Browse our NMDAR2A Proteins (GRIN2A)

On are 9 Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A) Proteins from 2 different suppliers available. Additionally we are shipping NMDAR2A Antibodies (238) and NMDAR2A Kits (28) and many more products for this protein. A total of 280 NMDAR2A products are currently listed.
list all proteins Gene Name GeneID UniProt
GRIN2A 2903 Q12879
Rat GRIN2A GRIN2A 24409 Q00959
GRIN2A 14811 P35436

NMDAR2A Proteins (GRIN2A) by Origin

More Proteins for NMDAR2A Interaction Partners

Human Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A) interaction partners

  1. 2-methoxyestradiol impacts on glycine/serine-mediated metabolic reprogramming in osteosarcoma cells by its interaction with GRIN1 (show GRIN1 Proteins)/GluN2A receptors.

  2. a de novo missense mutation in the GRIN2A gene in a patient with childhood focal epilepsy and acquired epileptic aphasia. The mutant decreases NMDAR (show GRIN1 Proteins) activation suggesting NMDAR (show GRIN1 Proteins) hypofunction may contribute to the epilepsy pathogenesis.

  3. genetic association studies in population in China: Data suggest that one SNP in GRIN2A (rs2650429; but not rs6497540 or rs9302415) is associated with lead-induced neurotoxicity; in this case-control study, cases were lead-exposed workers from battery plants. Lead-exposed individuals have lower serum GRIN2A levels compared with controls; lead decreases GRIN2A expression levels in HEK293 cell.

  4. Two adjacent phenylalanines in the NMDA receptor GluN2A subunit M3 domain interactively regulate alcohol sensitivity and ion channel gating.

  5. The GRIN2A genotype was not associated with the rate of clinical progression of PD in the placebo group.

  6. most rare variants in GluN2A were associated with epilepsy, whereas GluN2B (show GRIN2B Proteins) variants were associated with intellectual disability with or without seizures

  7. the gain-of-function M817V mutation causes overactivation of NMDAR (show GRIN1 Proteins) and drives neuronal hyperexcitability.

  8. To determine genetic variability within the N-methyl-D-aspartate receptor 2A sub-unit (GRIN2A) gene promoter and its association with concussion recovery time.

  9. Knockdown of PKD1 (show PKD1 Proteins) did not affect NMDAR (show GRIN1 Proteins) internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR (show GRIN1 Proteins)-mediated synaptic functions.

  10. Findings suggest that mutations in GRIN2A preferentially are involved in genetic variance of pediatric idiopathic generalized epilepsy and do not contribute significantly to either adult focal epilepsies as temporal lobe epilepsy or generalized epilepsies

Mouse (Murine) Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A) interaction partners

  1. This study demonstrated that Increasing the GluN2A/GluN2B (show GRIN2B Proteins) Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace.

  2. Grin2aPKC mice exhibit reduced anxiety in the open field test, light dark emergence test, and elevated plus maze. Overall, these results suggest that at least one of those PKC-mediated phosphorylation sites regulates NMDAR (show GRIN1 Proteins)-mediated signaling that modulates anxiety.

  3. These data suggest that chronic early postnatal SSS influences spatial learning and memory ability, levels of hippocampal NR2B (show GRIN2B Proteins), and NR2A/NR2B (show GRIN2B Proteins) ratios in adult males.

  4. Rph3A (show RPH3A Proteins) interacts with GluN2A and PSD-95 (show DLG4 Proteins) forming a complex that regulates NMDARs stabilization at postsynaptic membranes.

  5. Egr-1 (show EGR1 Proteins) is involved in NMDAR (show GRIN1 Proteins)-mediated PSD-95 (show DLG4 Proteins) down-regulation and AMPAR endocytosis, a process important in the expression of long term depression

  6. Study demonstrated that GluN2A carboxy-terminal domain is responsible for the impaired long-term olfactory and social memory observed in the GluN2A overexpression mice

  7. Results establish the GluN2A subunit as a significant contributor to both bidirectional synaptic plasticity and spatial pattern separation in the dentate gyrus

  8. Best1 (show BEST1 Proteins)-mediated astrocytic glutamate (show GRIN1 Proteins) activates the synaptic N-methyl-D-aspartate receptor (show GRIN1 Proteins) (NMDAR (show GRIN1 Proteins)) and modulates NMDAR (show GRIN1 Proteins)-dependent synaptic plasticity.

  9. Data suggest a role for GluN2A in ethanol tolerance.

  10. We conclude that TSPYL2 (show TSPYL2 Proteins) contributes to cognitive variability through regulating the expression of Grin2a and Grin2b (show GRIN2B Proteins).

NMDAR2A (GRIN2A) Protein Profile

Protein Summary

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with NMDAR2A (GRIN2A)

  • glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A)
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2A (grin2a)
  • glutamate receptor ionotropic, NMDA 2A-like (LOC524212)
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2A (Grin2a)
  • glutamate receptor, ionotropic, NMDA2A (epsilon 1) (Grin2a)
  • EPND protein
  • GluN2A protein
  • GRIN2A protein
  • NMDAR2A protein
  • NR2A protein

Protein level used designations for GRIN2A

N-methyl-D-aspartate receptor subunit NR2A , glutamate receptor, ionotropic, N-methyl D-aspartate 2A , glutamate [NMDA] receptor subunit epsilon-1-like , N-methyl D-aspartate receptor subtype 2A , N-methyl-D-aspartate receptor channel, subunit epsilon-1 , N-methyl-D-aspartate receptor subunit 2A , NMDA receptor subtype 2A , glutamate [NMDA] receptor subunit epsilon-1 , glutamate receptor ionotropic, NMDA 2A , hNR2A , glutamate [NMDA] receptor subunit epsilon 1 , glutamate receptor, ionotropic, N-methyl-D-aspartate subunit 2A , GluRepsilon1

778440 Taeniopygia guttata
100127346 Xenopus laevis
100411569 Callithrix jacchus
100438553 Pongo abelii
100584731 Nomascus leucogenys
524212 Bos taurus
2903 Homo sapiens
24409 Rattus norvegicus
100727265 Cavia porcellus
490012 Canis lupus familiaris
427678 Gallus gallus
454396 Pan troglodytes
14811 Mus musculus
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