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The aim of this study was to investigate the clinical significance of three immune cell-related transcription factors, T-bet, GATA-3 and Bcl-6 (show BCL6 ELISA Kits) in bladder cancer in Tunisian patients.
Data delineates the regulatory mechanisms of GATA3 in DNA double-strand breaks repair and strongly suggests that it might act as a tumor suppressor by promoting CtIP (show RBBP8 ELISA Kits) expression and homologous recombination to stabilize genomes.
data provide new insights into the role of SEMA3B (show SEMA3B ELISA Kits) in mammary gland and provides a new branch of GATA3 signaling that is pivotal for inhibition of breast cancer progression and metastasis
It gene expression is up-regulated by EP300 (show EP300 ELISA Kits)-ZNF384 (show ZNF384 ELISA Kits) fusion gene product.
Coexpression of GATA3 and CK7 (show KRT7 ELISA Kits) in most clear cell papillary renal cell carcinomas provides evidence of their origin from distal nephron and can be used in differential diagnosis.
Our findings suggest that GATA3 stabilizes HIF-1alpha (show HIF1A ELISA Kits) to enhance cancer invasiveness under hypoxia
GATA-3 is a sensitive and specific marker for the diagnosis of acute leukemias with T-cell differentiation.
In resected lung adenocarcinoma, high GATA3 expression is associated with poorer prognosis for both overall survival and disease free survival.
Loss of GATA3 expression was found to be an independent predictor of poor patient outcomes in bladder urothelial carcinoma.
Meta-analysis revealed that high expression of GATA3 in breast cancer is associated with improved time to tumor progression.
MIF (show MIF ELISA Kits)-deficient mice have reduced Nippostrongylus brasiliensis burden and mounted an enhanced type 2 immune response, including increased Gata3 expression and IL-13 (show IL13 ELISA Kits) production in the mesenteric lymph nodes
study demonstrates a role for HOX5 (show HOXB5 ELISA Kits) proteins in controlling lung inflammation during a model of allergic asthma. The increased inflammation in the Hox5 (show HOXB5 ELISA Kits)-deficient mice was mediated by increased Th2 cell development, which was associated with regulation of Gata3 expression
Treg cell accumulation in intestinal tumours from APC (show APC ELISA Kits)(min/+) mice was exclusively due to the increase in KLRG1 (show KLRG1 ELISA Kits)(+) GATA3(+) Treg cells.
GATA3 abundance regulates the recombination propensity at the Tcrb locus.
impairment of trophoblast-specific GATA2 (show GATA2 ELISA Kits)/GATA3 function could lead to early pregnancy failure
both Gata2 (show GATA2 ELISA Kits) and Gata3 are redundantly required for differentiation of the serotonergic and glutamatergic neurons of the dorsal raphe
priming of T helper cells by IL-6 (show IL6 ELISA Kits)-deficient antigen-presenting dendritic cells preferentially leads to accumulation of a subset of Follicular helper T cells characterized by high expression of GATA3 and IL-4 (show IL4 ELISA Kits).
Gata3 was first expressed in all developing neurons, followed by a decrease in type I primary auditory neurons as they matured.
Mediated by GATA3 through targeting promoter region of ORMDL3 (show ORMDL3 ELISA Kits).
these results indicate that picroside II has protective effects on allergic asthma by reducing GATA3 expression and Th2 cytokine bias.
gata3 acts as a specific injury-induced proregenerative factor that is essential for the regenerative capacity in vertebrates
GATA2 (show GATA2 ELISA Kits) and/or GATA3 are involved in the regulation of trophoblast-specific gene transcription in bovine trophoblast CT-1 (show SLC6A8 ELISA Kits) cells
study identified rainbow trout and Atlantic salmon IL-4 (show IL4 ELISA Kits)/13A, a homologue of mammalian Th2 cytokine genes IL-4 (show IL4 ELISA Kits) and IL-13 (show IL13 ELISA Kits); salmonid IL-4 (show IL4 ELISA Kits)/13A and GATA-3 were found highly expressed in thymus, gill, and skin
T cells expressed low levels of GATA-3, which decreased with age.
The myocardial immune dysfunction induced by the change in expression levels of the transcription factors GATA-3 and T-bet may be involved in the process of post-resuscitation myocardial injury in a porcine model of cardiac arrest.
Pig GATA-3 cDNA was obtained by reverse transcription polymerase chain reaction (RT-PCR), using in silico cloning strategy based on pig dbEST (show BEST1 ELISA Kits).
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia.
GATA-binding factor 3
, trans-acting T-cell-specific transcription factor GATA-3
, GATA-binding protein 3
, transcription factor GATA-3
, GATA binding factor-3
, transcription factor xGATA-3
, transcription factor NF-E1c
, GATA binding protein 3
, putative amidase
, trans-acting T-cell-specific transcription factor GATA-3-like