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Browse our PTK2B Proteins (PTK2B)

Full name:
PTK2B Protein tyrosine Kinase 2 beta Proteins (PTK2B)
On www.antibodies-online.com are 11 PTK2B Protein tyrosine Kinase 2 beta (PTK2B) Proteins from 7 different suppliers available. Additionally we are shipping PTK2B Antibodies (243) and PTK2B Kits (20) and many more products for this protein. A total of 292 PTK2B products are currently listed.
Synonyms:
Akt, CADTK, CAKB, CAKbeta, E430023O05Rik, FADK2, FAK2, PKB, PKB/Akt, PKBalpha, PTK, Pyk2, Rac, Raftk
list all proteins Gene Name GeneID UniProt
PTK2B 24185 P47196
PTK2B 11651 P31750
PTK2B 2185 Q14289

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PTK2B Proteins (PTK2B) by Origin

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More Proteins for PTK2B Interaction Partners

Mouse (Murine) PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. A cell-culture study using an inhibitor of estrogen receptors and an in vivo experiment with ovariectomized mice suggested that the estrogenic activity of 8-PN contributed to recovery from disuse muscle atrophy through activation of an Akt (show AKT1 Proteins) phosphorylation pathway. These data strongly suggest that 8-PN is a naturally occurring compound that could be used as a nutritional supplement to aid recovery from disuse muscle atroph

  2. Analysis of the successful model also elucidates two dynamical motifs: neutralization of a negative regulator, which characterizes how Akt (show AKT1 Proteins) indirectly activates mTORC1, and seesaw enzyme regulation, which describes how activated and inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response

  3. Data show that Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) and MAPK (show MAPK1 Proteins) pathways were activated in ovine pulmonary adenocarcinoma (OPA) lung and envelope (Env (show ERVW-1 Proteins)) of Jaagsiekte sheep retrovirus (JSRV) transfected NIH 3T3 cells.

  4. Results suggest that SC79 compound activates Akt (show AKT1 Proteins)-Nrf2 (show NFE2L2 Proteins) signaling to protect osteoblasts from dexamethasone (Dex).

  5. In conclusion, we have identified that ARL15 acts as an insulin (show INS Proteins)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (show IRS1 Proteins)/PDPK1 (show PDPK1 Proteins)/AKT (show AKT1 Proteins) insulin (show INS Proteins) pathway by interacting with its GAP ASAP2 (show ASAP2 Proteins) and activating PDPK1 (show PDPK1 Proteins). This research may provide new insights into GTPase (show RACGAP1 Proteins)-mediated insulin (show INS Proteins) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS Proteins) sensitizati

  6. Taken together, our findings imply that KLF15 possesses potential anti-hypertrophic and anti-fibrotic functions, possibly via regulation of cell death pathways and the inhibition of Akt/mTOR axis. KLF15 may constitute an efficient candidate drug for the treatment of heart failure and other cardiovascular diseases.

  7. Menin (show MEN1 Proteins) binds on the promoter of Inhbb (show INHBB Proteins) gene where it favours the recruitment of Ezh2 (show EZH2 Proteins) via an indirect mechanism involving Akt (show AKT1 Proteins)-phosphorylation.

  8. A role of AKT (show AKT1 Proteins) in the regulatory T cell differentiation process. TGF-beta (show TGFB1 Proteins) induces the phosphorylation of Akt (show AKT1 Proteins) in CD4 (show CD4 Proteins)+ T cells.

  9. 4-PBA reverses autophagic dysfunction and improves insulin (show INS Proteins) sensitivity in adipose tissue of obese mice via Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling partly, which could be regarded as novel opportunities for treatment of insulin (show INS Proteins) resistance.

  10. These studies reveal a novel mechanism in which CYP2J2 (show CYP2J2 Proteins) and epoxyeicosatrienoic acids enhanced Akt1 (show AKT1 Proteins) nuclear translocation through interaction with AMPKalpha2beta2gamma1 and protect against cardiac hypertrophy.

Human PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin, a process in part mediated through the PI3-kinase (show PIK3CA Proteins)-Akt/PKB (show AKT1 Proteins) cell survival pathway. These results provide further rationale for clinical investigation of relaxin as a potential therapeutic in preeclampsia.

  2. PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.

  3. Studies suggest that PYK2 is a common downstream effector of ErbB (show EGFR Proteins) and IL8 (show IL8 Proteins) receptors, and that PYK2 integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.

  4. Pyk2 is a key downstream signaling molecules of CCR7 (show CCR7 Proteins) in SCCHN, which promotes SCCHN tumorigenesis and progression.

  5. Phosphoproteomic analysis identifies FAK2 as a potential therapeutic target for tamoxifen resistance in breast cancer.

  6. Pyk2-focal adhesion targeting domain interacts with and binds to leupaxin (show LPXN Proteins).

  7. Src (show SRC Proteins) has a role in priming Pyk2 (but not FAK (show PTK2 Proteins)) phosphorylation and subsequent activation downstream of integrins

  8. Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.

  9. FAK (show PTK2 Proteins) and PYK2 functioned redundantly to promote the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway by phosphorylating GSK3beta(Y216) to reinforce pathway output-beta-catenin (show CTNNB1 Proteins) accumulation and intestinal tumorigenesis.

  10. This study identified Pyk2 as a cellular component required for the intracellular trafficking of HPV16 during infection.

Cow (Bovine) PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]

PTK2B Protein Profile

Protein Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with PTK2B

  • v-akt murine thymoma viral oncogene homolog 1 (Akt1)
  • thymoma viral proto-oncogene 1 (Akt1)
  • protein tyrosine kinase 2 beta (PTK2B)
  • protein tyrosine kinase 2 beta (Ptk2b)
  • PTK2 protein tyrosine kinase 2 beta (Ptk2b)
  • PTK2B protein tyrosine kinase 2 beta (PTK2B)
  • Akt protein
  • CADTK protein
  • CAKB protein
  • CAKbeta protein
  • E430023O05Rik protein
  • FADK2 protein
  • FAK2 protein
  • PKB protein
  • PKB/Akt protein
  • PKBalpha protein
  • PTK protein
  • Pyk2 protein
  • Rac protein
  • Raftk protein

Protein level used designations for PTK2B

AKT1 kinase , PKB alpha , RAC protein kinase alpha RAC-PK alpha , RAC-PK-alpha , RAC-alpha serine/threonine-protein kinase , murine thymoma viral (v-akt) oncogene homolog 1 , protein kinase B alpha , thymoma viral proto-oncogene 1 , protein kinase B-alpha , proto-oncogene c-AKT , related to A and C kinases , CAK-beta , FADK 2 , PTK2B protein tyrosine kinase 2 beta , calcium-dependent tyrosine kinase , calcium-regulated non-receptor proline-rich tyrosine kinase , cell adhesion kinase beta , focal adhesion kinase 2 , proline-rich tyrosine kinase 2 , protein kinase B , protein-tyrosine kinase 2-beta , related adhesion focal tyrosine kinase , CADTK , CAK beta , PTK2 protein tyrosine kinase 2 beta , cellular adhesion kinase beta , protein tyrosine kinase 2 beta

GENE ID SPECIES
24185 Rattus norvegicus
11651 Mus musculus
2185 Homo sapiens
50646 Rattus norvegicus
19229 Mus musculus
486102 Canis lupus familiaris
541008 Bos taurus
421998 Gallus gallus
100157507 Sus scrofa
100342358 Oryctolagus cuniculus
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