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Browse our DUOX2 Proteins (DUOX2)

Full name:
Dual Oxidase 2 Proteins (DUOX2)
On www.antibodies-online.com are 5 Dual Oxidase 2 (DUOX2) Proteins from 2 different suppliers available. Additionally we are shipping DUOX2 Antibodies (37) and DUOX2 Kits (16) and many more products for this protein. A total of 59 DUOX2 products are currently listed.
Synonyms:
A430065P05Rik, LNOX2, NOXEF2, P138-TOX, TDH6, Thox2
list all proteins Gene Name GeneID UniProt
DUOX2 50506 Q9NRD8
Mouse DUOX2 DUOX2 214593  
DUOX2 79107 Q9ES45

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DUOX2 Proteins (DUOX2) by Origin

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Human Dual Oxidase 2 (DUOX2) interaction partners

  1. Expression of DUOX2 mRNA and protein was lower in gastric mucosa of patients with H. pylori infection compared to the uninfected. Among the H. pylori-infected patients, those having CagA (show S100A8 Proteins) IgG or VacA in the serum had lower DUOX2 expression levels than those infected with H. pylori without either virulence factor.

  2. xome sequencing identified candidate variants, including a missense mutation in DUOX2 that impaired its function and a frameshift mutation in CSF2RB (show CSF2RB Proteins) that was associated with Crohn's Disease in an independent cohort of Ashkenazi Jewish individuals.

  3. Data suggest that mutations in DUOX2 may be the most common cause of both permanent congenital hypothyroidism and transient hypothyroidism; severity of disease due to DUOX2 mutations may be milder than that due to other causes. This study involved neonatal screening of 48 Japanese boys and girls.

  4. DUOX2 Mutation is associated with Congenital Hypothyroidism.

  5. Nox4 (show NOX4 Proteins) and Duox1/Duox2 (show DUOX1 Proteins) mediate redox activation of mesenchymal cell migration by PDGF (show PDGFA Proteins).

  6. The high prevalence of DUOX2 mutations in this cohort of children with Congenial hypothyroidism appears striking and surprising. The clinical implications were discussed.

  7. study expanded the mutational spectrum of the DUOX2 and thyroglobulin (show TG Proteins) genes and provided the best estimation of the DUOX2 mutation rate (29%) for congenital hypothyroidism/subclinical congenital hypothyroidism patients in Guangxi Zhuang Autonomous Region of China

  8. Seven different recurrent mutations [p.G488R (n=13), p.A649E (n=3), p.R885Q (n=3), p.I1080T (n=2), and p.A1206T (n=2) in DUOX2; p.Y138X (n=9) in DUOXA2 (show DUOXA2 Proteins)) were identified as the mutations underlying congenital hypothyroidism.

  9. Transient congenital hypothyroidism is caused by compound heterozygous mutations affecting the NADPH-oxidase (show NOX1 Proteins) domain of DUOX2.

  10. the house dust mite-dependent TLR2-Duox2 signalling axis promotes NF-kappaB (show NFKB1 Proteins) activation, which induces IL-8 (show IL8 Proteins) and CCL20 (show CCL20 Proteins) production and mediates epidermal keratinocyte inflammation

Pig (Porcine) Dual Oxidase 2 (DUOX2) interaction partners

  1. the dual oxidase 2 N-terminal region is targeted to the plasma membrane

Mouse (Murine) Dual Oxidase 2 (DUOX2) interaction partners

  1. DUOX2 (show DUOX1 Proteins) regulates interactions between the intestinal microbiota and the mucosa to maintain immune homeostasis in mice.

  2. these data indicate that the gut (show GUSB Proteins) microbiota uses two distinct signaling pathways to induce Duox2 (show DUOX1 Proteins) expression in the ileum and colon epithelium.

  3. Data suggest that proteinase-activated receptor 2 (show F2RL1 Proteins) activation leads to up-regulation of the dual oxidase-2 (show DUOX1 Proteins)/reactive oxygen species pathway in airway epithelial cells (AECs).

  4. DUOX2 (show DUOX1 Proteins)-generated ROS (show ROS1 Proteins) induce AEC death.

  5. a spontaneously generated valine 674-to-glycine mutation of murine Duox2 (show DUOX1 Proteins) results in a translocation defect and complete loss of function that explains the severe congenital hypothyroid phenotype of the thyd/thyd mouse strain

  6. DUOX2 (show DUOX1 Proteins) plays pivotal roles in TLR5 (show TLR5 Proteins)-dependent inflammatory response of nasal airway epithelium.

  7. DUOX2 and NOD2 cooperatively facilitate antibacterial action.

DUOX2 Protein Profile

Protein Summary

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain.

Alternative names and synonyms associated with DUOX2

  • dual oxidase 2 (DUOX2)
  • dual oxidase 2 (Duox2)
  • A430065P05Rik protein
  • LNOX2 protein
  • NOXEF2 protein
  • P138-TOX protein
  • TDH6 protein
  • Thox2 protein

Protein level used designations for Dual Oxidase 2 Proteins (DUOX2)

dual oxidase 2 , dual oxidase 2-like , NADH/NADPH thyroid oxidase p138-tox , NADPH oxidase/peroxidase DUOX2 , NADPH thyroid oxidase 2 , dual oxidase-like domains 2 , flavoprotein NADPH oxidase , large NOX 2 , long NOX 2 , nicotinamide adenine dinucleotide phosphate oxidase , p138 thyroid oxidase , thyroid oxidase 2 , NADH/NADPH thyroid oxidase THOX2

GENE ID SPECIES
100070566 Equus caballus
427482 Gallus gallus
453395 Pan troglodytes
785698 Bos taurus
100445893 Pongo abelii
100462743 Ovis aries
50506 Homo sapiens
403719 Canis lupus familiaris
397060 Sus scrofa
214593 Mus musculus
79107 Rattus norvegicus
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