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RFC1 plays critical roles in abscisic acid-mediated homologous recombination in Arabidopsis.
That RFC1 is found in divergent eukaryotes suggests a previously unrecognized and highly conserved role for DNA synthesis in discriminating between recombination pathways.
results suggest that RFC1 helps mediate genomic stability and transcriptional gene silencing in Arabidopsis thaliana
Dada (show ADA Proteins) suggest that AtRFC1 plays an important role in embryo development in Arabidopsis thaliana.
The mRNAs encoding Folr2 and the intestinal folate transporter Slc46a1 were not detected in 2-cel embryos and blastocysts.
Interleukin-6 (show IL6 Proteins) regulated the efficacy of methotrexate by decreasing the expression of SLC19A1 (show SLC19A1 Proteins).
First evidence of RFC (show SLC19A1 Proteins) expression in rapidly dividing cells of developing neural tube, craniofacial region, limb buds and heart duggests that these regions may be particularly susceptible to folate deficiency.
Inactivation of RFC1 impacts the expression of several ligands and interacting proteins in the cubilin (show CUBN Proteins)-amnionless (show AMN Proteins)-megalin (show LRP2 Proteins) complex that are involved in the maternal-fetal transport of folate and other nutrients.
Intestinal folate uptake process undergoes differentiation-dependent regulation and that this regulation is mediated via changes in the level of expression of both the RFC (show SLC19A1 Proteins) and PCFT (show SLC46A1 Proteins).
Human CTF18-RFC clamp-loader complexed with non-synthesising POLE efficiently loads the PCNA sliding clamp.
this meta-analysis shows that RFC1 gene polymorphism is associated with responsiveness to methotrexate therapy, but may not be associated with methotrexate toxicity in rheumatoid arthritis patients
RFC-1 80G > A gene polymorphism is not associated with methotrexate treatment response in South Indian Tamils with rheumatoid arthritis
The MTHFR (show MTHFR Proteins) 677CC and GGH (show GGH Proteins) 401TT and CT genotypes were associated with a reduction in the number of MTX (show MTX1 Proteins)-related adverse events
We conclude that bearing allele G of rs1051266 polymorphism in RFC1 may contribute to increased efficacy of MTX (show MTX1 Proteins) treatment and may contribute to improved outcome in osteosarcoma patients
We found that the compound mutation genotypes MTHFD (show MTHFD1 Proteins)-G1958A, MTR (show MTR Proteins)-A2756G, and RFC1-G80A increased the risk of preterm birth (OR = 2.88, 95%CI = 1.08-7.72, P = 0.028).
3 biallelic polymorphic variants (rs1051266, rs4818789 and rs3788205) were selected. Results provided support suggesting role of RFC1 in NSCL (show NHLH1 Proteins)/P etiology, reinforcing idea genetic predisposition to NSCL (show NHLH1 Proteins)/P varies in different ethnic groups.
this is the first study to simultaneously evaluate both DNA methylation (show HELLS Proteins) and protein expression of all three folate transporter genes, FOLR1 (show FOLR1 Proteins), PCFT (show SLC46A1 Proteins), and RFC1, in colorectal cancer.
The frequency of RFC-1 rs1051266 (G80A) was 58.4% and 57.1% in children with nephroblastoma and neuroblastoma (show ARHGEF16 Proteins), respectively. Mother and child G80A genotypes play a role in the risk of neuroblastoma (show ARHGEF16 Proteins) and nephroblastoma.
RFC depletion had a negative impact on LANA's ability to replicate and maintain viral DNA in cells containing artificial KSHV episomes or in infected cells, leading to loss of virus.
This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
A1 140 kDa subunit
, ISRE-binding protein
, RF-C 140 kDa subunit
, activator 1 140 kDa subunit
, activator 1 large subunit
, activator 1 subunit 1
, differentiation-specific element-binding protein
, replication factor C 1
, replication factor C 140 kDa subunit
, replication factor C large subunit
, replication factor C subunit 1
, replication factor C, 140 kDa
, DNA-binding protein PO-GA
, MHC binding factor, beta
, replication factor C1
, folate transporter 1
, intestinal folate carrier 1
, intestinal folate carrier protein
, reduced folate carrier 1
, solute carrier family 19 (sodium/hydrogen exchanger), member 1
, solute carrier family 19 member 1
, methotrexate carrier 1
, methotrexate carrier 2
, methotrexate carrier 5
, methotrexate carrier 6
, solute carrier family 19, member 1