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anti-Human TET1 Antibodies:
anti-Mouse (Murine) TET1 Antibodies:
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Mouse (Murine) Monoclonal TET1 Primary Antibody for ICC, IF - ABIN5563987
Bauer, Göbel, Nagaraj, Colantuoni, Wang, Müller, Kremmer, Rottach, Leonhardt: Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT). in The Journal of biological chemistry 2015
Show all 2 Pubmed References
Human Polyclonal TET1 Primary Antibody for ChIPSeq, ChIP - ABIN2668522
Feng, Wang, Li, Zeng, Kuang, Li, Yue: TET1-mediated different transcriptional regulation in prostate cancer. in International journal of clinical and experimental medicine 2015
Show all 2 Pubmed References
Human Polyclonal TET1 Primary Antibody for ICC, IF - ABIN4358581
Zhao, Zhang, Xia, Zhou, Cao: Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells. in Oncology letters 2015
Data show that ten-eleven translocation 1 (TET1) suppresses tumor cell growth, migration and invasion through demethylation of CpG island in PTEN (show PTEN Antibodies) promoter by increasing 5-hmC content.
Therefore, chemical hypoxia not only causes overexpression of TET1 and TET2 (show TET2 Antibodies) but also could gradually do promoter demethylation of same genes
Overexpression of the wild-type TET1/2/3 3'UTR (show UTS2R Antibodies) caused a significant increase in EZH2 (show EZH2 Antibodies) expression and tumor growth, whereas the mutation in miR (show MLXIP Antibodies)-26-binding sites abolished this effect.
Data show that low TET1 mRNA levels were significantly associated with worse metastases-free survival.
TET1 binds to tumor suppressor promoters and induces their re-expression through active DNA demethylation.
Loss of TET1 expression facilitates colon cancer cell migration via H3K27me3-mediated repression of E-cadherin (show CDH1 Antibodies) expression.
TET1 potently inhibited canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling by demethylating and upregulating two upstream antagonists of this pathway, SFRP2 (show SFRP2 Antibodies) and DKK1 (show DKK1 Antibodies), which was associated with inhibition of EMT (show ITK Antibodies) and cancer cell metastasis.
Data suggest that the predominantly activated isoform of tet oncogene 1 protein (TET1) in cancer cells does not protect from unmethylated CpG islands (CGIs) methylation and likely mediates dynamic site-specific demethylation outside of CGIs.
MBD1 (show DPEP1 Antibodies) regulates localization and activity of Tet1 in a CXXC3 (show MBD1 Antibodies) domain-dependent manner.
Because the DNA hypomethylation might be a result of TET dioxygenase activity, the study examined expression of TET1-3 enzymes and the level of their product, 5-hydroxymethylcytosine (5hmC), in a panel of histologically characterized seminomas and non-seminomatous germ cell tumors. The study found highly increased expression of TET1 dioxygenase in most seminomas and strong TET1 staining in seminoma cells.
that Tet1 modulates HIF-2alpha (show EPAS1 Antibodies) and HIF-1alpha (show HIF1A Antibodies) through different mechanisms.
TET1 is an epigenetic determinant for regulating genes that are crucial to closure of the anterior neural tube.
TET1 regulates numerous genes defining differentiation programs in the epiblast and extraembryonic ectoderm. In epiblasts, TET1 demethylates gene promoters via hydroxymethylation and maintains telomere stability. It represses a majority of epiblast target genes independent of methylation, partly by regulation of the JMJD8 gene. Dysregulated gene expression in the absence of TET1 causes embryonic defects.
Isoform switch of TET1 regulates DNA demethylation and mouse development.
Low TET1 expression is associated with Liver Cancer.
Zfp281 (show ZNF281 Antibodies) interacts with Tet1, but not Tet2 (show TET2 Antibodies), and its direct transcriptional target, miR (show MLXIP Antibodies)-302/367, to negatively regulate Tet2 (show TET2 Antibodies) expression to establish and maintain primed pluripotency.
Our data implicate TET enzymes ( TET1 and TET2 (show TET2 Antibodies) )in the evolutionary dynamics of TEs (show TES Antibodies), both in the context of exaptation processes and of retrotransposition control. The dual role of TET action on LINE-1s may reflect the evolutionary battle between TEs (show TES Antibodies) and the host
our findings reveal that TET1 forms a complex with hMOF (show KAT8 Antibodies) to modulate its function and the level of H4K16Ac ultimately affect gene expression and DNA repair.
a complex relationship between ten-eleven translocation (TET) proteins and retrotransposons in mouse embryonic stem cells (ESCs (show NR2E3 Antibodies)), implicating TETs as enhancers in the exaptation and function of retroelement sequences.
TET3 (show TET3 Antibodies) dioxygenase was present in the very first embryo stages, in contrast to TET1 and AICDA (show AICDA Antibodies).
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5- hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification.
CXXC finger 6
, CXXC zinc finger 6
, CXXC-type zinc finger protein 6
, leukemia-associated protein with a CXXC domain
, methylcytosine dioxygenase TET1
, ten-eleven translocation 1 gene protein
, ten-eleven translocation-1
, tet oncogene 1
, ten-eleven translocation 1 gene protein homolog
, tet methylcytosine dioxygenase 1