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HLA Class II DR beta 1 ELISA Kits (HLA-DRB1)
On are 8 HLA Class II DR beta 1 (HLA-DRB1) ELISA Kits from 4 different suppliers available. Additionally we are shipping HLA-DRB1 Antibodies (211) and HLA-DRB1 Proteins (26) and many more products for this protein. A total of 250 HLA-DRB1 products are currently listed.
DRB1, DRw10, HLA-DR1B, HLA-DRB, MGC108235, SS1
list all ELISA KIts Gene Name GeneID UniProt
HLA-DRB1 3123 P01912 , P01911 , Q29974

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Human HLA Class II DR beta 1 (HLA-DRB1) interaction partners

  1. The authors identified alpha3128-142 (DIPPCPHGWISLWKG) as the core binding motif of P14 (show S100A9 ELISA Kits) to HLA-DRB1*1501 molecule. And the critical amino acid residues for this binding were further defined as C132, W 136, K 141, and G 142.

  2. Living at a higher latitude and carrying the DRB1*04:05 allele independently lessens severity in patient with multiple sclerosis in japan.

  3. MPO (show MPO ELISA Kits) complexed with HLA class II molecules is involved in the pathogenesis of MPA as a target for MPO (show MPO ELISA Kits)-ANCA.

  4. this study proposes a mechanism for HLA-DRB1*1501 susceptibility for Goodpasture's disease in Chinese patients

  5. This study has demonstrated strong association of major histocompatibility complex haplotypes with increased and reduced risk of HPV-associated cervical cancers, with findings implicating both HLA Class I and Class II loci. These associations are driven by the identity of amino-acids at positions 13 and 71 in HLA-DRB1 and 156 in HLA-B.

  6. Although predominant associations with the HLA-DRB1 locus have been known for decades, recent data have revealed additional insight into the likely causative variants within HLA-DRB1 as well as within other HLA loci that contribute to disease risk. In addition, more than 100 common variants in non-HLA loci have been implicated in disease susceptibility

  7. This study revevled that The HLA-DRB1*03:01 allele was associated with neuromyelitis optica regardless the neuromyelitis optica -IgG status but did not influence the long term disability.

  8. There was an increased risk of rheumatoid arthritis among mothers who had any child with shared epitope, DERAA, or valine, lysine and alanine at DRB1 positions 11, 71 and 74, respectively.

  9. Variation at HLA-DRB1 was associated with rheumatoid arthritis in an Arab population.

  10. HLA-DRB1*03:01, DRB1*01:01, and DRB1*13:01 were associated with risk of sporadic inclusion body myositis.

HLA-DRB1 Antigen Profile

Antigen Summary

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide\; exons 2 and 3 encode the two extracellular domains\; exon 4 encodes the transmembrane domain\; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Alternative names and synonyms associated with HLA-DRB1

  • major histocompatibility complex, class II, DR beta 1 (hla-drb1) Elisa Kit
  • major histocompatibility complex, class II, DR beta 1 (HLA-DRB1) Elisa Kit
  • DRB1 Elisa Kit
  • DRw10 Elisa Kit
  • HLA-DR1B Elisa Kit
  • HLA-DRB Elisa Kit
  • MGC108235 Elisa Kit
  • SS1 Elisa Kit

Protein level used designations for HLA-DRB1

major histocompatibility complex, class II, DR beta 1 , DW2.2/DR2.2 , HLA class II histocompatibility antigen, DR-1 beta chain , MHC class II HLA-DR beta 1 chain , MHC class II HLA-DR-beta cell surface glycoprotein , MHC class II HLA-DRw10-beta , MHC class II antigen , human leucocyte antigen DRB1 , lymphocyte antigen DRB1

734125 Xenopus (Silurana) tropicalis
3123 Homo sapiens
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