Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human TET1 Antibodies:
anti-Mouse (Murine) TET1 Antibodies:
anti-Rat (Rattus) TET1 Antibodies:
Go to our pre-filtered search.
Human Polyclonal TET1 Primary Antibody for ChIPSeq, ChIP - ABIN2668522
Feng, Wang, Li, Zeng, Kuang, Li, Yue: TET1-mediated different transcriptional regulation in prostate cancer. in International journal of clinical and experimental medicine 2015
Show all 2 Pubmed References
Mouse (Murine) Monoclonal TET1 Primary Antibody for ICC, IF - ABIN5563987
Bauer, Göbel, Nagaraj, Colantuoni, Wang, Müller, Kremmer, Rottach, Leonhardt: Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT). in The Journal of biological chemistry 2015
Show all 2 Pubmed References
Human Polyclonal TET1 Primary Antibody for ICC, IF - ABIN4358581
Zhao, Zhang, Xia, Zhou, Cao: Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells. in Oncology letters 2015
TET1 potently inhibited canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling by demethylating and upregulating two upstream antagonists of this pathway, SFRP2 (show SFRP2 Antibodies) and DKK1 (show DKK1 Antibodies), which was associated with inhibition of EMT (show ITK Antibodies) and cancer cell metastasis.
Data suggest that the predominantly activated isoform of tet oncogene 1 protein (TET1) in cancer cells does not protect from unmethylated CpG islands (CGIs) methylation and likely mediates dynamic site-specific demethylation outside of CGIs.
MBD1 (show DPEP1 Antibodies) regulates localization and activity of Tet1 in a CXXC3 (show MBD1 Antibodies) domain-dependent manner.
Because the DNA hypomethylation might be a result of TET dioxygenase activity, the study examined expression of TET1-3 enzymes and the level of their product, 5-hydroxymethylcytosine (5hmC), in a panel of histologically characterized seminomas and non-seminomatous germ cell tumors. The study found highly increased expression of TET1 dioxygenase in most seminomas and strong TET1 staining in seminoma cells.
Compared to normal tissues, the expression level of TET1 in colorectal cancer (CRC (show CALR Antibodies)) was significantly lower. Moreover, in vitro studies showed that TET1 could inhibit cell growth and promote cell metastasis and invasion.TET1 played a multifaceted role in the pathogenesis of CRC (show CALR Antibodies), and thereby resulting in multiple effects on tumor progression.
In this study, we show that hypercholesterolemia increases the incidence and pathologic severity of colorectal neoplasia in two independent mouse models. Hypocholesterolemia induced an oxidant stress-dependent increase in miR101c, which downregulated Tet1 in hematopoietic stem cells (HSC (show FUT1 Antibodies)), resulting in reduced expression of genes critical to natural killer T cell (NKT (show SLC22A6 Antibodies)) and gamma delta T-cell differentiation
miR (show MLXIP Antibodies)-29b targets the DNA-demethylating enzyme, TET1, for downregulation resulting in decreased 5-hmC epigenetic modifications.
The results of the present study demonstrate that TET1 might function as one of the key molecules in SOD3 (show SOD3 Antibodies) expression through its 5mC hydroxylation in A549 cells.
Results show that the levels of TET1 transcript are elevated in medulloblastoma and ependymoma cells may imply that this protein is involved in pathogenesis of the paediatric brain tumours via demethylation of the regulatory elements of the oncogenes promoting initiation and/or progression of these types of cancer.
Loss of TET1 may induce aberrant DNA methylation (show HELLS Antibodies) and may attenuate the effect of 5-aza-2'-deoxycytidine in colorectal cancer cells.
TET1 regulates numerous genes defining differentiation programs in the epiblast and extraembryonic ectoderm. In epiblasts, TET1 demethylates gene promoters via hydroxymethylation and maintains telomere stability. It represses a majority of epiblast target genes independent of methylation, partly by regulation of the JMJD8 gene. Dysregulated gene expression in the absence of TET1 causes embryonic defects.
Isoform switch of TET1 regulates DNA demethylation and mouse development.
Low TET1 expression is associated with Liver Cancer.
Zfp281 (show ZNF281 Antibodies) interacts with Tet1, but not Tet2 (show TET2 Antibodies), and its direct transcriptional target, miR (show MLXIP Antibodies)-302/367, to negatively regulate Tet2 (show TET2 Antibodies) expression to establish and maintain primed pluripotency.
Our data implicate TET enzymes ( TET1 and TET2 (show TET2 Antibodies) )in the evolutionary dynamics of TEs (show TES Antibodies), both in the context of exaptation processes and of retrotransposition control. The dual role of TET action on LINE-1s may reflect the evolutionary battle between TEs (show TES Antibodies) and the host
our findings reveal that TET1 forms a complex with hMOF (show KAT8 Antibodies) to modulate its function and the level of H4K16Ac ultimately affect gene expression and DNA repair.
a complex relationship between ten-eleven translocation (TET) proteins and retrotransposons in mouse embryonic stem cells (ESCs (show NR2E3 Antibodies)), implicating TETs as enhancers in the exaptation and function of retroelement sequences.
Tet1-mediated DNA hydroxymethylation plays a critical role in the epigenetic regulation of the Wnt (show WNT2 Antibodies) pathway in intestinal stem and progenitor cells and consequently in the self-renewal of the intestinal epithelium.
The current Tet1 RefSeq mRNA sequences (NM_001253857.1 and NM_027384.1) start with the coding sequence and lack the 5'UTR (show UTS2R Antibodies). We describe in this paper two previously unannotated alternative 5'UTR (show UTS2R Antibodies) exons in the gene Tet1. Transcripts initiated from exon 1b are expressed highly in mouse embryonic stem cells, whereas those initiated from exon 1a are constitutively expressed at low levels in adult tissues.
TET3 (show TET3 Antibodies) dioxygenase was present in the very first embryo stages, in contrast to TET1 and AICDA (show AICDA Antibodies).
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5- hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification.
CXXC finger 6
, CXXC zinc finger 6
, CXXC-type zinc finger protein 6
, leukemia-associated protein with a CXXC domain
, methylcytosine dioxygenase TET1
, ten-eleven translocation 1 gene protein
, ten-eleven translocation-1
, tet oncogene 1
, ten-eleven translocation 1 gene protein homolog
, tet methylcytosine dioxygenase 1