Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human TET1 Antibodies:
anti-Mouse (Murine) TET1 Antibodies:
anti-Rat (Rattus) TET1 Antibodies:
Go to our pre-filtered search.
Human Polyclonal TET1 Primary Antibody for ICC, IF - ABIN4358581
Zhao, Zhang, Xia, Zhou, Cao: Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells. in Oncology letters 2015
that miR (show MLXIP Antibodies)-30a could inhibit TET1 expression through base pairing with complementary sites in the 3'untranslated region to regulate Drp-1 (show CRMP1 Antibodies) promoter hydroxymethylation.
We found that TET1 and TET2 (show TET2 Antibodies) messenger RNA expression was lower and TET3 (show TET3 Antibodies) was higher in cancers compared to normal tissues. Positive correlation between 5-hmC and the relative expression of TET1 and TET2 (show TET2 Antibodies) was found, but no correlation was observed in the case of TET3 (show TET3 Antibodies).
Increased TET1 induced re-expression of vimentin (show VIM Antibodies) through active DNA demethylation, and cause partial epithelial-to-mesenchymal (EMT (show ITK Antibodies)) in A2780 cells.
these findings suggest that Tet1 expression plays a critical role in metastasis of lung cancer cells by suppression of invasion and epithelial-mesenchymal transition (EMT (show ITK Antibodies)).
TET1, TET2 (show TET2 Antibodies), and TET3 (show TET3 Antibodies) genes are downregulated in endometriosis.
Noncovalent binding of ADP-ribose polymers with TET1 catalytic domain decreases TET1 hydroxylase activity while the covalent PARylation stimulates TET1 enzyme. In addition, TET1 activates PARP-1/ARTD1 (show PARP1 Antibodies) independently of DNA breaks.
Expression levels of TET1 are low in renal carcinoma (show TSC2 Antibodies), particularly in high grade tumors.
our study demonstrated that DNA hypomethylation at the TET1 promoter was associated with childhood asthma in African Americans.
Identify of MLL (show MLL Antibodies)-fusion/MYC (show MYC Antibodies) dash, verticalmiR-26 dash, verticalTET1 signaling circuit in MLL (show MLL Antibodies)-rearranged acute myeloid leukemia (show BCL11A Antibodies).
The expression (mRNA and protein levels) of DNMT1 (show DNMT1 Antibodies) and TET1 is increased in PFC (show CFP Antibodies) of SZ and BP disorder patients.
results suggest that the miR (show MLXIP Antibodies)-29a-Tet1 pathway upregulates MyoD (show MYOD1 Antibodies) expression and conversely downregulates Cdk6 (show CDK6 Antibodies) expression
results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty (show LEFTY2 Antibodies)-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (show DNMT3A Antibodies) and DNMT3B (show DNMT3B Antibodies); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (show HELLS Antibodies) and demethylation crucial to regulation of key signalling pathways in early body plan formation
TET1 accelerates neurogenesis onset time in the fetal brain.TET1 appears to not be associated with gliogenesis during fetal brain development.
Reprogramming of spermatogonial stem cells from Tet1 and Tet2 (show TET2 Antibodies) double knockout mice however lacked demethylation of H19 (show NCKAP1 Antibodies) imprinting control regions.
The critical roles of TET1/2 individually.
These results uncover the hypermethylation of DNA methylation (show HELLS Antibodies) canyons as the genomic key feature of Tet1/Tet2 (show TET2 Antibodies) double-knockout mouse embryonic fibroblasts.
Lin28A (show LIN28A Antibodies) binds active promoters and recruits Tet1 to regulate gene expression via epigenetic DNA modifications.
Knockdown of Tet1 and Tet3 (show TET3 Antibodies) by RNAi in ex vivo cerebellar slice cultures inhibits dendritic arborization of developing cerebellar granule cells, a critical step in circuit formation
findings demonstrate that DAZL (show DAZL Antibodies) associates with mRNA of Tet1, a catalyst of 5-hydroxylation of methyl-cytosine, and enhances Tet1 mRNA translation; DAZL (show DAZL Antibodies) enhances TET1-mediated cytosine hydroxymethylation in embryonic stem cells that are actively reprogramming to a pluripotent ground state
The miR (show MLXIP Antibodies)-29b/Tet1 regulatory axis promotes the mesendoderm lineage formation by inducing the Nodal signaling pathway and repressing the key target of the active demethylation pathway, thymine DNA glycosylase (show TDG Antibodies).
TET3 (show TET3 Antibodies) dioxygenase was present in the very first embryo stages, in contrast to TET1 and AICDA (show AICDA Antibodies).
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5- hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification.
CXXC finger 6
, CXXC zinc finger 6
, CXXC-type zinc finger protein 6
, leukemia-associated protein with a CXXC domain
, methylcytosine dioxygenase TET1
, ten-eleven translocation 1 gene protein
, ten-eleven translocation-1
, tet oncogene 1
, ten-eleven translocation 1 gene protein homolog
, tet methylcytosine dioxygenase 1