Browse our anti-GRAP2 (GRAP2) Antibodies

Full name:
anti-GRB2-Related Adaptor Protein 2 Antibodies (GRAP2)
On are 128 GRB2-Related Adaptor Protein 2 (GRAP2) Antibodies from 25 different suppliers available. Additionally we are shipping GRAP2 Proteins (14) and GRAP2 Kits (9) and many more products for this protein. A total of 164 GRAP2 products are currently listed.
Gads, GRAP-2, grap2, GRB2L, GRBLG, GrbX, Grf40, GRID, GrpL, Mona, P38, zgc:112091
list all antibodies Gene Name GeneID UniProt
GRAP2 9402 O75791
GRAP2 17444 O89100
GRAP2 366962  

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anti-Human GRAP2 Antibodies:

anti-Mouse (Murine) GRAP2 Antibodies:

anti-Rat (Rattus) GRAP2 Antibodies:

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Top referenced anti-GRAP2 Antibodies

  1. Human Monoclonal GRAP2 Primary Antibody for FACS, IP - ABIN567995 : Moran, Roessle, Mariuzza, Dimasi: Structural features of the full-length adaptor protein GADS in solution determined using small-angle X-ray scattering. in Biophysical journal 2008 (PubMed)
    Show all 7 references for 567995

  2. Human Polyclonal GRAP2 Primary Antibody for EIA, WB - ABIN952624 : Segat, Milanese, Pirulli, Trevisiol, Lupo, Salizzoni, Amoroso, Crovella: Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients. in Journal of gastroenterology and hepatology 2009 (PubMed)
    Show all 5 references for 952624

  3. Human Polyclonal GRAP2 Primary Antibody for ELISA, WB - ABIN184603 : Qiu, Hua, Agrawal, Li, Cai, Chan, Zhou, Luo, Liu: Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1. in Biochemical and biophysical research communications 1999 (PubMed)

More Antibodies against GRAP2 Interaction Partners

Human GRB2-Related Adaptor Protein 2 (GRAP2) interaction partners

  1. These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 (show LCP2 Antibodies) complex is required for costimulation by CD6 (show CD6 Antibodies).

  2. Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2 (show GRB2 Antibodies)), Grb2 (show GRB2 Antibodies)-related adaptor downstream of Shc (show SHC1 Antibodies) (Gads), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src (show SRC Antibodies) homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 (show CD28 Antibodies) with variable affinity

  3. GADS deficient T cells displayed similar levels of T cell receptor -induced SLP-76 (show LCP2 Antibodies) and PLC-gamma1 (show PLCG1 Antibodies) phosphorylation but exhibited substantial decrease in TCR-induced IL-2 (show IL2 Antibodies) and IFN-gamma (show IFNG Antibodies) release.

  4. Gads was dispensable for TCR-induced phosphorylation of SLP-76 (show LCP2 Antibodies), but was a dose-dependent amplifier of TCR-induced CD69 (show CD69 Antibodies) expression.

  5. GADS mediates lymphoid disease downstream of BCR-ABL (show ABL1 Antibodies) through the recruitment of specific signaling intermediates.

  6. Histidine domain-protein tyrosine phosphatase (show ACP1 Antibodies) interacts with Grb2 (show GRB2 Antibodies) and GrpL

  7. The results show that Bcr-Abl (show ABL1 Antibodies) regulates the actin cytoskeleton and non-apoptotic membrane blebbing via a GADS/Slp-76 (show LCP2 Antibodies)/Nck1 (show NCK1 Antibodies) adaptor protein pathway.

  8. Exogenous expression of GrpL in a GrpL-negative B cell line leads to enhanced antigen receptor-induced extracellular signal-related kinase and p38 mitogen-activated protein kinase (show MAPK14 Antibodies) phosphorylation.

  9. AML-1 (show RUNX1 Antibodies) plays a role in driving Mona (show MMP2 Antibodies) protein expression in T and myelomonocytic cells.

  10. Plays a tissue-specific role as an inhibitor of RET receptor tyrosine kinase (show RET Antibodies) mitogenic signaling

Mouse (Murine) GRB2-Related Adaptor Protein 2 (GRAP2) interaction partners

  1. The combined loss of Gads and CD127 (show IL7R Antibodies) reveals a novel function of Gads prior to T cell receptor beta expression

  2. GADS mediates lymphoid disease downstream of BCR-ABL (show ABL1 Antibodies) through the recruitment of specific signaling intermediates.

  3. Data show that the primary function of Gads is to regulate the sensitivity of the TCR to Ag ligation.

  4. Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein (show GAB3 Antibodies) during monocyte/macrophage differentiation. (Gab3 scaffolding protein (show GAB3 Antibodies))

  5. Results reveal the basis for preferential recognition of specific LAT (show LAT Antibodies) sites by Gads.

  6. Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1 (show MAP4K1 Antibodies)) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix

  7. The Gads adaptor protein is critical for homeostasis of CD4 (show CD4 Antibodies)(+) T cells.

  8. Selective impairment of FcepsilonRI (show FCER1A Antibodies)-mediated allergic reaction in Gads-deficient mice

  9. Gads plays a key role in linking the adapter LAT (show LAT Antibodies) to SLP-76 (show LCP2 Antibodies) in response to weak activation of GPVI (show GP6 Antibodies) and CLEC-2 (show CLEC1B Antibodies) whereas LAT (show LAT Antibodies) is required for full activation over a wider range of agonist concentrations.

GRAP2 Antigen Profile

Antigen Summary

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.

Alternative names and synonyms associated with GRAP2

  • GRB2-related adaptor protein 2a (grap2a) antibody
  • GRB2-related adaptor protein 2 (GRAP2) antibody
  • GRB2-related adaptor protein 2 (grap2) antibody
  • GRB2-related adaptor protein 2 (Grap2) antibody
  • Gads antibody
  • GRAP-2 antibody
  • grap2 antibody
  • GRB2L antibody
  • GRBLG antibody
  • GrbX antibody
  • Grf40 antibody
  • GRID antibody
  • GrpL antibody
  • Mona antibody
  • P38 antibody
  • zgc:112091 antibody

Protein level used designations for GRAP2

GRB2-related adaptor protein 2 , GRB2-related adapter protein 2 , GRB-2-like protein , GRB2-related protein with insert domain , SH3-SH2-SH3 adapter Mona , SH3-SH2-SH3 adaptor molecule , adapter protein GRID , grf-40 , grf40 adapter protein , growth factor receptor-binding protein , growth factor receptor-bound protein 2-related adaptor protein 2 , hematopoietic cell-associated adapter protein GrpL , hematopoietic cell-associated adaptor protein GRPL , GRB-2-related monocytic adapter protein , GRBLG , Grb2-related adaptor downstream of Sch , hematopoietic cell-associated adaptor protein GrpL , monocytic adapter , monocytic adaptor

550452 Danio rerio
704410 Macaca mulatta
744653 Pan troglodytes
770756 Gallus gallus
100195406 Salmo salar
100589837 Nomascus leucogenys
9402 Homo sapiens
17444 Mus musculus
366962 Rattus norvegicus
481241 Canis lupus familiaris
522346 Bos taurus
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