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anti-Human PSTPIP1 Antibodies:
anti-Mouse (Murine) PSTPIP1 Antibodies:
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Human Polyclonal PSTPIP1 Primary Antibody for EIA, WB - ABIN954360
André, Aumaître, Grateau, Chamaillard, Costedoat-Chalumeau, Cardoso, Henry-Berger, Ramakrishna, Delpech, Piette, Creveaux: Longest form of CCTG microsatellite repeat in the promoter of the CD2BP1/PSTPIP1 gene is associated with aseptic abscesses and with Crohn disease in French patients. in Digestive diseases and sciences 2010
Molecular interactions between HPIP and FAK (show PTK2 Antibodies), and HPIP and calpain2 regulate cell adhesion and migration through modulation of focal adhesion dynamics.
Case Report: missense mutation in PSTPIP1, the gene responsible for PAPA (show PAPPA Antibodies) syndrome.
we have shown that PSTPIP1 regulates T-cell activation upon CD3 and CD28 stimulation, independently of CD2 costimulation. PSTPIP1 acts downstream of proximal TCR signaling, inhibiting several transcription factors.
PSTPIP1 has a role in the pathogenesis of pyoderma gangrenosum through filopodia formation resulting in extracellular matrix degradation
novel mutaations found in PSTPIP1 gene in patients with pyoderma gangrenosum
The CCTG (show CCT3 Antibodies) repeat in the PSTPIP1 promoter may play a role in the pathogenesis of aseptic abscess syndrome and Crohn's disease.
CD2BP1-mediated biochemical pathway(s) may function in common inflammatory disorders with apparent etiological overlap, such as rheumatoid arthritis and inflammatory bowel disease
PSTPIP1 acts downstream of CD2/CD2AP to link CD2 engagement to the WASp-evoked actin polymerization required for synapse formation and T cell activation.
PSTPIP1/CD2BP1 protein binds to pyrin (show MEFV Antibodies)
the intracellular Fas ligand (FasL (show FASL Antibodies)) domain binding to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL (show FASL Antibodies)
analysis of inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA (show PAPPA Antibodies)) Syndrome-associated PSTPIP1 A230T mutant proteins
PSTPIP1 is a novel component of the leukocyte uropod that regulates endocytosis and cell migration
The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome.
proline-serine-threonine phosphatase interacting protein 1
, proline-serine-threonine phosphatase-interacting protein 1
, CD2 antigen-binding protein 1
, CD2 cytoplasmic tail-binding protein
, CD2-binding protein 1
, PEST phosphatase-interacting protein 1