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Genome-wide analysis indicated that LMO2 (show LMO2 Proteins) is required at the hemangioblast stage to position the TAL1/LMO2 (show LMO2 Proteins)/LDB1 (show LDB1 Proteins) complex to regulatory elements that are important for the establishment of the hematopoietic developmental program.
TAL1 and GATA1 (show GATA1 Proteins) form a precisely organized complex at a compound motif consisting of a TG 7 or 8 bp upstream of a WGATAA motif across thousands of genomic locations
SCL-LMO1 (show LMO1 Proteins) upregulated a stem cell gene signature in DN3 thymocytes.
TAL1 binds specifically to many genomic locations in multilineage precursor and erythroid progenitor cells, before GATA1 (show GATA1 Proteins) is produced abundantly.
Ectopic Runx1 (show RUNX1 Proteins) expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.
Tal1 has a role in severe renal disease and patchy alopecia in Hairpatches (Hpt) mice
Only Scl but not Map17 (show PDZK1IP1 Proteins) could rescue the Scl(Delta40/Delta40) ES phenotype.
Scl overexpression is sufficient to rescue the developmental defects caused by blocking the Hh and Notch (show NOTCH1 Proteins) pathways during the embryonic endothelial-to-hematopoietic transition.
a novel role for GATA-4 (show GATA4 Proteins) and TAL1 to affect skeletal myogenic differentiation and EPO (show EPO Proteins) response via cross-talk with Sirt1 (show SIRT1 Proteins).
Studies revealed an unexpected repressive role for Scl, as loss of Scl resulted in the generation of ectopic cardiomyocytes in yolk sac (show ADCY10 Proteins) vasculature and the endocardium; these results uncover remarkable developmental plasticity in embryonic vasculature and identify Scl as a key determinant of endothelial fate choice.
NF-E2, TAL1 and KLF1, all activators play a primary role in HSs formation in the LCR
mutations of SF3B1 (show SF3B2 Proteins) may block erythropoiesis via dysregulation of alternative RNA splicing of transcription factor TAL1
a novel role of FOXP3 (show FOXP3 Proteins) as a tumor suppressor in T-ALL through modulation of TAL1 transcriptional activity.
Review emphasizes recent findings that shed light into the intricacies of TAL1 (epi (show TFPI Proteins))genetic regulation and the transcription network orchestrated by this major T-cell oncogene (show RAB1A Proteins).[reiew]
Deletions of TAL1 is associated with acute T-lymphoblastic leukemia.
SCL/TAL1 (stem cell leukemia/T-cell acute lymphoblastic leukemia [T-ALL] 1) is an essential transcription factor in normal and malignant hematopoiesis.
Upregulation of TAL1 is associated with T-cell acute lymphoblastic leukemia.
Concurrent exogenous expression of three transcription factors, GATA1 (show GATA1 Proteins), FLI1 (show FLI1 Proteins) and TAL1, enables large-scale production of megakaryocytes from human pluripotent stem cells.
analysis of a point mutation that increases fetal globin expression through de novo recruitment of the activator TAL1 to promote chromatin looping of distal enhancers to the modified gamma-globin promoter
a successful induction of gamma-globin (show HBG1 Proteins) includes a reduction in BCL11A (show BCL11A Proteins), KLF1 (show KLF1 Proteins) and TAL1 expression.
The latter data suggest that Stil play a role in retina cell proliferation through the Shh (show SHH Proteins) signal transduction pathway.
Tal1 has distinct roles in regulating the formation of endocardial intercellular junctions.
Data suggest that a defined hemogenic endothelial population preset by scl-beta supports the deterministic emergence of HSCs, and unravel the cellular mechanisms by which scl isoforms regulate HSC (show FUT1 Proteins) development.
Our studies establish a new connection between RA and scl during development that may participate in stem cell self-renewal and hematopoietic differentiation
Ets1-related protein (show ETV2 Proteins) plays a critical role in the initiation of definitive hematopoiesis by controlling the expression of 2 stem cell leukemia (scl) isoforms (scl-alpha and scl-beta) in angioblasts.
in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2 (show LMO2 Proteins)-induced haemangioblasts differentiate into endothelial cells
Zebrafish scl has a role in hematopoietic and endothelial development, downstream of hemangioblast development.
scl is especially critical for the development of arteries where adult hematopoietic stem cells emerge, implicating scl in the formation of hemogenic endothelium
Scl participates in multiple processes requiring different levels and functions
While scl-alpha and -beta are redundant for the initiation of primitive hematopoiesis, these two isoforms exert distinct functions in the regulation of primitive erythroid differentiation and definitive hematopoietic stem cell specification.
Transcription factor that acts synergistically with lmo2 and gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate.
T-cell acute lymphocytic leukemia 1
, T-cell acute lymphocytic leukemia protein 1 homolog
, stem cell protein
, T-cell acute lymphocytic leukemia protein 1
, T-cell leukemia/lymphoma protein 5
, class A basic helix-loop-helix protein 17
, tal-1 product
, stem cell leukaemia
, stem cell leukemia protein SCL
, Avian SCL
, stem-cell leukemia hematopoietic transcription factor
, transcription factor