoantigen from chronic hepatitis C, consists of two domains of laminin beta-2 and a specific domain.

  10. Mutations in the LAMB2 gene encoding laminin beta2, a component of the glomerular basement membrane and the neuro-muscular junction are responsible for the characteristic renal and eye abnormalities of Pierson syndrome.

LAMB2 Protein Profile

Protein Summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known.

Alternative names and synonyms associated with LAMB2

  • laminin, beta 2 (laminin S) (LAMB2)
  • laminin beta 2 (LAMB2)
  • laminin, beta 2 (Lamb2)
  • laminin, beta 2 (laminin S) (Lamb2)
  • AW211941 protein
  • Lamb-2 protein
  • LAMC1 protein
  • laminin protein
  • LAMS protein
  • NPHS5 protein
  • SLAM protein

Protein level used designations for LAMB2

laminin subunit beta-2 , S-LAM beta , S-laminin subunit beta , laminin chain B3 , laminin chain beta 2 , laminin-11 subunit beta , laminin-14 subunit beta , laminin-15 subunit beta , laminin-3 subunit beta , laminin-4 subunit beta , laminin-7 subunit beta , laminin-9 subunit beta , Laminin S , gamma 1 (formerly LAMB2) , laminin, gamma 1 (formerly LAMB2) , laminin B1s chain , laminin S

520167 Bos taurus
101101688 Sus scrofa
25473 Rattus norvegicus
16779 Mus musculus
373980 Gallus gallus
3913 Homo sapiens
100732418 Cavia porcellus
476626 Canis lupus familiaris
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