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Browse our TERT Proteins (TERT)

Full name:
Telomerase Reverse Transcriptase Proteins (TERT)
On are 13 Telomerase Reverse Transcriptase (TERT) Proteins from 5 different suppliers available. Additionally we are shipping TERT Antibodies (246) and TERT Kits (68) and many more products for this protein. A total of 343 TERT products are currently listed.
ATTERT, chTERT, CMM9, DKCA2, DKCB4, EST2, F5E19.190, F5E19_190, hEST2, hTRT, PFBMFT1, TCS1, telomerase reverse transcriptase, tert, TP2, TR, TRT
list all proteins Gene Name GeneID UniProt
TERT 7015 O14746
TERT 21752 O70372
TERT 301965 Q673L6

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TERT Proteins (TERT) by Origin

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More Proteins for TERT Interaction Partners

Caenorhabditis elegans (C. elegans) Telomerase Reverse Transcriptase (TERT) interaction partners

  1. trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase

Zebrafish Telomerase Reverse Transcriptase (TERT) interaction partners

  1. The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.

  2. methylation status of the genes of telomerase reverse transcriptase (tert) and telomerase RNA (terc) was determined in brain tissues; study found that, regardless of the age of fish, the regulatory region of the tert gene was completely methylated, whereas the coding region remained unmethylated

  3. Telomerase-deficient zebrafish show p53 (show TP53 Proteins)-dependent premature aging and reduced lifespan in the first generation.

  4. These results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis.

Candida albicans Telomerase Reverse Transcriptase (TERT) interaction partners

  1. Telomerase regulatory subunit Est3 in Candida species physically interacts with the TEN domain of TERT and telomeric DNA

Medaka Telomerase Reverse Transcriptase (TERT) interaction partners

  1. Tert was cloned from testis. It is expresed in embryo and adult, mostly in gonad and brain. 2 splice variants and an antisense transcript were identified.

  2. The Japanese medaka is a new vertebrate model for studying tert biology.

Human Telomerase Reverse Transcriptase (TERT) interaction partners

  1. The current study provided the characteristics of genetic aberrations in NAFLD-HCC and suggested that TERT promoter mutations and chromosome 8p loss mainly contribute to NAFLD-related liver carcinogenesis

  2. A splicing variant in TERT, rs10069690, showed a statistically significant interaction with ET use for risk of serous ovarian cancer (pint = 0.013).

  3. TERT promoter mutations are not associated with pituitary adenomas.

  4. The TERT promoter mutations (C228T and C250T) are the most common genetic alterations in urothelial carcinoma and are not associated with tumor locations, grade, or invasiveness.

  5. A significantly negative correlation between PTEN and hTERT gene expression indicates that hTERT activation and upregulation may be conferred by the loss of PTEN gene expression in hepatocellular carcinoma (HCC (show FAM126A Proteins)).

  6. Several papers converge to suggest that DNA methylation (show HELLS Proteins), histone modification, and small non-coding RNAs are the widely appreciated epigenetic changes towards hTERT modulation. In this review, we summarize the contribution of epigenetic factors in the telomerase activation and discuss potential avenues to achieve therapeutic intervention in carcinoma.

  7. Sarcomatoid carcinoma of the upper urinary tract is an aggressive tumor and the presence of TERT mutation may portend poor prognosis.

  8. The results of current study indicated that G allele of the rs2736100 and A allele of the rs2736098 of TERT were associated with increased Non-Small Cell Lung Cancers Risk.

  9. ndoG digests long non-coding RNA and produces 47-mer (show MERTK Proteins) RNA oligonucleotide complementary to hTERT pre-mRNA exon 8 and intron 8 junction place. Interaction of 47-mer (show MERTK Proteins) RNA oligonucleotide and hTERT pre-mRNA causes alternative splicing.

  10. Overexpression of EndoG (show ENDOG Proteins) in CD4 (show CD4 Proteins)+ T cells downregulated the expression of the active full-length hTERT variant and upregulated the inactive alternatively spliced variant.

Mouse (Murine) Telomerase Reverse Transcriptase (TERT) interaction partners

  1. Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (show MYC Proteins), Cyc (show CYCS Proteins)-D1 and TERT, respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment

  2. Results suggest that in mature Purkinje neurons, TERT is present both in the nucleus and in mitochondria, where it may participate in adaptive responses of the neurons to excitotoxic and radiation stress

  3. Wnt10a (show WNT10A Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT.

  4. This study reports the characterisation of two novel mouse TERT splice variants, Ins (show INS Proteins)-i1[1-102] (Insi1 for short) and Del-e12 (show ELSPBP1 Proteins)[1-40] (Dele12 for short) that have not been previously described. Insi1 represents an in-frame insertion of nucleotides 1-102 from intron 1, encoding a 34 amino acid insertion at amino acid 73.

  5. TERT may promote gastric cancer metastasis through the TERT-miR (show MLXIP Proteins)-29a-ITGB1 (show ITGB1 Proteins) regulatory pathway.

  6. TERT switches macrophages towards M1 phenotype by regulating NF-kappaB (show NFKB1 Proteins) signaling, but has limited effect on M2 macrophages polarization in vitro.

  7. miR (show MLXIP Proteins)-195 overexpressed in old mesenchymal stem cells (OMSCs) induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase (Tert), and abrogation of miR (show MLXIP Proteins)-195 can reverse stem cell aging.

  8. findings identified a key role for TERT in fibroblast proliferation and survival essential for pulmonary fibrosis

  9. miR (show MLXIP Proteins)-512-5p suppresses tumor growth by targeting TERT in telomerase positive head and neck squamous cell carcinoma in vitro and in vivo.

  10. data suggest that S1P (show S1PR1 Proteins) binding to hTERT allosterically mimicks phosphorylation, promoting telomerase stability and hence telomere maintenance, cell proliferation, and tumor growth.

Cow (Bovine) Telomerase Reverse Transcriptase (TERT) interaction partners

Arabidopsis thaliana Telomerase Reverse Transcriptase (TERT) interaction partners

  1. Telomere shortening is more rapid in fas (show FASN Proteins) tert double mutants than in fas1 (show FAS Proteins), fas2 or tert single mutant plants.

  2. Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.

  3. study reports the physical interaction of an Arabidopsis POT1 (show POT1 Proteins) protein, POT1A (show POT1 Proteins) (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant

  4. AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 (show DKC1 Proteins) associates with active telomerase RNP (show RNPC3 Proteins) particles in an RNA-dependent manner.

  5. Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.

TERT Protein Profile

Protein Summary

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified\; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

Alternative names and synonyms associated with TERT

  • Telomerase Reverse Transcriptase (trt-1)
  • telomerase reverse transcriptase (Tert)
  • telomerase reverse transcriptase (tert)
  • telomerase reverse transcriptase (TRT1)
  • telomerase reverse transcriptase (CMU_003490)
  • telomerase reverse transcriptase (VDBG_04487)
  • Telomerase catalytic subunit (GL50803_16225)
  • telomerase reverse transcriptase (TERT)
  • ATTERT protein
  • chTERT protein
  • CMM9 protein
  • DKCA2 protein
  • DKCB4 protein
  • EST2 protein
  • F5E19.190 protein
  • F5E19_190 protein
  • hEST2 protein
  • hTRT protein
  • PFBMFT1 protein
  • TCS1 protein
  • telomerase reverse transcriptase protein
  • tert protein
  • TP2 protein
  • TR protein
  • TRT protein

Protein level used designations for TERT

Telomerase Reverse Transcriptase family member (trt-1) , telomerase reverse transcriptase , hypothetical protein , Telomerase catalytic subunit , telomerase catalytic subunit , telomerase-associated protein 2 , telomerase reverse transcriptase beta

172688 Caenorhabditis elegans
658162 Tribolium castaneum
796551 Danio rerio
3640729 Candida albicans SC5314
3640809 Candida albicans SC5314
6997965 Cryptosporidium muris RN66
9530095 Verticillium alfalfae VaMs.102
100049443 Oryzias latipes
5702495 Giardia lamblia ATCC 50803
7015 Homo sapiens
21752 Mus musculus
301965 Rattus norvegicus
518884 Bos taurus
403412 Canis lupus familiaris
492280 Sus scrofa
420972 Gallus gallus
100732437 Cavia porcellus
831548 Arabidopsis thaliana
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