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data indicate variable expression of progesterone receptor membrane component 1 (show PGRMC1 Proteins) and 2 and serpine mRNA binding protein 1 mRNA and protein in bovine corpus luteum and suggest that progesterone may regulate corpus luteum function via its membrane receptors
Data suggest that expression of PGRMC2 varies with region of oviduct (muscle; epithelium; stroma); this represents first evidence of PGRMC2 expression in bovine oviduct. Expression of PGRMC2 in bovine oviduct is both nuclear and cytoplasmic.
Demonstrate a change in myometriumPGRMC1 expression and changes in PGRMC1 (show PGRMC1 Proteins) and PGRMC2 cell localisation in association with parturition.
It deserves further examination as data point to a role of PGRMC2 as tumor suppressor, migration inhibitor and regulator of cytochrome P450 proteins.
In secretory phase endometrium from women with advanced stage endometriosis, PGRMC-2 expression is downregulated.
Reversely, in the HO-8910 cells treated with CDDP alone, levels of both PGRMC1 (show PGRMC1 Proteins) and PGR (show PGR Proteins) were increased while the level of PGRMC2 was decreased
PGRMC2 inhibits migration of SKOV-3 ovarian cancer cells in vitro.
The expression of a novel progesterone-binding protein (show PGRMC1 Proteins) (hmPR1/PGMRC1) was investigated. Transcripts of this protein have been detected in human sperm.
Receptor for steroids (Potential).
progesterone receptor membrane component 2
, progesterone membrane binding protein
, membrane-associated progesterone receptor component 2
, steroid receptor protein DG6