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Browse our UGT1A1 Proteins (UGT1A1)

Full name:
UDP Glucuronosyltransferase 1 Family, Polypeptide A1 Proteins (UGT1A1)
On www.antibodies-online.com are 3 UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) Proteins from 3 different suppliers available. Additionally we are shipping UGT1A1 Antibodies (37) and UGT1A1 Kits (14) and many more products for this protein. A total of 60 UGT1A1 products are currently listed.
Synonyms:
BILIQTL1, Gnt1, HUG-BR1, Udpgt, Udpgt-1a, UDPGT 1-1, Ugt1, UGT1A, UGT1A01, UgtBr1
list all proteins Gene Name GeneID UniProt
UGT1A1 54658 P22309
Mouse UGT1A1 UGT1A1 394436 Q63886
Rat UGT1A1 UGT1A1 24861 Q64550

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UGT1A1 Proteins (UGT1A1) by Origin

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Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) interaction partners

  1. UGT1A1 rs6742078 is strongly associated with bilirubin levels; however, a 2-stage least-squares Mendelian randomization analysis shows no causal relationship between serum bilirubin and stroke risk.

  2. These data suggest that the UGT1A1*28 polymorphism may not be a suitable biomarker to predict irinotecan-induced toxicities and chemotherapy tumor response in Asians--{REVIEW]

  3. Genetic polymorphisms of the UGT1A1 promoter, specifically the T-3279G phenobarbital-responsive enhancer module and (TA)7 dinucleotide repeat, as well as the intron and coding region variants of the OATP2 (show SLCO1B1 Proteins), HMOX1 (show HMOX1 Proteins), and BLVRA (show BLVRA Proteins) genes, were significantly higher among the cases than the controls.

  4. UGT1A1 variations have a role in chemotherapy-induced unconjugated hyperbilirubinemia in pediatric leukemia patients

  5. UGT1A1*28*28 genotype was significantly associated with lung cancer compared to other malignancies.

  6. these results suggest the presence of the UGT1A1*28 allele does not contribute significantly to a large inter-subject variability in the pharmacokinetics of silybin A and silybin B which may obscure the ability to detect beneficial effects of silymarin in patients with liver disease.

  7. UGT1A1 can control neurodevelopment by regulating serum Thyroxine levels.

  8. Data suggest that microRNA-375 acts as repressor of UGT1A1- (UDP glucuronosyltransferase 1A1-) mediated hepatic acetaminophen glucuronidation through reduced AhR (aryl hydrocarbon receptor (show AHR Proteins)) expression; variations could predispose some individuals to increased risk for acetaminophen-induced liver injury.

  9. Cadmium and arsenic override NF-kappaB (show NFKB1 Proteins) developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia.

  10. Among patients with increased bilirubin levels, the frequency of UGT1A1*28 is higher than in those with normal bilirubin.

Mouse (Murine) UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) interaction partners

  1. data confirm that Ugt1a proteins are present and active in preimplantation murine embryos and point to a potential role for these proteins in implantation and early embryonic and fetal development

  2. Intestinal induction of the UGT1A1 gene may serve to limit toxicity and improve the efficacy associated with CPT (show DHDDS Proteins)-11 colorectal cancer treatment.

  3. Data observed that OSM (show OSM Proteins) positively augmented the CAR and UGT1A1 expressions and CAR-mediated signaling in vivo and in vitro, through cross talk between the nuclear CAR receptor and the plasma membrane OSM (show OSM Proteins) receptor, via the MAPK (show MAPK1 Proteins) cascade.

  4. suppression of AhR (show AHR Proteins) signaling pathway is associated with the down-regulation of Ugt1a mRNA during urinary bladder carcinogenesis.

  5. Nrf2 (show NFE2L2 Proteins)-Keap1 (show KEAP1 Proteins)-dependent UGT1A1 induction by prooxidants might represent a key adaptive response to cellular oxidative stress

  6. the loss of UGT1A function in Ugt1(-/-) mice leads to a metabolic syndrome that can serve as a model to further investigate the toxicities associated with unconjugated bilirubin and the impact of this disease in humans.

UGT1A1 Protein Profile

Protein Summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

Alternative names and synonyms associated with UGT1A1

  • UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1)
  • UDP glucuronosyltransferase 1 family polypeptide A1 (LOC100125517)
  • UDP glucuronosyltransferase 1 family, polypeptide A1 (LOC100226997)
  • UDP glucuronosyltransferase 1 family, polypeptide A1 (LOC100229734)
  • UDP glucuronosyltransferase 1 family, polypeptide A1 (Ugt1a1)
  • BILIQTL1 protein
  • Gnt1 protein
  • HUG-BR1 protein
  • Udpgt protein
  • Udpgt-1a protein
  • UDPGT 1-1 protein
  • Ugt1 protein
  • UGT1A protein
  • UGT1A01 protein
  • UgtBr1 protein

Protein level used designations for UGT1A1

UDP glucuronosyltransferase 1 family, polypeptide A1 , UDP-glucuronosyltransferase 1A1 , uridine diphosphate glucuronosyltransferase 1A1 , UDP-glucuronosyltransferase 1-1 , UDP glycosyltransferase 1 family, polypeptide A1 , UDP-glucuronosyltransferase UGT1A01 , UDP glucuronosyltransferase 1 family polypeptide A1 , UDP glycosyl transferase 1A1 , UDP-glucuronosyltransferase 1-1-like , UDP-glucuronosyltransferase 1-A , UGT-1A , UGT1*1 , UGT1-01 , UGT1.1 , bilirubin UDP-glucuronosyltransferase 1-1 , bilirubin UDP-glucuronosyltransferase isozyme 1 , bilirubin-specific UDPGT isozyme 1 , UDP-glucuronosyltransferase 1 family, member 1 , UDP-glucuronosyltransferase 1 family, polypeptide A1 , UDPGT , B1 , UDP-glucuronosyltransferase 1 family member 1

GENE ID SPECIES
449596 Pan troglodytes
493955 Felis catus
574210 Macaca mulatta
751790 Bos taurus
100065342 Equus caballus
100125517 Oryzias latipes
100126701 Papio anubis
100226997 Taeniopygia guttata
100229734 Taeniopygia guttata
100405984 Callithrix jacchus
100511479 Sus scrofa
100534644 Ovis aries
54658 Homo sapiens
394436 Mus musculus
24861 Rattus norvegicus
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