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Results suggest that orexin A bidirectionally modulates hippocampal CA1 (show CA1 Antibodies) synaptic plasticity, inhibiting long-term potentiation via OX1Rs at moderate concentrations while inducing re-potentiation via OX1Rs and OX2Rs, possibly through phospholipase C (show PLC Antibodies) and adenylyl cyclase-protein kinase A signaling at sub-nanomolar concentrations
DYN (show PDYN Antibodies)-A(2-17) interacts with orexin A in the paraventricular hypothalamic nucleus to modulate food intake in mice.
Awake dynamics and brain-wide direct inputs of hypothalamic MCH (show PMCH Antibodies) and orexin/hypocretin (show OX Antibodies) networks have been discovered.
Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin (show OX Antibodies) Neuron Deficiency
observation that inhibition of the Orexin (show OX Antibodies)-1 receptor signaling blunted binge-like Ethanol, and saccharin drinking suggests that reward-related Orexin (show OX Antibodies) circuits participate in the consumption of salient reinforcers regardless of calories.
Results suggest that exercise produces antidepressant effects via suppression of Hcrt (show OX Antibodies)/Orx and melanin-concentrating hormone (show PMCH Antibodies) neural systems in the basolateral amygdala
Hcrt (show OX Antibodies) neuronal activity and Hcrt (show OX Antibodies)-mediated stress responses were inhibited by the satiety hormone leptin (show LEP Antibodies).
This study demonstrated that the GABAergic input property of orexin (show OX Antibodies) neurons responds rapidly to sleep deprivation.
sleep deprivation or increasing wakefulness by rescue of orexinergic neurons in APP (show APP Antibodies)/PS1 (show PSEN1 Antibodies) mice lacking orexin (show OX Antibodies) increased the amount of amyloid beta pathology in the brain.
orexin (show OX Antibodies) activates the mTOR (show FRAP1 Antibodies) pathway, a central regulator of cell growth and metabolism, in the mouse brain and cell lines that express GPCRs, OX1R (show HCRTR1 Antibodies), or OX2R (show CD200R1 Antibodies)
The aim of the study was to determine by immunochemistry the expression of leptin (show LEP Antibodies), orexin A and orphanin FQ (show PNOC Antibodies) in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow.
first evidence for the expression of oxA and ox1R (show HCRTR1 Antibodies) in the vestibular glands of mammalian genital tract
The impact of the phase of the estrous cycle on the observed changes in plasma orexin (show OX Antibodies) levels in domestic pigs.
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
, orexin A
, orexin B
, Hypocretin (orexin) neuropeptide