Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
In addition to thyroid hormonogenesis, the DUOX2 N-terminal domain may play a role in thyroid development.
This study reports the pedigree with goitrous congenital hypothyroidism (GCH (show GCH1 Proteins)) due to the coexistence of heterozygous mutations in the DUOX2 and DUOXA2 (show DUOXA2 Proteins) genes.
DUOX2 nonsense mutation plays a role in the pathogenesis of congenital hypothyroidism.
Expression of DUOX2 mRNA and protein was lower in gastric mucosa of patients with H. pylori infection compared to the uninfected. Among the H. pylori-infected patients, those having CagA (show S100A8 Proteins) IgG or VacA in the serum had lower DUOX2 expression levels than those infected with H. pylori without either virulence factor.
xome sequencing identified candidate variants, including a missense mutation in DUOX2 that impaired its function and a frameshift mutation in CSF2RB (show CSF2RB Proteins) that was associated with Crohn's Disease in an independent cohort of Ashkenazi Jewish individuals.
Data suggest that mutations in DUOX2 may be the most common cause of both permanent congenital hypothyroidism and transient hypothyroidism; severity of disease due to DUOX2 mutations may be milder than that due to other causes. This study involved neonatal screening of 48 Japanese boys and girls.
DUOX2 Mutation is associated with Congenital Hypothyroidism.
Nox4 (show NOX4 Proteins) and Duox1/Duox2 (show DUOX1 Proteins) mediate redox activation of mesenchymal cell migration by PDGF (show PDGFA Proteins).
The high prevalence of DUOX2 mutations in this cohort of children with Congenial hypothyroidism appears striking and surprising. The clinical implications were discussed.
study expanded the mutational spectrum of the DUOX2 and thyroglobulin (show TG Proteins) genes and provided the best estimation of the DUOX2 mutation rate (29%) for congenital hypothyroidism/subclinical congenital hypothyroidism patients in Guangxi Zhuang Autonomous Region of China
A novel recessive c.1226A>G transition of the dual oxidase 2 gene was identified as the causative mutation for a severe congenital hypothyroidism model together with anemia and T lymphopenia which mimics the clinical features of hypothyroid patients
the dual oxidase 2 N-terminal region is targeted to the plasma membrane
Both Nox1 (show NOX1 Proteins) and Duox2 (show DUOX1 Proteins) induce exfoliation of crypt epithelium, but only Nox1 (show NOX1 Proteins) induces apoptosis. NOX1 (show NOX1 Proteins) and DUOX2 (show DUOX1 Proteins) may be potential therapeutic targets for treating ileocolitis in human patients suffering inflammatory bowel disease (IBD).
dual oxidase-2 (show DUOX1 Proteins) and IL-6 (show IL6 Proteins) play important roles in GPR43 (show FFAR2 Proteins)-mediated skin inflammation.
We propose that Duox2 (show DUOX1 Proteins) is responsible for IFN-independent signaling for induction of pattern recognition receptors transcription and can control acute Influenza virus A infection at the beginning of infection.
DUOX2 (show DUOX1 Proteins) regulates interactions between the intestinal microbiota and the mucosa to maintain immune homeostasis in mice.
these data indicate that the gut (show GUSB Proteins) microbiota uses two distinct signaling pathways to induce Duox2 (show DUOX1 Proteins) expression in the ileum and colon epithelium.
Data suggest that proteinase-activated receptor 2 (show F2RL1 Proteins) activation leads to up-regulation of the dual oxidase-2 (show DUOX1 Proteins)/reactive oxygen species pathway in airway epithelial cells (AECs).
DUOX2 (show DUOX1 Proteins)-generated ROS (show ROS1 Proteins) induce AEC death.
a spontaneously generated valine 674-to-glycine mutation of murine Duox2 (show DUOX1 Proteins) results in a translocation defect and complete loss of function that explains the severe congenital hypothyroid phenotype of the thyd/thyd mouse strain
DUOX2 (show DUOX1 Proteins) plays pivotal roles in TLR5 (show TLR5 Proteins)-dependent inflammatory response of nasal airway epithelium.
DUOX2 and NOD2 cooperatively facilitate antibacterial action.
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain.
dual oxidase 2
, dual oxidase 2-like
, NADH/NADPH thyroid oxidase p138-tox
, NADPH oxidase/peroxidase DUOX2
, NADPH thyroid oxidase 2
, dual oxidase-like domains 2
, flavoprotein NADPH oxidase
, large NOX 2
, long NOX 2
, nicotinamide adenine dinucleotide phosphate oxidase
, p138 thyroid oxidase
, thyroid oxidase 2
, NADH/NADPH thyroid oxidase THOX2