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results suggest that the cyclic ADP-ribose signaling pathway participates in the contraction of small coronary arterial smooth muscle and Ca(2 (show CA2 Proteins)+) release induced by activation of M(1) muscarinic receptors
We find that, as in V1, most parvalbumin (show PVALB Proteins) neurons in MT express m1 AChRs but, unlike in V1, it appears that so do most excitatory neurons.
Receptor Species-dependent Desensitization Controls KCNQ1 (show KCNQ1 Proteins)/KCNE1 (show KCNE1 Proteins) K+ Channels as Downstream Effectors of Gq Protein-coupled Receptors.(
There were no significant associations between CHRM1 SNPs and autonomic nervous system activity in patients with schizophrenia on high-dose antipsychotics.
this study highlights how the properties of affinity and cooperativity can be differentially modified on a common structural scaffold and identifies molecular features that can be exploited to tailor the development of M1 mAChR (show CHRM3 Proteins)-targeting PAMs.
CHRM2 (show CHRM2 Proteins) but not CHRM1 or CHRM3 (show CHRM3 Proteins) polymorphisms are associated with asthma susceptibility in Mexican patients.
the levels were comparable for complexes containing GluR2 (show GRIA2 Proteins), GluR3 (show GRIA3 Proteins) and GluR4 (show GRIA4 Proteins) as well as 5-HT1A (show HTR1A Proteins). Moreover, the levels of complexes containing muscarinic AChR M1, NR1 (show GRIN1 Proteins) and GluR1 (show GRIA1 Proteins) were significantly increased in male patients with AD.
We show that BQCA potentiates agonist-induced beta-arrestin recruitment to M1 mAChRs.
In patients with schizophrenia, both cell body staining and elevated M1 muscarinic receptor (show CHRM5 Proteins) reactivity correlated with higher symptom scores.
demonstrate that activation of M1 muscarinic acetylcholine receptor augments the restitution of epithelial barrier function in T84 cell monolayers after ethanol-induced epithelial injury, via ERK-dependent phosphorylation of focal adhesion kinase
A breakdown in gene promoter methylation control of CHRM1 expression contributes to the global pathophysiology of schizophrenia.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
The three receptor sets considered (mAChR (show CHRM3 Proteins), AR and TrkB (show NTRK2 Proteins) receptors) intervene in modulating the conditions of the competition between nerve endings.
The memory deficits in mouse prion (show PRNP Proteins) disease were completely restored by treatment with benzyl quinolone carboxylic acid (BQCA) and benzoquinazoline-12 (BQZ-12), two highly selective positive allosteric modulators (PAMs) of M1 mAChRs. Furthermore, prolonged exposure to BQCA markedly extended the lifespan of diseased mice.
Data suggest that the inositol phosphate accumulation assay has utility for the evaluation of M1 muscarinic acetylcholine receptor (show CHRNB1 Proteins) activators in vivo.
determining the phosphorylation status of the M1 mAChR (show CHRM3 Proteins) at Ser (show SIGLEC1 Proteins)(228) not only provides a means of establishing receptor activation following drug treatment both in vitro and in vivo but also allows for the mapping of the activation status of the M1 mAChR (show CHRM3 Proteins) in the hippocampus
M1 Muscarinic Receptor (show CHRM5 Proteins) Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice
High M1 muscarinic receptor (show CHRM5 Proteins) expression is associated with acute liver injury.
This study demonistrated that Expression of m1-type muscarinic acetylcholine receptors by parvalbumin (show PVALB Proteins)-immunoreactive neurons in the primary visual cortex
The mm (chi(1 (show GRIN3A Proteins)) congruent with -60 degrees ; chi(2) congruent with -60 degrees ) and tp (chi(1 (show GRIN3A Proteins)) congruent with 180 degrees ; chi(2) congruent with +60 degrees ) rotamers were identified as the likely conduction-catalyzing conformations of the AChR's selectivity-filter glutamates.
The results of this study suggested that M1-muscarinic receptors promote fear memory consolidation via phospholipase C (show PLC Proteins) and the M-current.
M1 receptor is co-localized with VGLUT2 on the intraganglionic laminar endings of esophagus.
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
muscarinic acetylcholine receptor M1
, muscarinic receptor
, cholinergic receptor, muscarinic 1
, acetylcholine receptor, muscarinic 1
, Cholinergic receptor, muscarin 1
, m1 muscarinic acetylcholine receptor protein
, AChR M1
, muscarinic acetylcholine receptor 1