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Browse our H2A Histone Family, Member X Proteins (H2AFX)

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H2A Histone Family, Member X Proteins (H2AFX)
On are 9 H2A Histone Family, Member X (H2AFX) Proteins from 5 different suppliers available. Additionally we are shipping H2A Histone Family, Member X Antibodies (346) and H2A Histone Family, Member X Kits (15) and many more products for this protein. A total of 383 H2A Histone Family, Member X products are currently listed.
AW228881, gammaH2ax, h2a, h2a.x, h2a/x, h2afx, h2ax, Hist5-2ax, RGD1566119, zgc:56329
list all proteins Gene Name GeneID UniProt
H2AFX 3014 P16104
H2AFX 15270 P27661
Rat H2AFX H2AFX 500987  

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H2A Histone Family, Member X Proteins (H2AFX) by Origin

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Human H2A Histone Family, Member X (H2AFX) interaction partners

  1. data cannot finally exclude H2AX methylation of SUV39H2 (show SUV39H2 Proteins) in cells, additional experimental evidence is required to validate this claim.

  2. This review outlines the role of gamma-H2AX in cell cycle, and its formation as a result of DNA damage. We investigate the role of gamma-H2AX formation in several cancer types and its correlation with other prognostic factors, and we try to find out whether it fulfills the requirements for its establishment as a classical cancer prognostic factor

  3. dyserythropoiesis was increased in MDS patients with the deletion of chromosome 11q23, where H2AX is located. (show PAFAH1B1 Proteins) Although loss of H2AX did not affect the early stage of terminal erythropoiesis, enucleation was decreased.

  4. the formation of 53BP1 (show TP53BP1 Proteins), gammaH2AX foci and their co-localization induced by gamma-rays (2, 5, 10, 50, 200 cGy) in human lymphocytes, was analyzed.

  5. 5-Hydroxymethylcytosine (5hmC) accumulates at DNA damage foci and colocalizes with major DNA damage response proteins 53BP1 (show TP53BP1 Proteins) and gH2AX, revealing 5hmC as an epigenetic marker of DNA damage.

  6. Anacardic acid sensitizes prostate cancer cells to radiation therapy by repressing H2AX expression.

  7. Results reveal a pathway controlled by ATM, SIRT6, and SNF2H to block HUWE1, which stabilizes H2AX and induces its incorporation into chromatin only when cells are damaged.

  8. Gene expression analysis identified deregulation of histone H2A and H2B genes in all four cell lines ;histone pathways are associated with epirubicin resistance

  9. kinetics of the accumulation of selected DNA repair-related proteins is protein specific at locally induced DNA lesions, and that the formation of gH2AX- and NBS1 (show NBN Proteins)-positive foci, but not 53BP1 (show TP53BP1 Proteins)-positive NBs (show NBN Proteins), is cell cycle dependent in HeLa cells

  10. The interaction of MDC1 with RNF8 (show RNF8 Proteins), but not with ATM (show ATM Proteins) requires WRAP53beta, suggesting that WRAP53beta facilitates the former interaction without altering phosphorylation of MDC1 by ATM (show ATM Proteins).

Mouse (Murine) H2A Histone Family, Member X (H2AFX) interaction partners

  1. Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 (show RAD51 Proteins) and 53BP1 (show TP53BP1 Proteins) were recruited to these sites. H2AX was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX foci formation and DSB repair, whereas H2AX was barely stabilized in response to secondary DSBs, in which gammaH2AX foci were small and DSBs were not efficiently repaired

  2. this study shows that T cells and thyrocytes in a mouse model of thyrocyte hyperplasia has foci of phosphorylated histone protein H2A.X, indicative of cellular senescence

  3. The role of H2AX phosphorylation and H3K56 acetylation on normal stem cell response to radiation

  4. H2AX knockout mice showed cell-autonomous anaemia and erythroid dysplasia, mimicking dyserythropoiesis in MDS (show MECOM Proteins).

  5. These data suggest a role for FoxO3a in the maintenance of genome integrity in response to DNA damage that is mediated by H2AX via yet unknown mechanisms.

  6. overexpression of TIPRL promotes phosphorylation of H2AX, and increases gamma-H2AX positive foci in response to DNA damage, whereas knockdown of TIPRL inhibits gamma-H2AX phosphorylation

  7. link gamma-H2AX to transcription, assigning a new function for this DNA damage marker

  8. DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.

  9. Exposure to Cr(VI) induced villus blunting and crypt hyperplasia in the duodenum. gamma-H2AX immunostaining was elevated in villi, but not in the crypt compartment.

  10. Data indicate that crypts exposed to 180 ppm hexavalent chromium Cr(VI) appeared healthy and exhibited no difference in gammaH2ax (gamma-H2AX) staining relative to those of control.

Xenopus laevis H2A Histone Family, Member X (H2AFX) interaction partners

  1. These findings suggest a dimerize-then-rearrange model for H2A-H2B dimers.

  2. Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (show TRH Proteins)(16) by Chk1 (show CHEK1 Proteins).

Cow (Bovine) H2A Histone Family, Member X (H2AFX) interaction partners

  1. H2Ax phosphorylated protein was detected in in parthenogenetically activated, in vitro fertilized and cloned bovine embryos.

H2A Histone Family, Member X (H2AFX) Protein Profile

Protein Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.

Alternative names and synonyms associated with H2A Histone Family, Member X (H2AFX)

  • H2A histone family, member X (H2AFX)
  • H2A histone family, member X (H2afx)
  • H2A histone family, member X (h2afx)
  • histone cluster 1, H2ah (HIST1H2AH)
  • histone cluster 2, H2ab (hist2h2ab)
  • histone H2A.x-like (LOC100522201)
  • histone H2A.x-like (LOC100720536)
  • AW228881 protein
  • gammaH2ax protein
  • h2a protein
  • h2a.x protein
  • h2a/x protein
  • h2afx protein
  • h2ax protein
  • Hist5-2ax protein
  • RGD1566119 protein
  • zgc:56329 protein

Protein level used designations for H2AFX

H2AX histone , histone H2A.x , H2a/x , histone 5 protein 2ax , H2A.X , histone H2A type 1

3014 Homo sapiens
15270 Mus musculus
394048 Danio rerio
734746 Xenopus laevis
531733 Bos taurus
500987 Rattus norvegicus
418708 Gallus gallus
444528 Xenopus laevis
100522201 Sus scrofa
100720536 Cavia porcellus
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