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trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase
The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.
methylation status of the genes of telomerase reverse transcriptase (tert) and telomerase RNA (terc) was determined in brain tissues; study found that, regardless of the age of fish, the regulatory region of the tert gene was completely methylated, whereas the coding region remained unmethylated
Telomerase-deficient zebrafish show p53 (show TP53 Proteins)-dependent premature aging and reduced lifespan in the first generation.
These results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis.
Telomerase regulatory subunit Est3 in Candida species physically interacts with the TEN domain of TERT and telomeric DNA
Tert was cloned from testis. It is expresed in embryo and adult, mostly in gonad and brain. 2 splice variants and an antisense transcript were identified.
The Japanese medaka is a new vertebrate model for studying tert biology.
ANG 1 (show ANGPT1 Proteins)-7 exerts vasoprotection in the human microvasculature via modulation of telomerase activity.
Results found an association between rs2736100 (in TERT) and levels of methylation at cg23827991 (localized in the same gene, 3.3 kbp (show KIAA1279 Proteins) downstream of the risk variant) in glioma, which was validated in the TCGA glioblastoma dataset.
This study showed that rs2735940 hTERT CX-TT donor-recipient genotype pair was associated with almost five times higher odds (OR=4.82; 95% CI: 1.32-18; p=0.016) of delayed graft function (DGF), and that rs2735940 hTERT, rs2630578 BICD1 (show BICD1 Proteins), and rs7235755 chromosome 18 polymorphisms combined pairs were not associated with acute rejection (AR).
our data suggest that hTERTR-FAM96A (show FAM96A Proteins) may serve as an efficient anti-tumor agent for the treatment of hepatocellular carcinoma.
TERT has a role in neointima formation through epigenetic regulation of proliferative E2F1 (show E2F1 Proteins) target gene expression in smooth muscle cells.
TERT promoter mutations are present in a subset of mostly intracranial conventional ependymomas in adults.
TGF-beta (show TGFB1 Proteins) receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.(
This study presents the structure of the human TERT thumb (hThumb) domain determined by the method of single-wavelength anomalous diffraction to 2.31 A resolution. The study used direct telomerase activity and nucleic acid binding assays to explain how naturally occurring mutations within this portion of telomerase contribute to human disease.
hTERT facilitates tumor angiogenesis by up-regulating VEGF (show VEGFA Proteins) expression through direct interactions with the VEGF (show VEGFA Proteins) gene and the Sp1 transcription factor (show SP1 Proteins).
Structural Mechanism Underpinning Cross-reactivity of a CD8 (show CD8A Proteins)+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.(
these findings support a model in which gain of TERT function modulates mTORC1 activity and induces autophagy.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (show MYC Proteins), Cyc (show CYCS Proteins)-D1 and TERT, respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment
Results suggest that in mature Purkinje neurons, TERT is present both in the nucleus and in mitochondria, where it may participate in adaptive responses of the neurons to excitotoxic and radiation stress
Wnt10a (show WNT10A Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT.
This study reports the characterisation of two novel mouse TERT splice variants, Ins (show INS Proteins)-i1[1-102] (Insi1 for short) and Del-e12 (show ELSPBP1 Proteins)[1-40] (Dele12 for short) that have not been previously described. Insi1 represents an in-frame insertion of nucleotides 1-102 from intron 1, encoding a 34 amino acid insertion at amino acid 73.
TERT may promote gastric cancer metastasis through the TERT-miR (show MLXIP Proteins)-29a-ITGB1 (show ITGB1 Proteins) regulatory pathway.
TERT switches macrophages towards M1 phenotype by regulating NF-kappaB (show NFKB1 Proteins) signaling, but has limited effect on M2 macrophages polarization in vitro.
miR (show MLXIP Proteins)-195 overexpressed in old mesenchymal stem cells (OMSCs) induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase (Tert), and abrogation of miR (show MLXIP Proteins)-195 can reverse stem cell aging.
findings identified a key role for TERT in fibroblast proliferation and survival essential for pulmonary fibrosis
Telomere shortening is more rapid in fas (show FASN Proteins) tert double mutants than in fas1 (show FAS Proteins), fas2 or tert single mutant plants.
Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
study reports the physical interaction of an Arabidopsis POT1 (show POT1 Proteins) protein, POT1A (show POT1 Proteins) (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant
AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 (show DKC1 Proteins) associates with active telomerase RNP (show RNPC3 Proteins) particles in an RNA-dependent manner.
Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified\; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Telomerase Reverse Transcriptase family member (trt-1)
, telomerase reverse transcriptase
, hypothetical protein
, Telomerase catalytic subunit
, telomerase catalytic subunit
, telomerase-associated protein 2
, telomerase reverse transcriptase beta