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Human Polyclonal PCM1 Primary Antibody for ICC, IF - ABIN4344087
Gilsbach, Preissl, Grüning, Schnick, Burger, Benes, Würch, Bönisch, Günther, Backofen, Fleischmann, Schübeler, Hein: Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease. in Nature communications 2014
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Human Polyclonal PCM1 Primary Antibody for ICC, IF - ABIN4344089
Bergmann, Zdunek, Alkass, Druid, Bernard, Frisén: Identification of cardiomyocyte nuclei and assessment of ploidy for the analysis of cell turnover. in Experimental cell research 2010
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Human Polyclonal PCM1 Primary Antibody for IP, WB - ABIN188819
Kuriyama, Bettencourt-Dias, Hoffmann, Arnold, Sandvig: Gamma-tubulin-containing abnormal centrioles are induced by insufficient Plk4 in human HCT116 colorectal cancer cells. in Journal of cell science 2009
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Human Polyclonal PCM1 Primary Antibody for FACS, IF - ABIN391696
Fang, Zhang, Yin, Zheng, Bi, Yuan: Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion. in Journal of cell science 2014
Human Polyclonal PCM1 Primary Antibody for WB - ABIN518687
Akimov, Rigbolt, Nielsen, Blagoev: Characterization of ubiquitination dependent dynamics in growth factor receptor signaling by quantitative proteomics. in Molecular bioSystems 2011
In the absence of PCM1, Mib1 destabilizes Talpid3 through poly-ubiquitylation and suppresses cilium assembly.
Data suggest that USP9X as an integral component of centrosome where it functions to stabilize PCM1 and CEP55 and to promote centrosome biogenesis; N-terminal domain of USP9X appears to be responsible for physical association of USP9X with PCM1 and CEP55. (USP9X = ubiquitin-specific protease 9X; PCM1 = pericentriolar material 1 protein; CEP55 = 55kDa centrosomal protein)
a novel variant in the PCM1 (show MBD1 Antibodies) 3'UTR (show UTS2R Antibodies) is significantly associated with ovarian cancer
no association between the PCM1 (show MBD1 Antibodies) gene and schizophrenia in a Japanese population
Haematological neoplasms associated with t(8;9)(p22 (show DYNC1H1 Antibodies);p24); PCM1 (show MBD1 Antibodies)-JAK2 (show JAK2 Antibodies) have features in common and we suggest that they should be recognized as a specific entity in the WHO classification
these data suggest a mechanism whereby the recruitment of Plk1 (show PLK1 Antibodies) to pericentriolar matrix by PCM1 (show MBD1 Antibodies) plays a pivotal role in the regulation of primary cilia disassembly before mitotic entry.
Chromosomal translocation [t(8;9)(p22 (show DYNC1H1 Antibodies);p24)]/PCM1 (show MBD1 Antibodies)-JAK2 (show JAK2 Antibodies) fusion protein activates SOCS2 (show SOCS2 Antibodies) and SOCS3 (show SOCS3 Antibodies) via STAT5 (show STAT5A Antibodies) in a cutaneous T-cell lymphoma cell line.
CEP90 physically interacts with PCM-1 at centriolar satellites, and this interaction is essential for centrosomal accumulation of the centriolar satellites and eventually for primary cilia formation.
PCM1 (show MBD1 Antibodies) interacts with Hook2 (show HOOK2 Antibodies) in a complex that regulates a limiting step required for further initiation of ciliogenesis after centriole maturation.
NEK7 (show NEK7 Antibodies) is essential for PCM (show PCMT1 Antibodies) accumulation in a cell cycle stage-specific manner.
MicroRNA (miR (show MLXIP Antibodies))-128 regulates the proliferation and differentiation of neural progenitor cells by repressing pericentriolar material 1 (PCM1).
haploinsufficiency at the Pcm1 (show MBD1 Antibodies) locus can induce a range of neuroanatomical and behavioral phenotypes that support the candidacy of this locus in neuropsychiatric disorders.
deletion of Htt (show HTT Antibodies) in ependymal cells led to PCM1 (show MBD1 Antibodies) mislocalization, alteration of the cilia layer, and hydrocephalus
results identify a novel role for PCM- 1 (show MBD1 Antibodies) in cell cycle regulation, and indicate that PCM-1 (show MBD1 Antibodies) must fulfill an essential function for cells to complete interphase
Pcm1 (show MBD1 Antibodies) colocalized with centrosomal components in cytoplasmic granules surrounding nascent centrioles. Interfering with Pcm1 (show MBD1 Antibodies) reduced the amount of centrosomal proteins at basal bodies but did not prevent centriole assembly.
The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma.
pericentriolar material 1
, pericentriolar material 1 protein-like
, Pericentriolar material 1 protein-like
, pericentriolar material 1 protein
, pericentriolar material 1, PCM1
, pericentriolar material gene 1
, pericentriolar material-1