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Browse our anti-CBL (CBL) Antibodies

Full name:
anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence Antibodies (CBL)
On www.antibodies-online.com are 255 Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Antibodies from 29 different suppliers available. Additionally we are shipping CBL Kits (12) and CBL Proteins (5) and many more products for this protein. A total of 294 CBL products are currently listed.
Synonyms:
4732447J05Rik, C-CBL, c-cbl-like, cbl, Cbl-2, CBL2, FRA11B, NSLL, RGD1561386, RNF55
list all antibodies Gene Name GeneID UniProt
CBL 12402 P22682
CBL 867 P22681
CBL 500985  

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Most Popular Reactivities for anti-CBL (CBL) Antibodies

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anti-Mouse (Murine) CBL Antibodies:

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anti-Rat (Rattus) CBL Antibodies:

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Top referenced anti-CBL Antibodies

  1. Chicken Monoclonal CBL Primary Antibody for IF, IP - ABIN967970 : Burke, Schooler, Wiley: Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. in Molecular biology of the cell 2001 (PubMed)
    Show all 5 references for ABIN967970

  2. Human Polyclonal CBL Primary Antibody for IF, IHC (p) - ABIN319293 : Drivas, Shih, Coutavas, DEustachio, Rush: Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3. in Oncogene 1991 (PubMed)
    Show all 4 references for ABIN319293

  3. Human Monoclonal CBL Primary Antibody for ICC, FACS - ABIN968993 : Sproul, Xu, Wilhelm, Gire, Greene: Cbl negatively regulates JNK activation and cell death. in Cell research 2009 (PubMed)
    Show all 3 references for ABIN968993

  4. Human Polyclonal CBL Primary Antibody for IHC (p) - ABIN401654 : Owen-Schaub, Chan, Cusack, Roth, Hill: Fas and Fas ligand interactions in malignant disease. in International journal of oncology 2000 (PubMed)
    Show all 3 references for ABIN401654

  5. Human Polyclonal CBL Primary Antibody for EIA, IF - ABIN499585 : Thien, Langdon: c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses. in The Biochemical journal 2005 (PubMed)

  6. Human Polyclonal CBL Primary Antibody for IHC (p), WB - ABIN388072 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)

  7. Cow (Bovine) Polyclonal CBL Primary Antibody for EIA, WB - ABIN782892 : Quinones, Jin, Oro: I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration. in The Journal of cell biology 2010 (PubMed)

  8. Mouse (Murine) Polyclonal CBL Primary Antibody for ELISA, WB - ABIN184673 : Langdon, Hartley, Klinken, Ruscetti, Morse: v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. in Proceedings of the National Academy of Sciences of the United States of America 1989 (PubMed)

  9. Human Polyclonal CBL Primary Antibody for IF, IHC - ABIN1531307 : Joazeiro, Wing, Huang, Leverson, Hunter, Liu: The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. in Science (New York, N.Y.) 1999 (PubMed)

More Antibodies against CBL Interaction Partners

Mouse (Murine) Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) interaction partners

  1. Cbl down-regulation protects mice against high-fat diet-induced obesity and insulin (show INS Antibodies) resistance.

  2. Cbl-b and c-Cbl regulate the degradation of Osterix through the ubiquitin-proteasome pathway.

  3. Overexpression of Smad7 (show SMAD7 Antibodies) in human HaCaT keratinocyte cells and mouse skin tissues elevated EGF receptor (EGFR (show EGFR Antibodies)) activity by impairing ligand-induced ubiquitination and degradation of activated receptor, which is induced by the E3 ubiquitin ligase (show MUL1 Antibodies) c-Cbl.

  4. Erbin (show ERBB2IP Antibodies) promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor (show EGFR Antibodies)

  5. Whereas Cbl-PI3K interaction regulates differentiation and survival, bone resorption is predominantly regulated by Cbl-b in osteoclasts.

  6. c-Cbl activation promotes myocyte apoptosis, inhibits angiogenesis, and causes adverse cardiac remodeling after myocardial infarction.

  7. Data indicate a Cbl/p85 (show ECM1 Antibodies)/epsin-1 (show EPN1 Antibodies) pathway in erythropoietin receptor (EpoR (show EPOR Antibodies)) endocytosis.

  8. These results support the notion that the distal cytoplasmic domain of CD5 (show CD5 Antibodies), including Y463, plays a relevant role in the downmodulation of TCR signals in thymocytes via c-Cbl.

  9. c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TbetaRII at Lys556 and Lys567.

  10. the novel role for Syk (show SYK Antibodies) signaling and the Syk (show SYK Antibodies)-binding ubiquitin ligase (show RNF123 Antibodies) c-Cbl in the BCR (show BCR Antibodies)-mediated processing and presentation of cognate antigen and

Human Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) interaction partners

  1. Data suggest that the combination of peritumoral Cbl and EGFR (show EGFR Antibodies) serves as a much stronger indicator to make an accurate prognosis, especially during early recurrence.

  2. H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b.

  3. The study reveals a role of CBL in restricting myeloid proliferation of human AML1 (show RUNX1 Antibodies)-ETOinduced leukemia, and identifies UBASH3B (show STS1 Antibodies) as a potential target for pharmaceutical intervention.

  4. By up-regulating the expression of c-Cbl and Cbl-b, which leads to inhibition of PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling and down-regulation of P-gp (show ABCB4 Antibodies) expression, beta-elemene is capable of enhancing the efficacy of doxorubicin in leukemia and gastric cancer cells.

  5. Genotype-phenotype correlation analysis performed on available records indicated that germline CBL mutations cause a variable phenotype characterized by a relatively high frequency of neurological features, predisposition to diseases.

  6. The result indicated that TMZ may overcome TRAIL resistance in GSCs by suppressing c-FLIP (show CFLAR Antibodies) expression through c-Cbl-mediated ubiquitination and degradation

  7. Demonstrate role for CBL in the control of AXL (show AXL Antibodies)/SYK (show SYK Antibodies)/LYN (show LYN Antibodies) network mediating resistance to nilotinib treatment in chronic myeloid leukemia (show BCL11A Antibodies) cells.

  8. Overexpression of Smad7 (show SMAD7 Antibodies) in human HaCaT keratinocyte cells and mouse skin tissues elevated EGF receptor (EGFR (show EGFR Antibodies)) activity by impairing ligand-induced ubiquitination and degradation of activated receptor, which is induced by the E3 ubiquitin ligase (show MUL1 Antibodies) c-Cbl.

  9. Here we report on three unrelated patients with CBL mutations manifesting with hydrops fetalis, fetal pleural effusions and/or congenital hydro-/chylothorax. Our findings further connect the CBL syndrome with the RASopathies.

  10. These results suggest that dysregulation of ubiquitination is a key mechanism of EGFR (show EGFR Antibodies) hyperactivation in PDAC and that low CBL may define PDAC tumors likely to respond to erlotinib treatment.

CBL Antigen Profile

Antigen Summary

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

Alternative names and synonyms associated with CBL

  • Casitas B-lineage lymphoma (Cbl) antibody
  • Cbl proto-oncogene, E3 ubiquitin protein ligase (CBL) antibody
  • Cbl proto-oncogene, E3 ubiquitin protein ligase (Cbl) antibody
  • 4732447J05Rik antibody
  • C-CBL antibody
  • c-cbl-like antibody
  • cbl antibody
  • Cbl-2 antibody
  • CBL2 antibody
  • FRA11B antibody
  • NSLL antibody
  • RGD1561386 antibody
  • RNF55 antibody

Protein level used designations for CBL

E3 ubiquitin-protein ligase CBL , casitas B-lineage lymphoma proto-oncogene , proto-oncogene c-CBL , signal transduction protein CBL , Cas-Br-M (murine) ecotropic retroviral transforming sequence , RING finger protein 55 , fragile site, folic acid type, rare, fra(11)(q23.3) , oncogene CBL2 , proto-oncogene c-Cbl , Casitas B-lineage lymphoma

GENE ID SPECIES
12402 Mus musculus
867 Homo sapiens
489369 Canis lupus familiaris
100518854 Sus scrofa
527418 Bos taurus
500985 Rattus norvegicus
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