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Browse our anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) Antibodies

Full name:
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 Antibodies (HSD11B2)
On www.antibodies-online.com are 97 Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) Antibodies from 18 different suppliers available. Additionally we are shipping Hydroxysteroid (11-Beta) Dehydrogenase 2 Kits (22) and Hydroxysteroid (11-Beta) Dehydrogenase 2 Proteins (10) and many more products for this protein. A total of 136 Hydroxysteroid (11-Beta) Dehydrogenase 2 products are currently listed.
Synonyms:
11-HSD2, 11HSD2, AME, AME1, HSD2, HSD11B2, HSD11K, MGC81883, SDR9C3
list all antibodies Gene Name GeneID UniProt
HSD11B2 3291 P80365
HSD11B2 15484 P51661
HSD11B2 25117 P50233

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Most Popular Reactivities for anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) Antibodies

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All available anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 Antibodies

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Top referenced anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 Antibodies

  1. Cow (Bovine) Polyclonal HSD11B2 Primary Antibody for WB - ABIN2776772 : Subtil-Rodríguez, Millán-Ariño, Quiles, Ballaré, Beato, Jordan: Progesterone induction of the 11beta-hydroxysteroid dehydrogenase type 2 promoter in breast cancer cells involves coordinated recruitment of STAT5A and progesterone receptor to a distal enhancer and polymerase tracking. in Molecular and cellular biology 2008 (PubMed)

  2. Human Polyclonal HSD11B2 Primary Antibody for IF (p), IHC (p) - ABIN701680 : Ding, Shi, Han, Cui: Regulation of glucocorticoid-related genes and receptors/regulatory enzyme expression in intrauterine growth restriction filial rats. in Life sciences 2016 (PubMed)

  3. Human Polyclonal HSD11B2 Primary Antibody for FACS, IHC (p) - ABIN950176 : Mericq, Medina, Kakarieka, Márquez, Johnson, Iñiguez: Differences in expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 and 2 in human placentas of term pregnancies according to birth weight and gender. in European journal of endocrinology / European Federation of Endocrine Societies 2009 (PubMed)

More Antibodies against Hydroxysteroid (11-Beta) Dehydrogenase 2 Interaction Partners

Human Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

  1. activation of Hedgehog (show SHH Antibodies) signaling is crucial for the upregulation and maintenance of 11beta-HSD2 expression in placenta

  2. Reciprocal regulation of the glucocorticoid metabolizing enzymes, 11beta-hydroxysteroid dehydrogenase types 1 and 2, is associated with steroid-responsiveness and disease remission in childhood nephrotic syndrome.

  3. Rac1 GTPase (show RACGAP1 Antibodies) regulates 11beta-HSD2 expression, mineralocorticoid receptor (show NR3C2 Antibodies) activation, and mineralocorticoid receptor (show NR3C2 Antibodies)-mediated pro-fibrotic signaling.

  4. enhancer of zeste homolog 2 (EZH2 (show EZH2 Antibodies)) accounts for the silence of 11beta-HSD2 expression via trimethylation of histone H3 (show HIST3H3 Antibodies) lysine 27 at the promoter of the 11beta-HSD2 gene.

  5. Sensitivity to glucocorticoids did not appear to be mediated by changes in the expression of the beta variant of the glucocorticoid receptor or the 11-beta hydroxysteroid dehydrogenase 2 isozyme.

  6. Review of the role of HSD11B2 in pregnancy complications, fetal diseases, and later life morbidity.

  7. Since increased DNA methylation (show HELLS Antibodies) in HSD11B2 and FKBP5 (show FKBP5 Antibodies) are seen in a minority of bisulfite sequencing clones, these epigenetic changes, and functional consequences, may affect subpopulations of placental cells.

  8. significant positive correlation between DNA methylation of 11beta-HSD2 CpG 1 in infants and maternal sensitivity.

  9. The 11beta-HSD2 expression decreased in pre-eclamptic women of Chinese Han ethnicity, but was not interrelated with the promoter methylation status.

  10. zearalenone is a selective inhibitor of HSD11B2, implying that this agent may cause excessive glucocorticoid action in local tissues such as kidney and placentas.

Pig (Porcine) Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

  1. These results indicate that the effects of maternal protein restriction on placental 11beta-HSD2 expression are gender-dependent in the pig, and thyroid hormones may be involved in such effects.

  2. Postnatal ontogeny of 11beta-HSD2 gene expression is described for the first time in stress-related brain regions of domestic pigs at 7, 21, and 35 days of age.

  3. concluded that the 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 (show HSD11B1 Antibodies) and 2) system is involved in the regulation of cortisol activity in the testis and thus in the regulation of spermatogenesis

  4. Effects of age, weaning and/or social isolation on the expression of genes regulating HSD11B2.

  5. The expression of 11beta-HSD2 in several types of cells forms consecutive lines of defense may protect spermatogonia against glucocorticoid-induced apoptosis.

  6. 11beta-HSD (show HAL Antibodies) type 2, which is abundantly expressed, plays important roles in cortisol inactivation in pig Leydig cells.

  7. The amount of 11beta-HSD 2 in germ cells was greatest at birth, decreased thereafter and was absent after Week 3.

Cow (Bovine) Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

  1. investigation of expression for 11HSD1, 11HSD2, and glucocorticoid receptor (show NR3C1 Antibodies) during follicular maturation and atresia: in atretic follicles, expression of 11HSD2 increased in both granulosa cells and theca interna layers

Mouse (Murine) Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

  1. Rac1 GTPase (show RACGAP1 Antibodies) regulates 11beta-HSD2 expression, mineralocorticoid receptor (show NR3C2 Antibodies) activation, and mineralocorticoid receptor (show NR3C2 Antibodies)-mediated pro-fibrotic signaling.

  2. Nr3c2 (show NR3C2 Antibodies) has a role in mouse skin development in a process that involves HSD11B1 (show HSD11B1 Antibodies)/HSD11B2

  3. Reduced brain 11betaHSD2 promotes a hunger for salt and salt sensitivity. 11betaHSD2-positive neurons integrate salt appetite and the blood pressure response to dietary sodium through a mineralocorticoid receptor (show NR3C2 Antibodies)-dependent pathway.

  4. 11betaHSD2 inhibition suppressed lung tumor growth and invasion in association with increased tissue active glucocorticoid levels, decreased COX-2 (show COX2 Antibodies) expression, inhibition of ERK (show EPHB2 Antibodies) and mTOR (show FRAP1 Antibodies) signaling pathways.

  5. results show that intestinal epithelial 11ssHSD2 activity contributes to increased COX-2 (show COX2 Antibodies) expression in Apc (show APC Antibodies)+/min intestinal adenomas and that 11ssHSD2 deficiency in intestinal epithelial cells suppresses adenoma development and growth

  6. 11beta-hydroxysteroid dehydrogenase-2 is a cortisol-inactivating enzyme with a role in keratinocyte cell proliferation and basal cell proliferation

  7. Reduced 11beta-hydroxysteroid dehydrogenase type 2 causes salt sensitivity of blood pressure because of impaired renal natriuretic capacity.

  8. findings implicate DNA methylation (show HELLS Antibodies) as a mechanism by which prenatal stress alters HSD11B2 gene expression

  9. This study found that 11beta-hydroxysteroid dehydrogenase type 2 knockout mice develop nephrogenic diabetes insipidus (show AVPR2 Antibodies).

  10. HSD2 inhibition and increasing corticosterone adult physiological levels both can independently upregulate neural progenitor cell apoptosis in the perinatal period.

Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) Antigen Profile

Antigen Summary

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.

Alternative names and synonyms associated with Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2)

  • hydroxysteroid (11-beta) dehydrogenase 2 (hsd11b2) antibody
  • hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2) antibody
  • hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2) antibody
  • NAD-dependent 11-beta-hydroxysteroid dehydrogenase (HSD11K) antibody
  • 11-HSD2 antibody
  • 11HSD2 antibody
  • AME antibody
  • AME1 antibody
  • HSD2 antibody
  • HSD11B2 antibody
  • HSD11K antibody
  • MGC81883 antibody
  • SDR9C3 antibody

Protein level used designations for HSD11B2

hydroxysteroid (11-beta) dehydrogenase 2 , corticosteroid 11-beta-dehydrogenase isozyme 2 , 11 beta-hydroxysteroid dehydrogenase type 2 , -HSD11 type II , 11-DH2 , 11-beta-HSD2 , 11-beta-hydroxysteroid dehydrogenase type 2 , 11-beta-hydroxysteroid dehydrogenase type II , NAD-dependent 11-beta-hydroxysteroid dehydrogenase , short chain dehydrogenase/reductase family 9C member 3 , 11-beta hydroxysteroid dehydrogenase , hydroxysteroid 11-beta dehydrogenase 2 , 11-beta-hydroxysteroid dehydrogenase 2 , 11(beta)-HSD2 , Hydroxysteroid dehydrogenase, 11 beta type 2

GENE ID SPECIES
444491 Xenopus laevis
100034124 Equus caballus
100529249 Felis catus
3291 Homo sapiens
396948 Sus scrofa
282434 Bos taurus
100009531 Oryctolagus cuniculus
489758 Canis lupus familiaris
15484 Mus musculus
25117 Rattus norvegicus
443530 Ovis aries
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