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PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response.
study achieved a long-lasting expression of Prox1 in lymphatic endothelial-like cells, and it provided a potentially useful approach for developing novel therapies for limb lymphedema and lymphatic system-related diseases
In gastric cancer, high cytoplasmic PROX1 expression is an independent marker of better prognosis.
High PROX1 and beta-catenin (show CTNNB1 Proteins) expression were independent factors for better prognosis in pancreatic ductal adenocarcinoma.
Data suggest that DBC1 has a dual function in regulating beta-catenin (show CTNNB1 Proteins)-PROX1 signaling axis: as a coactivator for both beta-catenin (show CTNNB1 Proteins) and PROX1.
PROX1 gene is a strong candidate of early onset of diabetes with variations depending on ethnicity.
We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 (show SLC12A2 Proteins) rs17764730, PSMB5 (show PSMB5 Proteins) rs941718), and hematocrit (PROX1 rs3754140) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant
PROX1 serves an oncogenic role in glioblastoma multiforme and promotes cell proliferation and invasiveness potentially via activation of the NFkappa B signaling pathway.
High PROX1 expression is associated with gastric cancer.
High PROX1 expression is associated with Esophageal Squamous Cell Carcinoma.
Our study demonstrates that Prox1 (show C16orf35 Proteins)-GFP/Flk1 (show KDR Proteins)::myr-mCherry mice are a useful model for studying coordinated hemangiogenic and lymphangiogenic responses
Prox1 (show C16orf35 Proteins) was first expressed in all developing neurons, followed by a decrease in type II primary auditory neurons as they matured.
Data indicate that prospero-related homeobox 1 (Prox1) has a role in regulating energy homeostasis in hepatocytes.
These results are the first demonstration that Prox1 (show C16orf35 Proteins) activity protects pancreatic cells from acute tissue damage and early neoplastic transformation. Additional data in our study indicate that this novel role of Prox1 (show C16orf35 Proteins) involves suppression of pathways associated with inflammatory responses and cell invasiveness.
the data show that Prox1 (show C16orf35 Proteins) regulates proliferation and differentiation of the oligodendrocyte cell lineage, and is a relevant component of the endogenous regenerative response to Central nervous system injury.
Prox1 (show C16orf35 Proteins) upregulation reduces proliferation, impairs maturation, and enables apoptosis in postnatal beta-cells. Prox1 (show C16orf35 Proteins) overexpression causes MafA (show MAFA Proteins) deficiency in beta-cells.
The PROX1 (show C16orf35 Proteins)-mediated repression is weakened or lost, thereby facilitating the induction of Reverse cholesterol transport genes and diminishing the progression of atherosclerosis
suggest that Prox1 (show C16orf35 Proteins) appears to be a critical stage specific regulator of specifying ascending thin limb cell fate and that its expression is regulated by osmolality
we demonstrate that Prox1 (show C16orf35 Proteins) and Asap1 (show ASAP1 Proteins) behave as negative regulators of mammary stem/progenitor function. Both of these genes have also been implicated in oncogenesis.
using a transgenic reporter line, we show that prox1a is initially expressed in different endothelial compartments, becoming restricted to lymphatic endothelial cells only at later stages
Functional analysis using antisense morpholinos indicates that prox1 activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts.
Prox1 functions as a tissue-specific coregulator of Ff1b
Our findings indicate that prox1 activity is crucial for the proper development of the otp1 (show OTOP1 Proteins)-positive hypothalamic neuronal precursors to their terminal CA phenotype
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants.
prospero homeobox 1
, prospero homeobox protein 1-like
, Prox 1
, prospero-related homeobox 1
, homeobox prospero-like protein PROX1
, prospero homeobox protein 1
, prospero-related homeobox gene 1