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PSTPIP1 antibody (AA 157-416)

PSTPIP1 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7164772
  • Target See all PSTPIP1 Antibodies
    PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))
    Binding Specificity
    • 11
    • 9
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 157-416
    Reactivity
    • 25
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 23
    • 2
    Rabbit
    Clonality
    • 23
    • 2
    Polyclonal
    Conjugate
    • 14
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This PSTPIP1 antibody is un-conjugated
    Application
    • 25
    • 18
    • 14
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human, Mouse
    Purification
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Proline-serine-threonine phosphatase-interacting protein 1 protein (157-416AA)
    Isotype
    IgG
  • Application Notes
    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))
    Alternative Name
    PSTPIP1 (PSTPIP1 Products)
    Synonyms
    cd2bp1 antibody, cd2bp1l antibody, cd2bp1s antibody, h-pip antibody, papas antibody, pstpip antibody, PSTPIP1 antibody, CD2BP1 antibody, CD2BP1L antibody, CD2BP1S antibody, H-PIP antibody, PAPAS antibody, PSTPIP antibody, def-2 antibody, proline-serine-threonine phosphatase interacting protein 1 antibody, proline-serine-threonine phosphatase interacting protein 1 S homeolog antibody, proline-serine-threonine phosphatase-interacting protein 1 antibody, PSTPIP1 antibody, pstpip1.S antibody, pstpip1 antibody, Pstpip1 antibody
    Background

    Background: Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.

    Aliases: CD2 antigen binding protein 1 antibody, CD2 binding protein 1 antibody, CD2 cytoplasmic tail binding protein antibody, CD2-binding protein 1 antibody, CD2BP1 antibody, CD2BP1L antibody, CD2BP1S antibody, H PIP antibody, H-PIP antibody, HPIP antibody, PAPAS antibody, PEST phosphatase interacting protein 1 antibody, PEST phosphatase-interacting protein 1 antibody, PPIP1_HUMAN antibody, Proline serine threonine phosphatase interacting protein 1 antibody, Proline-serine-threonine phosphatase-interacting protein 1 antibody, PSTPIP antibody, Pstpip1 antibody

    UniProt
    O43586
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