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anti-Human HLA-DRB1 Antibodies:
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Human Polyclonal HLA-DRB1 Primary Antibody for WB - ABIN1944757
Tonnelle, DeMars, Long: DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression. in The EMBO journal 1986
Show all 5 Pubmed References
Human Polyclonal HLA-DRB1 Primary Antibody for WB - ABIN516510
Cao, Schmitz, Yang, Hogan, Bunch, Hu, Jennette, Berg, Arnett, Jennette, Falk, Preston: DRB1*15 allele is a risk factor for PR3-ANCA disease in African Americans. in Journal of the American Society of Nephrology : JASN 2011
Systemic sclerosis patients differed from controls when DRB1 (show RBM45 Antibodies) alleles were categorized according to 3rd hypervariable region sequences
these findings support the hypothesis that exposure to the fetus influences a mother's risk of disease. This is the first study to demonstrate an association between a child's DRB1 (show RBM45 Antibodies) genotype and risk of SLE in the mother.
this study supports a role for HLA-DRB1 alleles as genetic risk factors of IgE-mediated peanut allergy.
these results confirm an association of HLA-DRB1 alleles and haplotypes with polycystic ovary syndrome susceptibility in Bahraini
Genetically, the strong primary sclerosing cholangitis (PSC) risk factors HLA-B*08 and DRB1 (show RBM45 Antibodies)*03 were more prevalent in Antineutrophil cytoplasmic antibodies (ANCA) -positive than -negative patients. In UC patients without liver disease, HLA-DRB1*03 was more prevalent in pANCA-positive compared with -negative patients.Antineutrophil cytoplasmic antibodies identified PSC patients with clinical and genetic characteristics.
HLA-DRB1*08:03:02 and HLA-DQB1 (show HLA-DQB1 Antibodies)*06:01:01 are associated with house dust mites (HMD)-sensitive AR and may confer a risk for development of allergic rhinitis in Han Chinese subjects sensitized to HDM (show HDAC3 Antibodies).
The DRB1 (show RBM45 Antibodies)*04:02 allele was associated with pemphigus vulgaris (show DSG3 Antibodies) in our study as well as in various populations. The association with HLA-DRB1*08:04 in our study was confirmed to be specific to this allele and not to linkage disequilibrium to any adjacent gene.
The autoantibody and HLA profiles of Somali children with diabetes are consistent with autoimmune diabetes. Their HLA profile is unique with an exceptionally high prevalence of DRB1 (show RBM45 Antibodies)*03:01 allele and relative paucity of DR4 (show HLADRB4 Antibodies) alleles compared with African Americans with T1 diabetes.
frequencies of HLA-DRB1*03:01 (pc = 0.0378, OR = 4.8) and HLA-DQB1 (show HLA-DQB1 Antibodies)*02:01 (pc = 0.021, OR = 4.8) alleles were significantly higher in patients with JORRP than in controls. In addition, HLA-DRB1*03:01 allele significantly correlated with aggressive JORRP
association of DR4/DR8 heterozygous genotype suggested the pathologic importance of trans-complementing DQalpha-beta heterodimer molecules encoded by DQA1 allele of one haplotype and the DQB1 allele of the other haplotype, as it was proposed in the HLA association studies of Type 1 diabetes
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide\; exons 2 and 3 encode the two extracellular domains\; exon 4 encodes the transmembrane domain\; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
major histocompatibility complex, class II, DR beta 1
, HLA class II histocompatibility antigen, DR-1 beta chain
, MHC class II HLA-DR beta 1 chain
, MHC class II HLA-DR-beta cell surface glycoprotein
, MHC class II HLA-DRw10-beta
, MHC class II antigen
, human leucocyte antigen DRB1
, lymphocyte antigen DRB1