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Human SYT1 Protein expressed in Wheat germ - ABIN1322010
Liu, Akle, Zheng, Dave, Tortella, Hayes, Wang: Comparing calpain- and caspase-3-mediated degradation patterns in traumatic brain injury by differential proteome analysis. in The Biochemical journal 2006
tethering of Syt1 to synaptic vesicles in vivo is a prerequisite for its role in facilitating fast synchronous synaptic vesicle release and suppressing asynchronous and spontaneous fusion
synaptic transmission can be regulated by Syt1 multimerization and that both C2 domains of Syt1 are uniquely required for modulating Ca(2 (show CA2 Proteins)+)-independent spontaneous fusion and Ca(2 (show CA2 Proteins)+)-dependent synchronous release.
effect of APP (show APP Proteins) gene on synaptotagmin 1 mRNA level
The major function of Ca2+ binding to synaptotagmin's C2A domain is to neutralize the negative charge of the pocket, thereby unleashing the fusion-stimulating activity of synaptotagmin.
this study provided direct support for the hypothesis that plasma membrane penetration, specifically by the C(2)B domain of synaptotagmin, is the critical effector interaction for coupling Ca(2 (show CA2 Proteins)+) binding with vesicle fusion
Results suggest that the tandem C2 domains of Syt 1 play independent roles in neurotransmission.
The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo
Synaptotagmins I and IV promote transmitter release independently of Ca(2 (show CA2 Proteins)+) binding in the C(2)A domain
Data show that synaptotagmin I is required for a post-docking step during vesicle fusion but does not function to stabilize the docked vesicle state.
These results indicate that synaptotagmin is the major Ca(2 (show CA2 Proteins)+) sensor for evoked release and functions to trigger synchronous fusion in response to Ca(2 (show CA2 Proteins)+), while suppressing asynchronous release.
The function of synaptotagmin-1 (syt-1):soluble NSF attachment protein (show NAPG Proteins) receptor (SNARE (show VTI1B Proteins)) interactions during neurotransmission remains unclear.
we identify Syt2 (show SYT2 Proteins) as a functionally important Ca(2 (show CA2 Proteins)+) sensor at fast-releasing inhibitory synapses, and show that Syt1 and Syt2 (show SYT2 Proteins) can redundantly control transmitter release at specific brain synapses
results suggest that postsynaptic Syt1 and Syt7 (show SYT7 Proteins) act as redundant Ca(2 (show CA2 Proteins)+)-sensors for Ca(2 (show CA2 Proteins)+)-dependent exocytosis of AMPA (show GRIA3 Proteins) receptors during long-term potentiation, and thereby delineate a simple mechanism for the recruitment of AMPA (show GRIA3 Proteins) receptors that mediates LTP (show SCP2 Proteins)
demonstrates a developmental Syt1-Syt2 (show SYT2 Proteins) isoform switch at an identified synapse, a mechanism that could fine-tune the speed, reliability, and plasticity of transmitter release at fast releasing CNS synapses.
the combined inactivation of all 3 E-Syt (show SS18 Proteins) genes has no effect on mouse viability or fertility.
GRASP65 (show GORASP1 Proteins) phosphorylation may have a critical role in inducing cell death.
We conclude that synaptotagmin-1 phosphorylation is an essential step in PKC-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC substrates, Munc13-1 and Munc18-1 (show STXBP1 Proteins).
data show that hepatic Syt1 expression is influenced by diet and hormonal milieu
different structural states of syt (show SS18 Proteins) underlie the control of distinct forms of synaptic transmission.
The interaction of Dvl1 (show DVL1 Proteins) with Syt-1, which is regulated by Wnts, modulates neurotransmitter release.
This study found that the CSF (show CSF2 Proteins) levels of synaptotagmin-1 were consistently elevated in patients with dementia due to Alzheimer's disease.
SYT (show SS18 Proteins)-SSX (show SSX2 Proteins) fusion is associated with synovial sarcoma.
the extended synaptotagmins (E-Syts), endoplasmic reticulum (ER) proteins that function as PtdIns(4,5)P2- and Ca(2 (show CA2 Proteins)+)-regulated tethers to the Pplasma membrane.
Data indicate that small protein sequence changes in the Ca(2 (show CA2 Proteins)+)-binding loops of the C2 domains may give rise to the difference in binding kinetics between Syt-1 and Syt-7 (show SYT7 Proteins) isoforms.
These findings identify Syt1 as a novel Ca(2 (show CA2 Proteins)+)-sensitive PS1 (show PSEN1 Proteins) modulator that could regulate synaptic ABETA (show APP Proteins), opening avenues for novel and selective synapse targeting therapeutic strategies.
One-Step reverse transcriptase real time PCR for the detection SYT (show SS18 Proteins)-SSX (show SSX2 Proteins) transcript is feasible as an aid in confirming the diagnosis of synovial sarcoma.
membrane tethering by E-Syt1 (ER to PM) and by synaptotagmin (secretory vesicles to PM) undergo a similar regulation by plasma membrane lipids and cytosolic Ca(2 (show CA2 Proteins)+).
A dominant negative de novo SYT1 missense variant(I368T)altered the kinetics of synaptic vesicle endocytosis and caused an early onset dyskinetic movement disorder, severe motor delay, and profound cognitive impairment.
Data suggest that calcium-dependent phosphatidylinositol 4,5-diphosphate- (PI(4,5)P2-) binding proteins (such as SYT1, PRKCA (show PKCa Proteins) [protein kinase C alpha (show PKCa Proteins)], and ANXA2 (show ANXA2 Proteins) [annexin A2 (show ANXA2 Proteins)]) interactions with membrane microdomains are tightly regulated. [REVIEW]
Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 (show DDR2 Proteins) rearrangements.
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001
, synaptoptagmin 1
, synaptotagmin 1
, synaptotagmin I
, DKFZP459P193 protein
, Synaptotagmin I
, Golgi reassembly-stacking protein 1
, golgi peripheral membrane protein p65
, golgi reassembly-stacking protein of 65 kDa
, synaptotagmin p65
, synaptotagmin 8
, synaptotagmin I VQ/C2B-beta