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Current knowledge of the functions of the adapter protein ADAP in T cell signaling with a focus on the role of individual phosphotyrosine (pY) motifs for SH2 domain mediated interactions is presented.
A distinct set of proteins interaction partners required for chemokine (show CCL1 ELISA Kits)-directed T cell migration is attracted by phosphotyrosine 571 of ADAP, including ZAP70 (show ZAP70 ELISA Kits).
Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.
FYB nonsense mutations in humans causing small-platelet thrombocytopenia and a significant bleeding tendency.
Data (including data from studies in knockout/transgenic mice) suggest that ADAP regulates positive feedback loop of TGFbeta1 (show TGFB1 ELISA Kits) production and TGFbeta1 (show TGFB1 ELISA Kits)-induced CD103 (show ITGAE ELISA Kits) expression in CD8 (show CD8A ELISA Kits)+ T-lymphocytes and protects against influenza H5N1 virus infection.
The aim of this study was to perform an association study between seven Fyn-binding protein gene (FYB)-tag single nucleotide polymorphisms (SNPs) and type I diabetes mellitus (T1DM), as well as with disease age of onset.
The autosomal recessive bleeding phenotype seen in several members of this highly consanguineous family included petechial rash, mild epistaxis and thrombocytopenia with some decrease in platelet volume. These clinical findings, together with the results of exome sequencing pointed to only one strong candidate gene, the FYB gene.
ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.
ADAP and Nck (show NCK1 ELISA Kits) adapter proteins cooperatively facilitate T cell adhesion to the LFA-1 (show ITGAL ELISA Kits) ligand ICAM-1 (show ICAM1 ELISA Kits).
These findings indicate that ADAP regulates two steps of HIV-1 infection cooperatively with two distinct receptors, and as such, serves as a new potential target in the blockade of HIV-1 infection.
ADAP (show APP ELISA Kits) fulfills different functions in CD4 (show CD4 ELISA Kits)(+) and CD8 (show CD8A ELISA Kits)(+) T cells, with CD8 (show CD8A ELISA Kits)(+) T cells being less dependent on ADAP (show APP ELISA Kits).
ADAP (show APP ELISA Kits) regulates CD8 (show CD8A ELISA Kits) T cell differentiation events following acute pathogen challenge that are critical for the formation and selected functions of TRM cells in nonlymphoid tissues.
Data (including data from studies in knockout/transgenic mice) suggest that ADAP (show APP ELISA Kits) regulates positive feedback loop of TGFbeta1 (show TGFB1 ELISA Kits) production and TGFbeta1 (show TGFB1 ELISA Kits)-induced CD103 (show ITGAE ELISA Kits) expression in CD8 (show CD8A ELISA Kits)+ T-lymphocytes and protects against influenza H5N1 virus infection.
The results indicate that ADAP (show APP ELISA Kits) dampens naive CD8 (show CD8A ELISA Kits) T cell responses to lymphopenia and IL-15 (show IL15 ELISA Kits), and they demonstrate a novel Ag-independent function for ADAP (show APP ELISA Kits) in the suppression of memory phenotype CD8 (show CD8A ELISA Kits) T cell generation.
provide evidence that CD28 (show CD28 ELISA Kits) and the TCR complex regulate NF-kappaB (show NFKB1 ELISA Kits) via different signaling modules of GRB-2 (show GRB2 ELISA Kits)/VAV1 (show VAV1 ELISA Kits) and LAT (show LAT ELISA Kits)/ADAP (show APP ELISA Kits) pathways respectively.
we demonstrate that loss of ADAP (show APP ELISA Kits) promotes resistance of experimental autoimmune encephalomyelitis in mice, likely by trapping encephalitogenic T cells in the peripheral lymph nodes on LYVE-1 (show LYVE1 ELISA Kits)+ lymphatic structures.
Signaling by Fyn (show FYN ELISA Kits)-ADAP (show APP ELISA Kits) via the Carma1 (show CARD11 ELISA Kits)-Bcl-10 (show BCL10 ELISA Kits)-MAP3K7 (show MAP3K7 ELISA Kits) signalosome exclusively regulates inflammatory cytokine production in NK cells.
integrin activation by the ADAP (show APP ELISA Kits)-SKAP55 (show SKAP1 ELISA Kits)-signaling module controls the stability and duration of T cell-dendritic cell contacts during the progressive phases necessary for optimal T cell activation.
ADAP (show APP ELISA Kits) coordinates distinct CARMA1 (show CARD11 ELISA Kits)-dependent control of key cell cycle proteins in T cells
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene.
, FYN-T-binding protein
, SLP-76-associated phosphoprotein
, adhesion and degranulation-promoting adaptor protein
, FYN binding protein FYB-130
, adhesion and degranulation promoting adaptor protein
, FYN binding protein (FYB-120/130)