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Browse our PTK2B Proteins (PTK2B)

Full name:
PTK2B Protein tyrosine Kinase 2 beta Proteins (PTK2B)
On www.antibodies-online.com are 9 PTK2B Protein tyrosine Kinase 2 beta (PTK2B) Proteins from 5 different suppliers available. Additionally we are shipping PTK2B Antibodies (236) and PTK2B Kits (17) and many more products for this protein. A total of 279 PTK2B products are currently listed.
Synonyms:
Akt, CADTK, CAKB, CAKbeta, E430023O05Rik, FADK2, FAK2, PKB, PKB/Akt, PKBalpha, PTK, Pyk2, Rac, Raftk
list all proteins Gene Name GeneID UniProt
PTK2B 24185 P47196
PTK2B 11651 P31750
PTK2B 2185 Q14289

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PTK2B Proteins (PTK2B) by Origin

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More Proteins for PTK2B Interaction Partners

Mouse (Murine) PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. Endothelial Akt1 (show AKT1 Proteins) activation in ovarian grafts promoted angiogenesis to support the graft during posttransplantation hypoxic period

  2. Uncarboxylated osteocalcin (show BGLAP Proteins) inhibits high glucose-induced reactive oxygen species production and stimulates osteoblastic differentiation by inhibiting the activation of PI3K/Akt (show AKT1 Proteins) in MC3T3-E1 cells.

  3. miR-23b acts as a suppressor of epithelial-to-mesenchymal transition in diabetic nephropathy through repressing PI3K-AKT signaling pathway by targeting HMGA2 and thus alleviating the disease.

  4. PI3K/AKT (show AKT1 Proteins) pathway was partially involved in the modulation of the release HMGB-1 (show HMGB1 Proteins) from reactive astrocytes.

  5. These observations suggest that the antiinflammatory properties of crebanine may stem from the inhibition of proinflammatory mediators via suppression of the NF-kappaB (show NFKB1 Proteins), AP-1 (show JUN Proteins), MAPKs, and Akt (show AKT1 Proteins) signaling pathways.

  6. Data show that RNA silencing of CCN family member 1 (show CYR61 Proteins) protein (CCN1 (show CCNA2 Proteins)) inhibits retinal neovascularization (RNV) by inhibiting phosphoinositide 3-kinase (PI3K)/AKT (show AKT1 Proteins) protein signaling in mouse pup model of oxygen-induced retinopathy (OIR).

  7. rescued the hepatic regenerative capability in Akt1 (show AKT1 Proteins)-deficient and Akt2 (show AKT2 Proteins)-deficient mice

  8. While combined Akt1 and Akt3 deletion in adult mice is tolerated, combined Akt1 and Akt2 deletion induced rapid mortality involving glucose metabolism problems. ACT1-null mice are not resistant to diethylnitrosamine hepatocarcinogenesis.

  9. ShRNA knockdown (kd) of AKT1 (show AKT1 Proteins) prevents phosphorylation and subsequent degradation of nuclear lamins.

  10. Our study suggests that Ab25-35 induces autophagy and the PI3K/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins)/p70S6K (show RPS6KB1 Proteins) pathway is involved in the process, which improves our understanding of the pathogenesis of Alzheimer's disease and provides an additional model for AD research

Human PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. Studies suggest that PYK2 is a common downstream effector of ErbB (show EGFR Proteins) and IL8 (show IL8 Proteins) receptors, and that PYK2 integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.

  2. Pyk2 is a key downstream signaling molecules of CCR7 (show CCR7 Proteins) in SCCHN, which promotes SCCHN tumorigenesis and progression.

  3. Phosphoproteomic analysis identifies FAK2 as a potential therapeutic target for tamoxifen resistance in breast cancer.

  4. Pyk2-focal adhesion targeting domain interacts with and binds to leupaxin (show LPXN Proteins).

  5. Src (show SRC Proteins) has a role in priming Pyk2 (but not FAK (show PTK2 Proteins)) phosphorylation and subsequent activation downstream of integrins

  6. Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.

  7. FAK (show PTK2 Proteins) and PYK2 functioned redundantly to promote the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway by phosphorylating GSK3beta(Y216) to reinforce pathway output-beta-catenin (show CTNNB1 Proteins) accumulation and intestinal tumorigenesis.

  8. This study identified Pyk2 as a cellular component required for the intracellular trafficking of HPV16 during infection.

  9. These results suggest that melatonin exerts anti-migratory and anti-invasive effects on glioma cells in response to hypoxia via reactive oxygen species-alphavbeta3 integrin-FAK (show PTK2 Proteins)/Pyk2 signaling pathways.

  10. data suggest a novel role for FAK (show PTK2 Proteins) in GPVI (show GP6 Proteins)-dependent ROS (show ROS1 Proteins) formation and platelet activation and elucidate a proximal signaling role for FAK (show PTK2 Proteins) within the GPVI (show GP6 Proteins) pathway.

Cow (Bovine) PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]

PTK2B Protein Profile

Protein Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with PTK2B

  • v-akt murine thymoma viral oncogene homolog 1 (Akt1)
  • thymoma viral proto-oncogene 1 (Akt1)
  • protein tyrosine kinase 2 beta (PTK2B)
  • protein tyrosine kinase 2 beta (Ptk2b)
  • PTK2 protein tyrosine kinase 2 beta (Ptk2b)
  • PTK2B protein tyrosine kinase 2 beta (PTK2B)
  • Akt protein
  • CADTK protein
  • CAKB protein
  • CAKbeta protein
  • E430023O05Rik protein
  • FADK2 protein
  • FAK2 protein
  • PKB protein
  • PKB/Akt protein
  • PKBalpha protein
  • PTK protein
  • Pyk2 protein
  • Rac protein
  • Raftk protein

Protein level used designations for PTK2B

AKT1 kinase , PKB alpha , RAC protein kinase alpha RAC-PK alpha , RAC-PK-alpha , RAC-alpha serine/threonine-protein kinase , murine thymoma viral (v-akt) oncogene homolog 1 , protein kinase B alpha , thymoma viral proto-oncogene 1 , protein kinase B-alpha , proto-oncogene c-AKT , related to A and C kinases , CAK-beta , FADK 2 , PTK2B protein tyrosine kinase 2 beta , calcium-dependent tyrosine kinase , calcium-regulated non-receptor proline-rich tyrosine kinase , cell adhesion kinase beta , focal adhesion kinase 2 , proline-rich tyrosine kinase 2 , protein kinase B , protein-tyrosine kinase 2-beta , related adhesion focal tyrosine kinase , CADTK , CAK beta , PTK2 protein tyrosine kinase 2 beta , cellular adhesion kinase beta , protein tyrosine kinase 2 beta

GENE ID SPECIES
24185 Rattus norvegicus
11651 Mus musculus
2185 Homo sapiens
50646 Rattus norvegicus
19229 Mus musculus
486102 Canis lupus familiaris
541008 Bos taurus
421998 Gallus gallus
100157507 Sus scrofa
100342358 Oryctolagus cuniculus
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