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Human BMP4 ELISA Kit for Sandwich ELISA - ABIN624950
Wozney: The bone morphogenetic protein family and osteogenesis. in Molecular reproduction and development 1992
Show all 17 Pubmed References
Human BMP4 ELISA Kit for Sandwich ELISA - ABIN624951
Wozney: The bone morphogenetic protein family and osteogenesis. in Molecular reproduction and development 1992
Show all 2 Pubmed References
Mouse (Murine) BMP4 ELISA Kit for Sandwich ELISA - ABIN1568654
Huang, Yao, Xie, Fu: 3D bioprinted extracellular matrix mimics facilitate directed differentiation of epithelial progenitors for sweat gland regeneration. in Acta biomaterialia 2016
Chicken BMP4 ELISA Kit for Sandwich ELISA - ABIN414154
Cheng, Leng, Wu, Zhang, Zhang, Xu, Cao, Li, Luan, Li: Expression analysis of bone morphogenetic protein 4 between fat and lean birds in adipose tissue and serum. in Domestic animal endocrinology 2016
Vrtn binds a bmp2b regulatory sequence and acts as a repressor to inhibit its zygotic transcription.
Study found that BMP-2 is negatively regulated by miR (show MYLIP ELISA Kits)-140 during early embryogenesis and bone development in zebra fi sh.
Data show that transcription of organizer-specific bone morphogenetic protein 2b (bmp2b) is directly down-regulated by Nodal and up-regulated by Wnt (show WNT2 ELISA Kits) signal.
Structures of Bmp2a (show BMP2 ELISA Kits), Bmp2b, Bmp4 and Bmp16 were found to be remarkably similar; with residues involved in receptor binding being highly conserved.
FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 transcription, and activation of bmp antagonists, nog2 and grem1a (show GREM1 ELISA Kits).
Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development.
BMP2b signaling in zebrafish embryos substantially decreases emergence of lymphatic endothelial cells.
Data show that BMP2B protein is expressed in a gradient as early as blastula stages.
we identify a previously unappreciated role for the Nodal-transcription factor FoxH1 in mediating cell responsiveness to Bmp further linking the control of these two pathways in the heart
The Bmp2b mutants and mosaic loss-of-function experiments reveal that BMP acts as a repressor of eye-field fate through inhibition of its key transcription factor Rx3, thereby protecting the future telencephalon from acquiring eye identity.
Data indicate that bone morphogenetic protein (BMP) signaling is essential for erythroid differentiation, and in the absence of BMP signaling, precursor cells adopt an endothelial cell (EC) fate.
Osr1 (show OSR1 ELISA Kits)/Osr2 normally repress bmp4 expression in the lateral plate mesoderm prior to respiratory specification.
The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4.
PIAS (show PIAS1 ELISA Kits) proteins have differential ability to regulate signals from the growth factors activin (show Actbeta ELISA Kits), bone morphogenetic protein 4 (BMP4), and Wnt8 (show WNT8A ELISA Kits).
Data show that PV.1A undergoes combinatorial regulation during early Xenopus development as both the direct target of BMP-4 signaling and as the direct and indirect target of positive and negative regulatory factors.
BMP inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation.
Data suggest that the feedback inhibitors BAMBI (show BAMBI ELISA Kits), SMAD6 (show SMAD6 ELISA Kits), and SMAD7 (show SMAD7 ELISA Kits) expand the dynamic BMP4 signaling range essential for proper embryonic patterning and reduce interindividual phenotypic and molecular variability in Xenopus embryos.
limits homeobox (show PRRX1 ELISA Kits) gene expression in the organiser/non-organiser direction
X-epilectin expression is down-regulated by Noggin (show NOG ELISA Kits) and tBR and that this effect is inhibited by BMP4 over-expression
BMP4-dependent expression of Xenopus Grainyhead-like 1 (show GRHL1 ELISA Kits) has a critical role in epidermal differentiation
BMP4 signaling plays a role in the regulation of terminal differentiation of primary equine trophoblast cells via activation of the SMAD1 (show SMAD1 ELISA Kits)/5 pathway
Study shows that BMP4 is overexpressed in hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) tissues and BMP4-induced ID2/CDKN1B (show CDKN1B ELISA Kits) signaling facilitates the proliferation of HCC (show FAM126A ELISA Kits).
Data suggest pituitary cells secrete factor (TSP1) that binds to and inhibits action of BMP2 and BMP4; von Willebrand type C domain of TSP1 is likely responsible for this BMP2/4-binding activity. These studies were initially conducted using cultured cells from ovine pituitary gland and mouse cell line; interactions were confirmed using recombinant human proteins. (TSP1 = thrombospondin-1; BMP = bone morphogenetic protein)
we demonstrate that expression of bone morphogenetic protein 4 (BMP-4) is universally upregulated in human colorectal cancer cells and tissues, resulting in activated BMP signaling
RUNX1T1 (show RUNX1T1 ELISA Kits) serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells
Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level.
Meta-analysis to assess the effect of BMP4 rs17563 polymorphism on nonsyndromic cleft lip with or without cleft palate (NSCL (show NHLH1 ELISA Kits)/P) suggests that the C allele of BMP4 rs17563 may be a risk factor for NSCL (show NHLH1 ELISA Kits)/P among Asians and Caucasians, and may be a protective factor for NSCL (show NHLH1 ELISA Kits)/P in Brazilian population.
this study identified BMP-4 as a potential molecular marker for predicting the invasion and progression of papillary thyroid carcinoma
Bmp4 drives terminal differentiation into mature white rather than brown fat cells. Bmp4 seems to have a dual role in metabolism either promoting or repressing oxidative metabolism in a cell context dependent manner.
Data suggest that serum BMP4 levels are associated with visceral adiposity and may play role in fat distribution; role of BMP4 in males and females may be different; visceral adiposity may predict serum BMP4 levels in females with obesity; serum BMP4 levels are decreased after GLP-1 receptor (show GLP1R ELISA Kits) agonist (exenatide) treatment in obesity. This study was conducted in China.
BMP4 is a potential cause of digital and eye abnormalities in familial dopa-responsive dystonia.
results suggest that bone morphogenetic protein 4 promotes the generation of male germ cells from induced pluripotent stem (iPS (show SLC27A4 ELISA Kits)) cells
These results suggest how BMP4 regulates adipocyte recruitment in subcutaneous (SC) white adipose tissue, and thus promote its beneficial metabolic effects.
Expression of Bmp4 in the ureteric mesenchyme depends on HH signaling and Foxf1 (show FOXF1 ELISA Kits), and that exogenous BMP4 rescued cell proliferation and epithelial differentiation in ureters with abrogated HH signaling or FOXF1 (show FOXF1 ELISA Kits) function.
the effect of titanium (Ti) with nanotopography (Nano) on the endogenous expression of BMP-2 (show BMP2 ELISA Kits) and BMP-4 and the relevance of this process to the nanotopography-induced osteoblast differentiation.
These data indicate that Foxc1 (show FOXC1 ELISA Kits) expression is regulated by BMP4 and FOXC1 (show FOXC1 ELISA Kits) functions in the commitment of progenitor cells to the osteoblast fate and its expression is reduced when differentiation proceeds.
Treatment of ES cells with TPO (show THPO ELISA Kits) induced the autocrine production of BMP4 with concomitant upregulation of the BMP receptor BMPR1A (show BMPR1A ELISA Kits), phosphorylation of SMAD1 (show SMAD1 ELISA Kits), 5, 8, and activation of specific BMP4 target genes; this was mediated by TPO (show THPO ELISA Kits)-dependent binding of transcription factor HIF-1alpha (show HIF1A ELISA Kits) to the BMP4 gene promoter.
Data suggest that ovarian Bmp4 levels are significantly decreased in a mouse model of polycystic ovary syndrome with hyperandrogenism; androgens inhibited Bmp4 expression via activation of androgen receptors; Smad4 (show SMAD4 ELISA Kits) signaling rather than p38 MAPK (show MAPK14 ELISA Kits) pathway regulates androgen and estrogen formation.
tightly spatial interaction of FSTL1 (show FSTL1 ELISA Kits) and BMP4 signaling plays an essential role in lung development
High BMP4 expression is associated with cystic ovarian disease.
Bone morphogenetic protein 4 and retinoic acid trigger bovine VASA homolog (show DDX4 ELISA Kits) expression in differentiating bovine induced pluripotent stem cells.
The BMP2/4 ligand and receptor system presides within bovine trophectoderm prior to uterine attachment. BMP4 negatively impacts CT1 (show SLC6A8 ELISA Kits) cell growth
BMP4 during maturation increased the proportion of Oct-4 (show POU5F1 ELISA Kits) positive cells in parthenogenic embryos. BMP4 is implicated in bovine oocytes maturation and embryo development.
analysis of polymorphic CA microsatellites in the third exon of the bovine BMP4 gene
concluded that a bone morphogenetic protein (BMP)-signaling system, consisting of BMP2, BMP4, type II and I receptors, is present in bovine antral follicles and plays a role in development and functioning of follicles rather than in oocyte maturation
Data report that BMP-7 (show BMP7 ELISA Kits) suppresses granulosa cell apoptosis by inhibiting the release of caspase-activated DNase (CAD (show DFFB ELISA Kits)) via a mechanism which does not appear to be associated with the mitochondrial pathway, whereas BMP-4 inhibits the release of CAD (show CAD ELISA Kits).
Heat shock protein 70 (show HSP70 ELISA Kits) enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein (show MGP ELISA Kits).
A microsatellite (ACn (show ACIN1 ELISA Kits)) was identified in the 3' UTR (show UTS2R ELISA Kits) of BMP4 gene.Prolificacy associated microsatellite (AC19 (show POLR1D ELISA Kits)) was detected in Indian goats.
paracrine signals from the embryo, represented by FGF4 (show FGF4 ELISA Kits) and BMP4, induce a response in the trophoblast prior to the extensive elongation.
The structure of porcine BMP4 gene is highly conservative with other mammalian BMP4 genes, but some differences may be present in the regulation of gene expression.
Altered shear stress stimulates upregulation of endothelial VCAM-1 (show VCAM1 ELISA Kits) and ICAM-1 (show ICAM1 ELISA Kits) in a BMP-4- and TGF-beta1 (show TGFB1 ELISA Kits)-dependent pathway.
The TM-induced characteristic changes in the expression pattern of Hoxa11 (show HOXA11 ELISA Kits) and Bmp4 on GDs (show PAEP ELISA Kits) 10 and/or 11 were not noted.
BMP4 is expressed peripherally in hypoblast and epiblast and in the mesoderm at the posterior pole of the embryonic disc.
Data show that BMP-2 (show BMP2 ELISA Kits), BMP-4, and BMP-7 (show BMP7 ELISA Kits), noggin (show NOG ELISA Kits), and chordin (show CHRD ELISA Kits) were colocalized in rimming osteoblasts, osteoclasts, and chondrocytes.
Both of the adenovirus-containing bone morphogenetic protein transduced MSCs expressed BMP4 mRNA and protein and underwent osteogenic differentiation.
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
, bone morphogenetic protein-4
, bone morphogenetic protein 4
, bone morphogenetic protein 4, isoform 3
, Bone morphogenetic protein 4
, bone morphogenetic protein 4-like
, bone morphogenetic protein 2
, bone morphogenetic protein 2B