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Browse our anti-CBL (CBL) Antibodies

Full name:
anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence Antibodies (CBL)
On are 262 Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Antibodies from 28 different suppliers available. Additionally we are shipping CBL Kits (12) and CBL Proteins (6) and many more products for this protein. A total of 302 CBL products are currently listed.
4732447J05Rik, C-CBL, c-cbl-like, cbl, Cbl-2, CBL2, FRA11B, NSLL, RGD1561386, RNF55
list all antibodies Gene Name GeneID UniProt
CBL 12402 P22682
CBL 867 P22681
CBL 500985  

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Most Popular Reactivities for anti-CBL (CBL) Antibodies

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anti-Mouse (Murine) CBL Antibodies:

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anti-Rat (Rattus) CBL Antibodies:

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Top referenced anti-CBL Antibodies

  1. Chicken Monoclonal CBL Primary Antibody for IF, IP - ABIN967970 : Burke, Schooler, Wiley: Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. in Molecular biology of the cell 2001 (PubMed)
    Show all 5 references for ABIN967970

  2. Human Polyclonal CBL Primary Antibody for IF, IHC (p) - ABIN319293 : Drivas, Shih, Coutavas, DEustachio, Rush: Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3. in Oncogene 1991 (PubMed)
    Show all 4 references for ABIN319293

  3. Human Polyclonal CBL Primary Antibody for IHC (p) - ABIN401654 : Owen-Schaub, Chan, Cusack, Roth, Hill: Fas and Fas ligand interactions in malignant disease. in International journal of oncology 2000 (PubMed)
    Show all 3 references for ABIN401654

  4. Human Polyclonal CBL Primary Antibody for EIA, IF - ABIN499585 : Thien, Langdon: c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses. in The Biochemical journal 2005 (PubMed)

  5. Cow (Bovine) Polyclonal CBL Primary Antibody for EIA, WB - ABIN374153 : Quinones, Jin, Oro: I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration. in The Journal of cell biology 2010 (PubMed)

  6. Human Polyclonal CBL Primary Antibody for IHC (p), WB - ABIN388072 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)

  7. Mouse (Murine) Polyclonal CBL Primary Antibody for ELISA, WB - ABIN184673 : Langdon, Hartley, Klinken, Ruscetti, Morse: v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. in Proceedings of the National Academy of Sciences of the United States of America 1989 (PubMed)

  8. Human Polyclonal CBL Primary Antibody for IF, IHC - ABIN1531307 : Joazeiro, Wing, Huang, Leverson, Hunter, Liu: The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. in Science (New York, N.Y.) 1999 (PubMed)

More Antibodies against CBL Interaction Partners

Mouse (Murine) Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) interaction partners

  1. results demonstrate that c-Cbl mediates the ubiquitination/degradation of integrin beta1, which leads to COMP (show COMP Antibodies) deficiency-induced dilated cardiomyopathy.

  2. Gem (show GEM Antibodies), a gene encoding a GTPase (show RACGAP1 Antibodies) that is upregulated by Cbl(Q367P) , enhanced hematopoietic stem cell activity and induced myeloid cell proliferation. In addition, Evi1 (show MECOM Antibodies), a gene encoding a transcription factor, was found to cooperate with Cbl(Q367P) and progress CMML to AML (show RUNX1 Antibodies).

  3. Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders.

  4. Cbl down-regulation protects mice against high-fat diet-induced obesity and insulin (show INS Antibodies) resistance.

  5. Cbl-b and c-Cbl regulate the degradation of Osterix through the ubiquitin-proteasome pathway.

  6. Overexpression of Smad7 (show SMAD7 Antibodies) in human HaCaT keratinocyte cells and mouse skin tissues elevated EGF receptor (EGFR (show EGFR Antibodies)) activity by impairing ligand-induced ubiquitination and degradation of activated receptor, which is induced by the E3 ubiquitin ligase (show MUL1 Antibodies) c-Cbl.

  7. Erbin (show ERBB2IP Antibodies) promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor (show EGFR Antibodies)

  8. Whereas Cbl-PI3K interaction regulates differentiation and survival, bone resorption is predominantly regulated by Cbl-b in osteoclasts.

  9. c-Cbl activation promotes myocyte apoptosis, inhibits angiogenesis, and causes adverse cardiac remodeling after myocardial infarction.

  10. Data indicate a Cbl/p85 (show ECM1 Antibodies)/epsin-1 (show EPN1 Antibodies) pathway in erythropoietin receptor (EpoR (show EPOR Antibodies)) endocytosis.

Human Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) interaction partners

  1. we report that two JMML patients survived >20 years without HSCT and both patients had uniparental disomy of 11q23 where CBL is located without the phenomenon found in neither Noonan syndrome nor Noonan syndrome-like disorder. We think that some JMML patients with CBL mutation might show the good prognosis in later life after remission of JMML.

  2. we found that CQ decreased the expression of Cbl, an E3 ligase of DR5 (show TNFRSF10B Antibodies), and knock-down of Cbl markedly enhanced DR5 (show TNFRSF10B Antibodies) up-regulation. Other lysosomal inhibitors, including monensin and nigericin, also up-regulated DR5 (show TNFRSF10B Antibodies) and sensitized TRAIL-mediated apoptosis

  3. miR (show MLXIP Antibodies)-513a-5p, miR (show MLXIP Antibodies)-22-3p and miR (show MLXIP Antibodies)-625-5p may have an impact on the regulation of the immune response and inflammatory cytokine pathways through the regulation of their target gene(s), CBL, PPARGC1B (show PPARGC1B Antibodies) and ESR1 (show ESR1 Antibodies), which may then lead to a dust mite-induced asthma attack

  4. Data suggest that the combination of peritumoral Cbl and EGFR (show EGFR Antibodies) serves as a much stronger indicator to make an accurate prognosis, especially during early recurrence.

  5. H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b.

  6. The study reveals a role of CBL in restricting myeloid proliferation of human AML1 (show RUNX1 Antibodies)-ETOinduced leukemia, and identifies UBASH3B (show STS1 Antibodies) as a potential target for pharmaceutical intervention.

  7. By up-regulating the expression of c-Cbl and Cbl-b, which leads to inhibition of PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling and down-regulation of P-gp (show ABCB4 Antibodies) expression, beta-elemene is capable of enhancing the efficacy of doxorubicin in leukemia and gastric cancer cells.

  8. Genotype-phenotype correlation analysis performed on available records indicated that germline CBL mutations cause a variable phenotype characterized by a relatively high frequency of neurological features, predisposition to diseases.

  9. The result indicated that TMZ may overcome TRAIL resistance in GSCs by suppressing c-FLIP (show CFLAR Antibodies) expression through c-Cbl-mediated ubiquitination and degradation

  10. Demonstrate role for CBL in the control of AXL (show AXL Antibodies)/SYK (show SYK Antibodies)/LYN (show LYN Antibodies) network mediating resistance to nilotinib treatment in chronic myeloid leukemia (show BCL11A Antibodies) cells.

CBL Antigen Profile

Antigen Summary

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

Alternative names and synonyms associated with CBL

  • Casitas B-lineage lymphoma (Cbl) antibody
  • Cbl proto-oncogene, E3 ubiquitin protein ligase (CBL) antibody
  • Cbl proto-oncogene, E3 ubiquitin protein ligase (Cbl) antibody
  • 4732447J05Rik antibody
  • C-CBL antibody
  • c-cbl-like antibody
  • cbl antibody
  • Cbl-2 antibody
  • CBL2 antibody
  • FRA11B antibody
  • NSLL antibody
  • RGD1561386 antibody
  • RNF55 antibody

Protein level used designations for CBL

E3 ubiquitin-protein ligase CBL , casitas B-lineage lymphoma proto-oncogene , proto-oncogene c-CBL , signal transduction protein CBL , Cas-Br-M (murine) ecotropic retroviral transforming sequence , RING finger protein 55 , fragile site, folic acid type, rare, fra(11)(q23.3) , oncogene CBL2 , proto-oncogene c-Cbl , Casitas B-lineage lymphoma

12402 Mus musculus
867 Homo sapiens
489369 Canis lupus familiaris
100518854 Sus scrofa
527418 Bos taurus
500985 Rattus norvegicus
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