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Browse our UGT1A1 Proteins (UGT1A1)

Full name:
UDP Glucuronosyltransferase 1 Family, Polypeptide A1 Proteins (UGT1A1)
On are 3 UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) Proteins from 3 different suppliers available. Additionally we are shipping UGT1A1 Antibodies (38) and UGT1A1 Kits (12) and many more products for this protein. A total of 59 UGT1A1 products are currently listed.
BILIQTL1, Gnt1, HUG-BR1, Udpgt, Udpgt-1a, UDPGT 1-1, Ugt1, UGT1A, UGT1A01, UgtBr1
list all proteins Gene Name GeneID UniProt
UGT1A1 54658 P22309
Mouse UGT1A1 UGT1A1 394436 Q63886
Rat UGT1A1 UGT1A1 24861 Q64550

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UGT1A1 Proteins (UGT1A1) by Origin

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Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) interaction partners

  1. Among patients with increased bilirubin levels, the frequency of UGT1A1*28 is higher than in those with normal bilirubin.

  2. findings showed that almost 57.1% of Chinese colorectal cancer patients had at least one variant of DPYD (show DPYD Proteins)*5A and DPYD (show DPYD Proteins)*9A

  3. Hepatic expression of transcription factors is associated with developmental regulation of UGT1A1 in the Han Chinese population. Moreover, UGT1A1 polymorphisms are associated with reduced expression of UGT1A1 mRNA and protein, as well as enzyme activity.

  4. data provide the implication of UGT1A1 and SLCO1A2 in sickle cell anemia-related cholelithiasis.

  5. The frequency of the UGT1A1*6 allele was significantly higher in breast cancer and gastrointestinal cancer patients than that in healthy females.

  6. Our findings demonstrate that UGT1A1 (TA)n polymorphism is not the only factor triggering gallstone formation in SCD (show SCD Proteins). Cholelithiasis is also modulated by RET (show RET Proteins) count, the number of deleted alpha-genes, HU therapy and the frequency of vaso-occlusive events.

  7. The genotype frequencies for the UGT1A1 polymorphism at position -211 were associated with the histological type of gastric cancer, in which patients with GG genotype showed a predisposition to developing tubular adenocarcinoma. In addition, polymorphisms at positions *28 and -3156 were correlated with the depth of invasion where patients carrying 6TAA or G allele tended to have a local invasion.

  8. The serum bilirubin levels seem to be affected by the homozygosity or heterozygosity of the UGT1A1 gene mutation; 211G>A homozygous mutation is an important factor that causes a rise in bilirubin in neonates with unconjugated hyperbilirubinemia

  9. Dimerization changed the chemical regioselectivity, substrate-binding affinity, and enzymatic activity of UGT1A1 and UGT1A9 (show UGT1A9 Proteins) in glucuronidation of quercetin.

  10. novel genetic score model improved the predictive value of UGT1A1 on SIRD. If validated, it will provide valuable information for clinical use of irinotecan

Mouse (Murine) UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) interaction partners

  1. data confirm that Ugt1a proteins are present and active in preimplantation murine embryos and point to a potential role for these proteins in implantation and early embryonic and fetal development

  2. Intestinal induction of the UGT1A1 gene may serve to limit toxicity and improve the efficacy associated with CPT (show DHDDS Proteins)-11 colorectal cancer treatment.

  3. Data observed that OSM (show OSM Proteins) positively augmented the CAR and UGT1A1 expressions and CAR-mediated signaling in vivo and in vitro, through cross talk between the nuclear CAR receptor and the plasma membrane OSM (show OSM Proteins) receptor, via the MAPK (show MAPK1 Proteins) cascade.

  4. suppression of AhR (show AHR Proteins) signaling pathway is associated with the down-regulation of Ugt1a mRNA during urinary bladder carcinogenesis.

  5. Nrf2 (show NFE2L2 Proteins)-Keap1 (show KEAP1 Proteins)-dependent UGT1A1 induction by prooxidants might represent a key adaptive response to cellular oxidative stress

  6. the loss of UGT1A function in Ugt1(-/-) mice leads to a metabolic syndrome that can serve as a model to further investigate the toxicities associated with unconjugated bilirubin and the impact of this disease in humans.

UGT1A1 Protein Profile

Protein Summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

Alternative names and synonyms associated with UGT1A1

  • UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1)
  • UDP glucuronosyltransferase 1 family polypeptide A1 (LOC100125517)
  • UDP glucuronosyltransferase 1 family, polypeptide A1 (LOC100226997)
  • UDP glucuronosyltransferase 1 family, polypeptide A1 (LOC100229734)
  • UDP glucuronosyltransferase 1 family, polypeptide A1 (Ugt1a1)
  • BILIQTL1 protein
  • Gnt1 protein
  • HUG-BR1 protein
  • Udpgt protein
  • Udpgt-1a protein
  • UDPGT 1-1 protein
  • Ugt1 protein
  • UGT1A protein
  • UGT1A01 protein
  • UgtBr1 protein

Protein level used designations for UGT1A1

UDP glucuronosyltransferase 1 family, polypeptide A1 , UDP-glucuronosyltransferase 1A1 , uridine diphosphate glucuronosyltransferase 1A1 , UDP-glucuronosyltransferase 1-1 , UDP glycosyltransferase 1 family, polypeptide A1 , UDP-glucuronosyltransferase UGT1A01 , UDP glucuronosyltransferase 1 family polypeptide A1 , UDP glycosyl transferase 1A1 , UDP-glucuronosyltransferase 1-1-like , UDP-glucuronosyltransferase 1-A , UGT-1A , UGT1*1 , UGT1-01 , UGT1.1 , bilirubin UDP-glucuronosyltransferase 1-1 , bilirubin UDP-glucuronosyltransferase isozyme 1 , bilirubin-specific UDPGT isozyme 1 , UDP-glucuronosyltransferase 1 family, member 1 , UDP-glucuronosyltransferase 1 family, polypeptide A1 , UDPGT , B1 , UDP-glucuronosyltransferase 1 family member 1

449596 Pan troglodytes
493955 Felis catus
574210 Macaca mulatta
751790 Bos taurus
100065342 Equus caballus
100125517 Oryzias latipes
100126701 Papio anubis
100226997 Taeniopygia guttata
100229734 Taeniopygia guttata
100405984 Callithrix jacchus
100511479 Sus scrofa
100534644 Ovis aries
54658 Homo sapiens
394436 Mus musculus
24861 Rattus norvegicus
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