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Gene expression analysis identified deregulation of histone H2A and H2B genes in all four cell lines ;histone pathways are associated with epirubicin resistance
kinetics of the accumulation of selected DNA repair-related proteins is protein specific at locally induced DNA lesions, and that the formation of gH2AX- and NBS1 (show NBN Proteins)-positive foci, but not 53BP1 (show TP53BP1 Proteins)-positive NBs (show NBN Proteins), is cell cycle dependent in HeLa cells
The interaction of MDC1 with RNF8 (show RNF8 Proteins), but not with ATM (show ATM Proteins) requires WRAP53beta, suggesting that WRAP53beta facilitates the former interaction without altering phosphorylation of MDC1 by ATM (show ATM Proteins).
the interaction of 53BP1 (show TP53BP1 Proteins) with gammaH2AX is required for sustaining the 53BP1 (show TP53BP1 Proteins)-dependent focal concentration of activated ATM (show ATM Proteins) that facilitates repair of DNA double-strand breaks in heterochromatin in G1.
X-rays induce prolonged and ATM (show ATM Proteins)-independent persistence of gammaH2AX foci in human gingival mesenchymal stem cells
Cell levels of gammaH2Ax define the G2 phase of the cell cycle.
The study shows higher expression of gamma-H2AX and 53BP1 (show TP53BP1 Proteins) foci in rectal cancer patients compared with healthy individuals. Yet the data in vitro were not predictive in regard to the radiotherapy outcome.
overexpression of TIPRL promotes phosphorylation of H2AX, and increases gamma-H2AX positive foci in response to DNA damage, whereas knockdown of TIPRL inhibits gamma-H2AX phosphorylation
For both, gamma-H2AX and 53BP1 (show TP53BP1 Proteins), the cellular focus number as well as the percentage of positive cells did not differ between patients with clinically isolated syndrome/early relapsing-remitting multiple sclerosis and healthy controls.
silencing or removing H2A.X induces mesenchymal-like characteristics including activation of EMT transcription factors, Slug and ZEB1, in HCT116 human colon cancer cells.
These data suggest a role for FoxO3a in the maintenance of genome integrity in response to DNA damage that is mediated by H2AX via yet unknown mechanisms.
link gamma-H2AX to transcription, assigning a new function for this DNA damage marker
DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.
Exposure to Cr(VI) induced villus blunting and crypt hyperplasia in the duodenum. gamma-H2AX immunostaining was elevated in villi, but not in the crypt compartment.
Data indicate that crypts exposed to 180 ppm hexavalent chromium Cr(VI) appeared healthy and exhibited no difference in gammaH2ax (gamma-H2AX) staining relative to those of control.
the gamma-H2AX biomarker showed higher sensitivity to measure dose-rate effects after low-dose LDR X rays compared to MNi formation.
H2A.X is specifically targeted to and negatively regulates extraembryonic lineage gene expression in embryonic stem cells (ESCs (show NR2E3 Proteins)) and prevents trophectoderm lineage differentiation.
Oxidative DNA damage in postnatal retina increases during development. It is low during the first postnatal week when PARP-1 (show PARP1 Proteins) activity is high but increases thereafter.
Our results highlight an important role for p-CDK2(39) in influencing silencing of the sex chromosomes during male meiosis by interacting with gamma-H2AX.
These findings suggest a dimerize-then-rearrange model for H2A-H2B dimers.
Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (show TRH Proteins)(16) by Chk1 (show CHEK1 Proteins).
H2Ax phosphorylated protein was detected in in parthenogenetically activated, in vitro fertilized and cloned bovine embryos.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.
, histone H2A.x
, histone 5 protein 2ax
, histone H2A type 1