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shelterin protein TIN2 (show TINF2 ELISA Kits) can protect chromosome ends as a TRF2 (show TERF2 ELISA Kits)-tethered TIN2 (show TINF2 ELISA Kits)/TPP1 (show TPP1 ELISA Kits)/POT1 (show POT1 ELISA Kits) complex that lacks a physical connection to TRF1 (show TERF1 ELISA Kits)
Mouse hematopoietic stem cells are acutely sensitive to inactivation of the shelterin gene Acd.
Tpp1 (show TPP1 ELISA Kits) is required for the protective function of Pot1 (show POT1 ELISA Kits) proteins.
Tumors from Acd(acd/acd) p53 (show TP53 ELISA Kits)(+/-) mice show a striking switch from the classic spectrum of p53 (show TP53 ELISA Kits)(-/-) mice toward carcinomas.
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends\; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity (By similarity). Plays a role in shelterin complex assembly. May play an essential role in organogenesis of the developing embryo.
adrenocortical dysplasia protein