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trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase
The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.
methylation status of the genes of telomerase reverse transcriptase (tert) and telomerase RNA (terc) was determined in brain tissues; study found that, regardless of the age of fish, the regulatory region of the tert gene was completely methylated, whereas the coding region remained unmethylated
Telomerase-deficient zebrafish show p53 (show TP53 Proteins)-dependent premature aging and reduced lifespan in the first generation.
These results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis.
Telomerase regulatory subunit Est3 in Candida species physically interacts with the TEN domain of TERT and telomeric DNA
Tert was cloned from testis. It is expresed in embryo and adult, mostly in gonad and brain. 2 splice variants and an antisense transcript were identified.
The Japanese medaka is a new vertebrate model for studying tert biology.
This meta-analysis suggested that TERT rs2736109, rs2853669, rs2736098, and rs10069690 polymorphisms were associated with increased risk of developing breast cancer.
TERT mutation was found in 7 of 12 cases using paraffin-embedded neoplastic tissue
Our findings indicated that hTERT promoter-driven expression of the NIS gene in HeLa cells led to 188Re uptake and therapeutic effects. Thus, NIS-based gene therapy and imaging using the hTERT promoter and 188Re may be possible.
These data demonstrated that TERT promoter mutation is a frequent event in hepatocellular carcinoma; however, telomere length, but not the presence of a TERT promoter mutation, might have potential value as a prognostic indicator of hepatocellular carcinoma
The coexistence of BRAF (show BRAF Proteins) or RAS mutations enhanced the prognostic effects of telomerase reverse transcriptase (TERT) promoter mutations. Furthermore, TERT promoter mutations strengthened the predictions of mortality and recurrence by the ATA and TNM (show ODZ1 Proteins) staging systems, particularly for high-risk patients with differentiated thyroid cancer.
TERT promoter mutations do not seem to play a major role in the pathogenesis of pediatric papillary thyroid carcinomas
TERT promoter mutations, commonly found in conventional UC, to be frequently present in clinically aggressive micropapillary carcinoma
The analysis of the rs2853669 showed that variant C was present in 22.8 % of the cases. In conclusion, we showed for the first time that TERT promoter mutations occur in a small subset (~3 %) of testicular germ cell tumors
Wnt10a (show WNT10A Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT.
TERT promoter mutations showed a lower prevalence in our series and appeared to be associated with aggressive behavior
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (show MYC Proteins), Cyc (show CYCS Proteins)-D1 and TERT, respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment
Results suggest that in mature Purkinje neurons, TERT is present both in the nucleus and in mitochondria, where it may participate in adaptive responses of the neurons to excitotoxic and radiation stress
This study reports the characterisation of two novel mouse TERT splice variants, Ins (show INS Proteins)-i1[1-102] (Insi1 for short) and Del-e12 (show ELSPBP1 Proteins)[1-40] (Dele12 for short) that have not been previously described. Insi1 represents an in-frame insertion of nucleotides 1-102 from intron 1, encoding a 34 amino acid insertion at amino acid 73.
TERT may promote gastric cancer metastasis through the TERT-miR (show MLXIP Proteins)-29a-ITGB1 (show ITGB1 Proteins) regulatory pathway.
TERT switches macrophages towards M1 phenotype by regulating NF-kappaB (show NFKB1 Proteins) signaling, but has limited effect on M2 macrophages polarization in vitro.
miR (show MLXIP Proteins)-195 overexpressed in old mesenchymal stem cells (OMSCs) induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase (Tert), and abrogation of miR (show MLXIP Proteins)-195 can reverse stem cell aging.
findings identified a key role for TERT in fibroblast proliferation and survival essential for pulmonary fibrosis
miR (show MLXIP Proteins)-512-5p suppresses tumor growth by targeting TERT in telomerase positive head and neck squamous cell carcinoma in vitro and in vivo.
data suggest that S1P (show S1PR1 Proteins) binding to hTERT allosterically mimicks phosphorylation, promoting telomerase stability and hence telomere maintenance, cell proliferation, and tumor growth.
Telomere shortening is more rapid in fas (show FASN Proteins) tert double mutants than in fas1 (show FAS Proteins), fas2 or tert single mutant plants.
Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
study reports the physical interaction of an Arabidopsis POT1 (show POT1 Proteins) protein, POT1A (show POT1 Proteins) (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant
AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 (show DKC1 Proteins) associates with active telomerase RNP (show RNPC3 Proteins) particles in an RNA-dependent manner.
Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified\; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Telomerase Reverse Transcriptase family member (trt-1)
, telomerase reverse transcriptase
, hypothetical protein
, Telomerase catalytic subunit
, telomerase catalytic subunit
, telomerase-associated protein 2
, telomerase reverse transcriptase beta