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Browse our H2A Histone Family, Member X Proteins (H2AFX)

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H2A Histone Family, Member X Proteins (H2AFX)
On www.antibodies-online.com are 9 H2A Histone Family, Member X (H2AFX) Proteins from 5 different suppliers available. Additionally we are shipping H2A Histone Family, Member X Antibodies (335) and H2A Histone Family, Member X Kits (17) and many more products for this protein. A total of 374 H2A Histone Family, Member X products are currently listed.
Synonyms:
AW228881, gammaH2ax, h2a, h2a.x, h2a/x, h2afx, h2ax, Hist5-2ax, RGD1566119, zgc:56329
list all proteins Gene Name GeneID UniProt
H2AFX 3014 P16104
H2AFX 15270 P27661
Rat H2AFX H2AFX 500987  

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H2A Histone Family, Member X Proteins (H2AFX) by Origin

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More Proteins for H2A Histone Family, Member X Interaction Partners

Human H2A Histone Family, Member X (H2AFX) interaction partners

  1. we found that gamma-H2AX foci at chromosome boundaries after carbon-ion irradiation contain DNA double strand breaks undergoing DNA-end resection, which promotes repair utilizing microhomology mediated end-joining during translocation.

  2. this study demonstrates an early DDR (show DDR1 Proteins) defect of attenuated gammaH2AX signals in G0/G1 phase HGPS (show Zmpste24 Proteins) cells and provides a plausible connection between H3K9me3 loss and DDR (show DDR1 Proteins) deficiency.

  3. Data indicate an important role for histone H2A.X (H2AX) Tyr39 phosphorylation in gamma-H2A.X formation and cancer progression.

  4. we suggest that the XAB2 (show XAB2 Proteins) complex mediates DNA damage response events important for the end resection step of homologous recombination , and speculate that its adjacent-localization relative to double-strand break marked by gH2AX is important for this function

  5. the epithelial-mesenchymal transition-related transcription factor Twist1 (show TWIST1 Proteins) cooperates with Slug (show SNAI2 Proteins) to regulate EMT (show ITK Proteins) upon H2A.X Loss.

  6. Upon DNA damage, an increase in the levels of chromatin bound motor protein nuclear myosin 1 (NM1 (show MYO1C Proteins)) ensues, which appears to be functionally linked to Upsilon-H2AX signaling.

  7. TRAF6 (show TRAF6 Proteins) and H2AX overexpression and gammaH2AX-mediated HIF1alpha (show HIF1A Proteins) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (show HIF1A Proteins)-driven tumorigenesis, glycolysis and metastasis.

  8. gammaH2AX, claimed to be a marker of DNA double-strand breaks, was found in cell extracts of HeLa cells at elevated temperature vs. 37.0 degrees C, and these gammaH2AX signals were intensified in the presence of 3-aminobenzamide, a PARP inhibitor.

  9. Data provide evidence that the acetylation of H2AX at Lys5 (show AASDHPPT Proteins) by TIP60 (show KAT5 Proteins) is required for the (ADPribosyl) ation activity and the dynamic binding of PARP-1 (show PARP1 Proteins) to chromatin after the induction of DNA damage.

  10. data cannot finally exclude H2AX methylation of SUV39H2 (show SUV39H2 Proteins) in cells, additional experimental evidence is required to validate this claim.

Mouse (Murine) H2A Histone Family, Member X (H2AFX) interaction partners

  1. TRAF6 (show TRAF6 Proteins) and H2AX overexpression and gammaH2AX-mediated HIF1alpha (show HIF1A Proteins) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (show HIF1A Proteins)-driven tumorigenesis, glycolysis and metastasis.

  2. The findings highlight specific non-overlapping functions of PARP1 (show PARP1 Proteins) and PARP2 (show PARP2 Proteins) at H2AX-deficient chromatin during replicative phases of the cell cycle and uncover a unique requirement for PARP1 (show PARP1 Proteins) in nonhomologous end-joining-deficient cells.

  3. Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 (show RAD51 Proteins) and 53BP1 (show TP53BP1 Proteins) were recruited to these sites. H2AX was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX foci formation and DSB repair, whereas H2AX was barely stabilized in response to secondary DSBs, in which gammaH2AX foci were small and DSBs were not efficiently repaired

  4. this study shows that T cells and thyrocytes in a mouse model of thyrocyte hyperplasia has foci of phosphorylated histone protein H2A.X, indicative of cellular senescence

  5. The role of H2AX phosphorylation and H3K56 acetylation on normal stem cell response to radiation

  6. H2AX knockout mice showed cell-autonomous anaemia and erythroid dysplasia, mimicking dyserythropoiesis in MDS (show MECOM Proteins).

  7. These data suggest a role for FoxO3a in the maintenance of genome integrity in response to DNA damage that is mediated by H2AX via yet unknown mechanisms.

  8. overexpression of TIPRL promotes phosphorylation of H2AX, and increases gamma-H2AX positive foci in response to DNA damage, whereas knockdown of TIPRL inhibits gamma-H2AX phosphorylation

  9. link gamma-H2AX to transcription, assigning a new function for this DNA damage marker

  10. DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.

Xenopus laevis H2A Histone Family, Member X (H2AFX) interaction partners

  1. These findings suggest a dimerize-then-rearrange model for H2A-H2B dimers.

  2. Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (show TRH Proteins)(16) by Chk1 (show CHEK1 Proteins).

Cow (Bovine) H2A Histone Family, Member X (H2AFX) interaction partners

  1. H2Ax phosphorylated protein was detected in in parthenogenetically activated, in vitro fertilized and cloned bovine embryos.

H2A Histone Family, Member X (H2AFX) Protein Profile

Protein Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.

Alternative names and synonyms associated with H2A Histone Family, Member X (H2AFX)

  • H2A histone family, member X (H2AFX)
  • H2A histone family, member X (H2afx)
  • H2A histone family, member X (h2afx)
  • histone cluster 1, H2ah (HIST1H2AH)
  • histone cluster 2, H2ab (hist2h2ab)
  • histone H2A.x-like (LOC100522201)
  • histone H2A.x-like (LOC100720536)
  • AW228881 protein
  • gammaH2ax protein
  • h2a protein
  • h2a.x protein
  • h2a/x protein
  • h2afx protein
  • h2ax protein
  • Hist5-2ax protein
  • RGD1566119 protein
  • zgc:56329 protein

Protein level used designations for H2AFX

H2AX histone , histone H2A.x , H2a/x , histone 5 protein 2ax , H2A.X , histone H2A type 1

GENE ID SPECIES
3014 Homo sapiens
15270 Mus musculus
394048 Danio rerio
734746 Xenopus laevis
531733 Bos taurus
500987 Rattus norvegicus
418708 Gallus gallus
444528 Xenopus laevis
100522201 Sus scrofa
100720536 Cavia porcellus
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