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Upregulation by BCR/ABL (show ABL1 Proteins) requires activation of STAT5 (show STAT5A Proteins) and plays a key role in the BCR/ABL (show ABL1 Proteins)-mediated cell protection from apoptosis.
evidence is presented for a novel interaction between RFC40 and the RIalpha (show PRKAR1A Proteins) subunit of PKA; findings indicate that modulation in the formation of the RFC40-RIa complex is associated with decreased cell survival
The cAMP functions as an upstream modulator that regulates the expression and nuclear translocation of RFC40 protein.
RPA (show RPA1 Proteins) plays a regulatory role in DNA damage responses via repression of RFC2 ubiquitylation in human cells.
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described.
replication factor C (activator 1) 2, 40kDa
, replication factor C subunit 2-like
, activator 1 subunit C2
, replication factor C subunit 2
, A1 40 kDa subunit
, RF-C 40 kDa subunit
, activator 1 40 kDa subunit
, activator 1 subunit 2
, replication factor C 40 kDa subunit
, replication factor C, 40 kDa
, replication factor C/activator 1 subunit