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anti-Human HLA-DRB1 Antibodies:
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Human Polyclonal HLA-DRB1 Primary Antibody for WB - ABIN1944757
Tonnelle, DeMars, Long: DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression. in The EMBO journal 1986
Show all 5 Pubmed References
Human Polyclonal HLA-DRB1 Primary Antibody for WB - ABIN516510
Cao, Schmitz, Yang, Hogan, Bunch, Hu, Jennette, Berg, Arnett, Jennette, Falk, Preston: DRB1*15 allele is a risk factor for PR3-ANCA disease in African Americans. in Journal of the American Society of Nephrology : JASN 2011
HLA susceptibility alleles in Norwegian juvenile MG where HLA-DRB1*04:04 was associated with prepubertal onset
Anticitrullinated peptide antibody-positive rheumatoid arthritis (RA) in Indigenous North American populations was independently associated with HLA-DRB1*14:02. HLA-DRB1*14:02-vimentin59-71-specific and HLA-DRB1*14:02-vimentin (show VIM Antibodies)-64Cit59-71-specific CD4 (show CD4 Antibodies)+ memory T cells were phenotypically distinct populations.
The authors identified alpha3128-142 (DIPPCPHGWISLWKG) as the core binding motif of P14 (show S100A9 Antibodies) to HLA-DRB1*1501 molecule. And the critical amino acid residues for this binding were further defined as C132, W 136, K 141, and G 142.
Living at a higher latitude and carrying the DRB1 (show RBM45 Antibodies)*04:05 allele independently lessens severity in patient with multiple sclerosis in japan.
MPO (show MPO Antibodies) complexed with HLA class II molecules is involved in the pathogenesis of MPA as a target for MPO (show MPO Antibodies)-ANCA.
this study proposes a mechanism for HLA-DRB1*1501 susceptibility for Goodpasture's disease in Chinese patients
This study has demonstrated strong association of major histocompatibility complex haplotypes with increased and reduced risk of HPV-associated cervical cancers, with findings implicating both HLA Class I and Class II loci. These associations are driven by the identity of amino-acids at positions 13 and 71 in HLA-DRB1 and 156 in HLA-B.
Although predominant associations with the HLA-DRB1 locus have been known for decades, recent data have revealed additional insight into the likely causative variants within HLA-DRB1 as well as within other HLA loci that contribute to disease risk. In addition, more than 100 common variants in non-HLA loci have been implicated in disease susceptibility
This study revevled that The HLA-DRB1*03:01 allele was associated with neuromyelitis optica regardless the neuromyelitis optica -IgG status but did not influence the long term disability.
There was an increased risk of rheumatoid arthritis among mothers who had any child with shared epitope, DERAA, or valine, lysine and alanine at DRB1 (show RBM45 Antibodies) positions 11, 71 and 74, respectively.
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide\; exons 2 and 3 encode the two extracellular domains\; exon 4 encodes the transmembrane domain\; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
major histocompatibility complex, class II, DR beta 1
, HLA class II histocompatibility antigen, DR-1 beta chain
, MHC class II HLA-DR beta 1 chain
, MHC class II HLA-DR-beta cell surface glycoprotein
, MHC class II HLA-DRw10-beta
, MHC class II antigen
, human leucocyte antigen DRB1
, lymphocyte antigen DRB1