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trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase
methylation status of the genes of telomerase reverse transcriptase (tert) and telomerase RNA (terc) was determined in brain tissues; study found that, regardless of the age of fish, the regulatory region of the tert gene was completely methylated, whereas the coding region remained unmethylated
Telomerase-deficient zebrafish show p53 (show TP53 Proteins)-dependent premature aging and reduced lifespan in the first generation.
These results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis.
Telomerase regulatory subunit Est3 in Candida species physically interacts with the TEN domain of TERT and telomeric DNA
Tert was cloned from testis. It is expresed in embryo and adult, mostly in gonad and brain. 2 splice variants and an antisense transcript were identified.
The Japanese medaka is a new vertebrate model for studying tert biology.
Copy number variations in TERT gene is associated with lung adenocarcinoma.
These findings are the first results of TERT allele distributions in the Turkish population and also provide increased understanding with respect to colorectal cancer etiology.
TERT RNA-Dependent RNA Polymerase generates short RNAs that are complementary to template RNAs and have 5'-triphosphorylated ends, which indicates de novo synthesis of the RNAs
Of 24 MCL (but no other lymphoid cancers), 8 had TERTp mutations: 2 homozygous and 6 heterozygous (7 C228T and 1 C250T), correlating with higher TERT transcription, mitochondrial DNA copy number, and IGHV mutational status in the neoplastic cells.
Our study suggests that telomerase (TERT)and telomere function may be essential for carcinogenesis of EGFRmut(+) non-small cell lung cancer
TERT rs2736098 polymorphism was significantly associated with increased risk of gastrointestinal stromal tumors.
PPARgamma might inhibit the proliferation and migration of GC cell lines through suppressing the expression of TERT and ENAH
The data in this study provide preliminary evidence that TERT promoter mutations in combination with BRAF (show BRAF Proteins)/NRAS (show NRAS Proteins) mutations can be used to identify patients at risk of aggressive disease
With the advent of large-scale genome sequencing technology, molecular genetic alterations in TERT promoter have now been identified in the majority of oligodendrogliomas.
the prevalence and clinicopathological associations of BRAF (show BRAF Proteins) V600E and TERT promoter mutations in Chinese PTC (show F9 Proteins) patients
findings identified a key role for TERT in fibroblast proliferation and survival essential for pulmonary fibrosis
miR (show MLXIP Proteins)-512-5p suppresses tumor growth by targeting TERT in telomerase positive head and neck squamous cell carcinoma in vitro and in vivo.
data suggest that S1P (show S1PR1 Proteins) binding to hTERT allosterically mimicks phosphorylation, promoting telomerase stability and hence telomere maintenance, cell proliferation, and tumor growth.
Telomerase may direct Pol I transcription in oncogenic and regenerative hyperproliferation.
Tert expression confers cardioprotection in the adult mouse heart after acute myocardial infarction.
TERT is a regulator of MYC (show MYC Proteins) stability in cancer. Reactivation of TERT, a direct transcriptional MYC (show MYC Proteins) target in tumors, provides a feed-forward mechanism to potentiate MYC (show MYC Proteins)-dependent oncogenesis.
Pharmacologically relevant doses of atorvastatin resulted in a 6-fold increase of telomerase activity in mouse PBMCs and CD4 (show CD4 Proteins) T cells. Transgenic GFP-mTert reporter mice had 30% to 15% less telomerase-positive lymphocytes during the first 5 months of age.
Studies indicate that reverse transcriptase (RT) enzyme highly expressed in mouse embryos and mouse and human cancer cells and repressed in somatic differentiated healthy cells.
The overexpression of Zfp637 (show ZNF32 Proteins) markedly increases mTERT expression and telomerase activity, maintains telomere length, and inhibits H2O2 and D-galactose-induced senescence.
TERT, combined with beta-catenin (show CTNNB1 Proteins) and BRG1 (show SMARCA4 Proteins), serves as a transcriptional complex, which binds the FAS ligand (FASL (show FASL Proteins)) promoter to upregulate FASL (show FASL Proteins) expression, leading to an elevated immunomodulatory function.
Telomere shortening is more rapid in fas (show FASN Proteins) tert double mutants than in fas1 (show FAS Proteins), fas2 or tert single mutant plants.
Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
study reports the physical interaction of an Arabidopsis POT1 (show POT1 Proteins) protein, POT1A (show POT1 Proteins) (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant
AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 (show DKC1 Proteins) associates with active telomerase RNP (show RNPC3 Proteins) particles in an RNA-dependent manner.
Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified\; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Telomerase Reverse Transcriptase family member (trt-1)
, telomerase reverse transcriptase
, hypothetical protein
, Telomerase catalytic subunit
, telomerase catalytic subunit
, telomerase-associated protein 2
, telomerase reverse transcriptase beta