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trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase
The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.
methylation status of the genes of telomerase reverse transcriptase (tert) and telomerase RNA (terc) was determined in brain tissues; study found that, regardless of the age of fish, the regulatory region of the tert gene was completely methylated, whereas the coding region remained unmethylated
Telomerase-deficient zebrafish show p53 (show TP53 Proteins)-dependent premature aging and reduced lifespan in the first generation.
These results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis.
Telomerase regulatory subunit Est3 in Candida species physically interacts with the TEN domain of TERT and telomeric DNA
Tert was cloned from testis. It is expresed in embryo and adult, mostly in gonad and brain. 2 splice variants and an antisense transcript were identified.
The Japanese medaka is a new vertebrate model for studying tert biology.
The results showed that a repressor complex composed of NFX1 (show NFX1 Proteins)-91, mSin3A and histone deacetylase 1 (show HDAC1 Proteins) was involved in the PKC-delta (show PKCd Proteins)-induced repression of the hTERT promoter, which resulted in the repression of hTERT transcription.
Results indicate a noncanonical function for telomerase catalytic subunit (hTERT) in promoting tumorigenesis.
Gene alterations in TERT promoter, TP53 (show TP53 Proteins), CTNNB1 (show CTNNB1 Proteins), and hepatitis B virus integration were closely associated with hepatocellular carcinoma development, and mutations in TERT promoter are related to poor prognosis
A high percentage of glioma cell lines, as well as two meningioma cell lines, harbors TERT mutations.
Tert knockdown disrupts telomere homeostasis and could inhibit growth of fibroblasts in scar tissues.
A significant TERT hypermethylation in breast cancer cells was observed in four CpG islands as a sum, in comparison to methylation of the normal breast tissue.
Differences in patterns of methylation of the hTERT core promoter [region 1 (nt -208 to -1) and region 2 (nt +1 to +104) relative to first ATG] are related to the HPV species present.
Oncogenic TERT promoter mutations are present in a fraction of ALMs. No relevant associations were found between TERT mutation status and clinical/molecular features nor survival.
TERT promoter mutations and long telomere length is associated with radiotherapy resistance in gliomas.
Studies showed that TERT mutations occur early during cellular transformation, and activate the TERT promoter by recruiting transcription factors that do not normally regulate TERT gene expression. [review]
This study reports the characterisation of two novel mouse TERT splice variants, Ins (show INS Proteins)-i1[1-102] (Insi1 for short) and Del-e12 (show ELSPBP1 Proteins)[1-40] (Dele12 for short) that have not been previously described. Insi1 represents an in-frame insertion of nucleotides 1-102 from intron 1, encoding a 34 amino acid insertion at amino acid 73.
TERT may promote gastric cancer metastasis through the TERT-miR (show MLXIP Proteins)-29a-ITGB1 (show ITGB1 Proteins) regulatory pathway.
TERT switches macrophages towards M1 phenotype by regulating NF-kappaB (show NFKB1 Proteins) signaling, but has limited effect on M2 macrophages polarization in vitro.
miR (show MLXIP Proteins)-195 overexpressed in old mesenchymal stem cells (OMSCs) induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase (Tert), and abrogation of miR (show MLXIP Proteins)-195 can reverse stem cell aging.
findings identified a key role for TERT in fibroblast proliferation and survival essential for pulmonary fibrosis
miR (show MLXIP Proteins)-512-5p suppresses tumor growth by targeting TERT in telomerase positive head and neck squamous cell carcinoma in vitro and in vivo.
data suggest that S1P (show S1PR1 Proteins) binding to hTERT allosterically mimicks phosphorylation, promoting telomerase stability and hence telomere maintenance, cell proliferation, and tumor growth.
Telomerase may direct Pol I transcription in oncogenic and regenerative hyperproliferation.
Tert expression confers cardioprotection in the adult mouse heart after acute myocardial infarction.
TERT is a regulator of MYC (show MYC Proteins) stability in cancer. Reactivation of TERT, a direct transcriptional MYC (show MYC Proteins) target in tumors, provides a feed-forward mechanism to potentiate MYC (show MYC Proteins)-dependent oncogenesis.
Telomere shortening is more rapid in fas (show FASN Proteins) tert double mutants than in fas1 (show FAS Proteins), fas2 or tert single mutant plants.
Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
study reports the physical interaction of an Arabidopsis POT1 (show POT1 Proteins) protein, POT1A (show POT1 Proteins) (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant
AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 (show DKC1 Proteins) associates with active telomerase RNP (show RNPC3 Proteins) particles in an RNA-dependent manner.
Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified\; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Telomerase Reverse Transcriptase family member (trt-1)
, telomerase reverse transcriptase
, hypothetical protein
, Telomerase catalytic subunit
, telomerase catalytic subunit
, telomerase-associated protein 2
, telomerase reverse transcriptase beta