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Study investigated the anatomical specificity of TERT promoter mutations in 203 patients with primary glioblastomas. Brain regions associated with TERT promoter mutation status were identified by voxel-based statistical analysis analysis, demonstrating the anatomic specificity of TERT promoter mutation status.
We conclude that, in a routine diagnostic setting, TERT promoter mutations define a relatively homogeneous core group among IDH-wildtype diffuse gliomas that includes the majority of primary glioblastomas as well as their putative precursor lesions
research seems to provide strong evidence for an association between CLPTM1L rs402710C/T and TERT rs2736100A/C SNPs and the risk of OSSC, and suggests that higher tumor RTL values and positive hTERT expression may be applicable as early prognostic markers
Study demonstrated that local recurrent gastric cancer patients showed higher c-Myc (show MYC Proteins) and hTERT expression at the protein and mRNA levels, and that acidified bile acids enhance tumor progression and telomerase activity in gastric cancer via Myc (show MYC Proteins) activity.
FKBP51 (show FKBP4 Proteins) is primarily localized in mitochondria and hTERT is totally nuclear, upon the onset of oxidative stress, FKBP51 (show FKBP4 Proteins) (but not FKBP52 (show FKBP4 Proteins)) becomes mostly nuclear colocalizing with hTERT, and longer exposure times to peroxide favors hTERT export to mitochondria.
In adrenocortical carcinomas, the loss of N-cadherin (show CDH2 Proteins) is a frequent phenomenon while the existence of TERT promoter mutations is not, and nuclear telomerase expression is present in only a minority of cases.
CRISPR-mediated reversal of mutant TERT promoters, or deletion of its long-range interacting chromatin, abrogates GABPA (show GABPA Proteins) binding and long-range interactions, leading to depletion of active histone marks, loss of POL2 recruitment, and suppression of TERT transcription
Polymorphisms in the promoter region of TERT gene is associated with postoperative recurrence in thyroid carcinoma.
The significantly higher mitochondrial localization of TERT in tumors is consistent with its shuttling from the nucleus upon exposure to high OS.
Nrf2 (show GABPA Proteins)-driven TERT regulates pentose phosphate pathway in glioblastoma.
The results establish that null mutation in trt-1 improves survival and attenuates damage to the DAergic system.
trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase
The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.
methylation status of the genes of telomerase reverse transcriptase (tert) and telomerase RNA (terc) was determined in brain tissues; study found that, regardless of the age of fish, the regulatory region of the tert gene was completely methylated, whereas the coding region remained unmethylated
Telomerase-deficient zebrafish show p53 (show TP53 Proteins)-dependent premature aging and reduced lifespan in the first generation.
These results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis.
Telomere shortening is more rapid in fas (show FASN Proteins) tert double mutants than in fas1 (show FAS Proteins), fas2 or tert single mutant plants.
Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
study reports the physical interaction of an Arabidopsis POT1 (show POT1 Proteins) protein, POT1A (show POT1 Proteins) (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant
AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 (show DKC1 Proteins) associates with active telomerase RNP (show RNPC3 Proteins) particles in an RNA-dependent manner.
Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.
Tert was cloned from testis. It is expresed in embryo and adult, mostly in gonad and brain. 2 splice variants and an antisense transcript were identified.
The Japanese medaka is a new vertebrate model for studying tert biology.
Reactivation of Tert in the hippocampus was sufficient to normalize the depressive but not the aggressive behaviors of Tert(-/-) mice. Conversely, re-expression of Tert in the medial prefrontal cortex (mPFC) reversed the aggressive but not the depressive behavior of Tert(-/-) mice.
Nrf2 (show NFE2L2 Proteins)-driven TERT regulates pentose phosphate pathway in glioblastoma.
TERT has a role in neointima formation through epigenetic regulation of proliferative E2F1 (show E2F1 Proteins) target gene expression in smooth muscle cells.
these findings support a model in which gain of TERT function modulates mTORC1 activity and induces autophagy.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (show MYC Proteins), Cyc (show CYCS Proteins)-D1 and TERT, respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment
Results suggest that in mature Purkinje neurons, TERT is present both in the nucleus and in mitochondria, where it may participate in adaptive responses of the neurons to excitotoxic and radiation stress
Wnt10a (show WNT10A Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT.
This study reports the characterisation of two novel mouse TERT splice variants, Ins (show INS Proteins)-i1[1-102] (Insi1 for short) and Del-e12 (show ELSPBP1 Proteins)[1-40] (Dele12 for short) that have not been previously described. Insi1 represents an in-frame insertion of nucleotides 1-102 from intron 1, encoding a 34 amino acid insertion at amino acid 73.
TERT may promote gastric cancer metastasis through the TERT-miR (show MLXIP Proteins)-29a-ITGB1 (show ITGB1 Proteins) regulatory pathway.
TERT switches macrophages towards M1 phenotype by regulating NF-kappaB (show NFKB1 Proteins) signaling, but has limited effect on M2 macrophages polarization in vitro.
TERT serves an essential role in formation of the anterior-posterior axis in Xenopus laevis embryos; role for telomerase as a transcriptional modulator of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling pathway
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified\; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
telomerase catalytic subunit
, telomerase-associated protein 2
, Telomerase Reverse Transcriptase family member (trt-1)
, telomerase reverse transcriptase
, hypothetical protein
, telomerase reverse transcriptase beta
, Telomerase catalytic subunit