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show specific evidence for a cell-autonomous requirement for Msi family proteins in regulating stem cell differentiation, leading to the identification of an RNA-binding protein required for spermatogonial stem cell maintenance
Msi1promoted epithelial-mesenchymal transformation of cervical neoplasms via activation of the Wnt (show WNT2 ELISA Kits) signaling pathway and contributing to poor prognosis.
our results suggest a role for MSI1 in double-strand break repair and that its inhibition may enhance the effect of radiotherapy
Results show that Meis1 (show MEIS1 ELISA Kits) may have a positive feedback with Msi1 during the esophageal squamous cell carcinoma progression.
Musashi-1 expression was higher in Barrett esophagus and early esophageal adenocarcinoma compared to advanced adenocarcinoma.
miR (show MLXIP ELISA Kits)-761 and MSI1 are inversely expressed in ovarian cancer tissues. In conclusion, we demonstrated that miR (show MLXIP ELISA Kits)-761 repressed ovarian cancer proliferation and invasion by targeting MSI1
Concomitant loss of function of both MSI1 is sufficient to abrogate the growth of human colorectal cancer cells, and Msi gene deletion inhibits tumorigenesis in several mouse models of intestinal cancer.
Msi1 overexpression is associated with Esophageal Squamous Cell Carcinoma.
studies highlight Msi reporters as a unique tool to identify therapy resistance, and define Msi signalling as a central regulator of pancreatic cancer
Musashi-1 and ALDH1 (show ALDH1A1 ELISA Kits) expression are closely related to metastasis of ovarian adenocarcinoma.
Suggest high level of Musashi-1 protein expression is associated with poor survival in endometrioid adenocarcinoma patients.
Msi (show EBP ELISA Kits) proteins are dispensable for normal homeostasis and self-renewal of the active intestinal stem cell.
photoreceptors lack prototypical neuronal splicing factors and their splicing profile is driven to a significant degree by the Musashi 1 (MSI1) protein. A striking feature of the photoreceptor splicing program are exons that display a "switch-like" pattern of high inclusion levels in photoreceptors and near complete exclusion outside of the retina.
Given that deregulated fatty acid metabolism plays a key role in kidney fibrosis, these results demonstrate a novel connection between fatty acid and Msi1, an RNA-binding protein, in kidney fibrosis
A Mouse Model of Targeted Musashi1 Expression in Whole Intestinal Epithelium Suggests Regulatory Roles in Cell Cycle and Stemness.
studies highlight Msi (show EBP ELISA Kits) reporters as a unique tool to identify therapy resistance, and define Msi (show EBP ELISA Kits) signalling as a central regulator of pancreatic cancer
the RNA-binding protein Musashi 1 competes with miR130a and -206 for interaction with tachykinin mRNA
MSI1 and MSI2 (show MSI2 ELISA Kits) display distinct expression profiles during mammalian folliculogenesis and that MSI2 (show MSI2 ELISA Kits) is required for pre-antral follicle development
Osteoarticular expression of Msi1 protein is increased in joints with CIA (show NCOA5 ELISA Kits)-induced lesion and absent in nonlesioned joints, suggesting that this protein is expressed when the lesion is produced in order to favor tissue repair.
Msi1 is critical for constructing functional blood-testis barrier &maintaining spermatogenesis. Msi1 regulates Sertoli cell fate following heat-induced injury, likely through induction of stress granule formation & activation of p-ERK1/2 (show MAPK1/3 ELISA Kits) signaling
Through expression studies and utilizing a transgenic Msi1 testis-specific (show AIF1 ELISA Kits) overexpression model, we have identified 2 unique RNA-binding targets of MSI1 in spermatogonia, Msi2 (show MSI2 ELISA Kits) and Erh (show ERH ELISA Kits), and have demonstrated a role for MSI1 in translational regulation.
Genome-wide analysis of CPEB1- and Msi1-associated mRNAs identified 491 common targets, thus revealing a new layer of cytoplasmic polyadenylation elements-mediated translational control.
specific association of Musashi with the noncanonical poly(A) polymerase (show PAPOLA ELISA Kits) germ line development defective-2 (GLD2 (show PAPD4 ELISA Kits))
Xenopus Musashi proteins regulate translation of the Musashi1 mRNA during oocyte maturation.
Ringo/cyclin-dependent kinase (show CDK1 ELISA Kits) and mitogen-activated protein kinase (show MAPK1 ELISA Kits) signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes.
These findings indicate that Musashi function is necessary to establish the temporal order of maternal mRNA translation during Xenopus meiotic cell cycle progression.
Msi-1 expression is upregulated in the adult progenitor cells and plays important roles in their maintenance and/or active proliferation during amphibian gastrointestinal remodeling.
Visual deprivation for 2 days increased proliferation of musashi1-immunoreactive radial glial progenitors
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13.
, musashi homolog 1
, Musashi 1
, musashi 1
, RNA-binding protein Musashi homolog 1
, RNA-binding protein Musashi-1
, Musashi homolog 1(Drosophila)