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we report a family with a null mutation in GATA2 and Emberger syndrome with variable expressivity and incomplete penetrance. This case emphasizes the need of genetic interactions to produce specific phenotypes in the clinical spectrum of GATA2 deficiency, where no precise genotype-phenotype correlation has been found.
Studied GATA2 Deficiency With Severe Primary Epstein-Barr Virus (EBV) Infection and EBV-associated Cancers. Seven patients with GATA2 deficiency developed severe EBV disease. Also found GATA2 to be the first gene associated with EBV hydroa vacciniforme-like lymphoma.
GATA2 deficiency is associated with impaired membrane expression and chemotactic dysfunctions of CXCR4 (show CXCR4 ELISA Kits).
decline of GATA2 resulting from mutations contributes to the erythroid commitment, differentiation and the development of AEL
the distinct mechanisms by which GATA2 and FOXA1 (show FOXA1 ELISA Kits) regulate AR cistrome and suggest that FOXA1 (show FOXA1 ELISA Kits) acts upstream of GATA2 and AR in determining hormone-dependent gene expression in prostate cancer.
adaptive NK cells can persist in patients with GATA2 mutation, even after NK-cell progenitors expire.
reducing GATA2 expression or inhibition of its transcription activity can relieve the drug resistance of acute myeloid leukemia (show BCL11A ELISA Kits) cells and it would be helpful for eliminating the leukemia cells in patients
we suggest screening for GATA2 mutations in pediatric myelodysplastic syndrome, preferentially in patients with impaired B-cell homeostasis in bone marrow and peripheral blood (low number of progenitors, intronRSS-Kde recombination excision circles and naive cells.
Knockdown of GATA-2 caused NGB (show GTPBP4 ELISA Kits) expression to drop dramatically, indicating GATA-2 as an essential transcription factor for the activation of NGB (show GTPBP4 ELISA Kits) expression via binding to a novel distal regulatory element of NGB (show GTPBP4 ELISA Kits).
we demonstrated that miR (show MLXIP ELISA Kits)-22 promoted monocyte/macrophage differentiation, and MECOM (EVI1 (show MECOM ELISA Kits)) mRNA is a direct target of miR (show MLXIP ELISA Kits)-22 and MECOM (EVI1 (show MECOM ELISA Kits)) functions as a negative regulator in the differentiation.The miR (show MLXIP ELISA Kits)-22-mediated MECOM (show MECOM ELISA Kits) degradation increased c-Jun (show JUN ELISA Kits) but decreased GATA2 expression, which results in increased interaction between c-Jun (show JUN ELISA Kits) and PU.1
bcar3 gene is expressed downstream of Gata2 during gastrulation, and is co-expressed with gata2 but is more broadly expressed during later development; its binding partner, bcar1 (show BCAR1 ELISA Kits) shows overlapping expression patterns
results are consistent with a model in which GATA2 contributes to inhibition of canonical Wnt (show WNT2 ELISA Kits) signaling
these findings, strongly implicate Dlx3 in the regulation of non-neural competence, and show that GATA2 contributes to non-neural competence but is not sufficient to promote it ectopically.
Studies suggest a two-component model for the binding of CBTF (show MMP4 ELISA Kits) with gata2 promoter, requiring both a CCAAT and A-form DNA, and the double stranded RNA binding domains (dsRBDs) of CBTF (show MMP4 ELISA Kits) component Xilf3 (show MMP4 ELISA Kits) must be active for both binding to the promoter.
Gata-2 is a transcriptional target downstream of BMPs within ectodermal cells, while activation of the CaM KIV signaling pathway alters GATA-2 function posttranslationally, by inhibiting its acetylation.
GATA2 and/or GATA3 (show GATA3 ELISA Kits) are involved in the regulation of trophoblast-specific gene transcription in bovine trophoblast CT-1 (show SLC6A8 ELISA Kits) cells
Gata2 mRNA levels were almost completely rescued by expression of an erythroid lineage restricted ROSA26-promotor based GATA2 transgene
Gata2 heterozygous deletion confers selective advantage to EVI1 (show MECOM ELISA Kits)-expressing leukemia cell expansion in recipient mice
impairment of trophoblast-specific GATA2/GATA3 (show GATA3 ELISA Kits) function could lead to early pregnancy failure
both Gata2 and Gata3 (show GATA3 ELISA Kits) are redundantly required for differentiation of the serotonergic and glutamatergic neurons of the dorsal raphe
Dynamically and epigenetically coordinated GATA2/ETS1SOX7 transcription factor expression is indispensable for endothelial cell differentiation.
High GATA2 expression is associated with leukemia.
results suggest that GATA2 plays an important role in cell-fate specification toward the myeloid vs T-lymphocyte lineage by regulating lineage-specific transcription factors in DC progenitors, thereby contributing to DC differentiation.
These results demonstrated that an enforced expression of Gata2 in late HECs of differentiated ESCs (show NR2E3 ELISA Kits) efficiently promotes megakaryopoiesis followed by platelet production. This study provides valuable information for ex vivo platelet production from human pluripotent stem cells in future.
we identified important roles for the GATA-2 C-ZnF in bone marrow hematopoiesis via control of c-Kit expression and HSC/HSPC survival.
Data show that transforming growth factor beta (TGFbeta (show TGFB1 ELISA Kits))-induced changes in Gata2 transcription factor and cyclin-dependent kinase inhibitor 1C (P57 (show CDKN1C ELISA Kits)) expression in hematopoietic progenitors are conveyed through Smad (show SMAD1 ELISA Kits) signaling via Smad4 protein (show SMAD4 ELISA Kits).
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.
GATA binding protein 2
, glutamyl/aspartyl-tRNA(Gln/Asp) amidotransferasesubunit A
, hypothetical protein
, protein GatA2
, GATA2 transcription factor
, endothelial transcription factor GATA-2-like
, endothelial transcription factor GATA-2
, GATA binding factor-2
, GATA-binding factor 2
, transcription factor xGATA-2
, transcription factor NF-E1B
, transcription factor GATA-2
, GATA-binding protein 2
, GATA-bindning protein 2