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Browse our PTK2B Proteins (PTK2B)

Full name:
PTK2B Protein tyrosine Kinase 2 beta Proteins (PTK2B)
On www.antibodies-online.com are 9 PTK2B Protein tyrosine Kinase 2 beta (PTK2B) Proteins from 5 different suppliers available. Additionally we are shipping PTK2B Antibodies (245) and PTK2B Kits (17) and many more products for this protein. A total of 288 PTK2B products are currently listed.
Synonyms:
Akt, CADTK, CAKB, CAKbeta, E430023O05Rik, FADK2, FAK2, PKB, PKB/Akt, PKBalpha, PTK, Pyk2, Rac, Raftk
list all proteins Gene Name GeneID UniProt
PTK2B 24185 P47196
PTK2B 11651 P31750
PTK2B 2185 Q14289

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PTK2B Proteins (PTK2B) by Origin

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More Proteins for PTK2B Interaction Partners

Mouse (Murine) PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. Ambient fine particulate matter-induced myocarditis is mediated by EGFR (show EGFR Proteins)/Akt (show AKT1 Proteins) signaling and overexpression of NLRP3 (show NLRP3 Proteins) and NLRP12 (show NLRP12 Proteins).

  2. GSK3b may up-regulate BK channels, an effect disrupted by lithium or additional expression of AKT (show AKT1 Proteins) and possibly participating in the regulation of cell volume and excitability.

  3. Akt1 regulates cell division and F-actin rearrangement in mouse fertilized eggs.

  4. The results suggest that KCa3.1 (show KCNN4 Proteins) activation contributes to dysfunctional tubular autophagy in diabetic nephropathy through PI3K/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling pathways.

  5. These results reveal a key role of the AKT (show AKT1 Proteins)-GSK3beta-eIF2Bepsilon (show EIF2B5 Proteins) signaling module in regulating axon regeneration in the adult mammalian central nervous system.

  6. IL-4 (show IL4 Proteins) signaling co-opts the Akt (show AKT1 Proteins)-mTORC1 pathway to regulate Acly (show ACLY Proteins), a key enzyme in acetyl-CoA (show LPCAT1 Proteins) synthesis, leading to increased histone acetylation and macrophage gene induction.

  7. Data suggest that phosphorylated Ser473-Akt akt (show AKT1 Proteins) proto-oncogene (show RAB1A Proteins) protein may be a potential player in the major zygotic genome activation (ZGA) of 2-cell embryos.

  8. PI3K-Akt (show AKT1 Proteins)-Foxo1 (show FOXO1 Proteins) and mTORC1-mTORC2 (show CRTC2 Proteins) pathways differentially regulate endothelial cell elongation.

  9. suppression of AKT (show AKT1 Proteins) by hyperactivation of mTORC1, inhibition on nuclear ERalpha (show ESR1 Proteins) signaling, and down-regulation of cell-cycle-driving proteins play important roles in the retarded mammary development induced by Tsc1 (show TSC1 Proteins) deletion.

  10. results suggest that emodin inhibited apoptosis and autophagy in TNF-alpha (show TNF Proteins)-induced myoblasts through the activation of phosphorylated Akt (show AKT1 Proteins)

Human PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. Studies suggest that PYK2 is a common downstream effector of ErbB (show EGFR Proteins) and IL8 (show IL8 Proteins) receptors, and that PYK2 integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.

  2. Pyk2 is a key downstream signaling molecules of CCR7 (show CCR7 Proteins) in SCCHN, which promotes SCCHN tumorigenesis and progression.

  3. Phosphoproteomic analysis identifies FAK2 as a potential therapeutic target for tamoxifen resistance in breast cancer.

  4. Pyk2-focal adhesion targeting domain interacts with and binds to leupaxin (show LPXN Proteins).

  5. Src (show SRC Proteins) has a role in priming Pyk2 (but not FAK (show PTK2 Proteins)) phosphorylation and subsequent activation downstream of integrins

  6. Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.

  7. FAK (show PTK2 Proteins) and PYK2 functioned redundantly to promote the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway by phosphorylating GSK3beta(Y216) to reinforce pathway output-beta-catenin (show CTNNB1 Proteins) accumulation and intestinal tumorigenesis.

  8. This study identified Pyk2 as a cellular component required for the intracellular trafficking of HPV16 during infection.

  9. These results suggest that melatonin exerts anti-migratory and anti-invasive effects on glioma cells in response to hypoxia via reactive oxygen species-alphavbeta3 integrin-FAK (show PTK2 Proteins)/Pyk2 signaling pathways.

  10. data suggest a novel role for FAK (show PTK2 Proteins) in GPVI (show GP6 Proteins)-dependent ROS (show ROS1 Proteins) formation and platelet activation and elucidate a proximal signaling role for FAK (show PTK2 Proteins) within the GPVI (show GP6 Proteins) pathway.

Cow (Bovine) PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]

PTK2B Protein Profile

Protein Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with PTK2B

  • v-akt murine thymoma viral oncogene homolog 1 (Akt1)
  • thymoma viral proto-oncogene 1 (Akt1)
  • protein tyrosine kinase 2 beta (PTK2B)
  • protein tyrosine kinase 2 beta (Ptk2b)
  • PTK2 protein tyrosine kinase 2 beta (Ptk2b)
  • PTK2B protein tyrosine kinase 2 beta (PTK2B)
  • Akt protein
  • CADTK protein
  • CAKB protein
  • CAKbeta protein
  • E430023O05Rik protein
  • FADK2 protein
  • FAK2 protein
  • PKB protein
  • PKB/Akt protein
  • PKBalpha protein
  • PTK protein
  • Pyk2 protein
  • Rac protein
  • Raftk protein

Protein level used designations for PTK2B

AKT1 kinase , PKB alpha , RAC protein kinase alpha RAC-PK alpha , RAC-PK-alpha , RAC-alpha serine/threonine-protein kinase , murine thymoma viral (v-akt) oncogene homolog 1 , protein kinase B alpha , thymoma viral proto-oncogene 1 , protein kinase B-alpha , proto-oncogene c-AKT , related to A and C kinases , CAK-beta , FADK 2 , PTK2B protein tyrosine kinase 2 beta , calcium-dependent tyrosine kinase , calcium-regulated non-receptor proline-rich tyrosine kinase , cell adhesion kinase beta , focal adhesion kinase 2 , proline-rich tyrosine kinase 2 , protein kinase B , protein-tyrosine kinase 2-beta , related adhesion focal tyrosine kinase , CADTK , CAK beta , PTK2 protein tyrosine kinase 2 beta , cellular adhesion kinase beta , protein tyrosine kinase 2 beta

GENE ID SPECIES
24185 Rattus norvegicus
11651 Mus musculus
2185 Homo sapiens
50646 Rattus norvegicus
19229 Mus musculus
486102 Canis lupus familiaris
541008 Bos taurus
421998 Gallus gallus
100157507 Sus scrofa
100342358 Oryctolagus cuniculus
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