Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human PAX8 Antibodies:
anti-Rat (Rattus) PAX8 Antibodies:
anti-Mouse (Murine) PAX8 Antibodies:
Go to our pre-filtered search.
Human Polyclonal PAX8 Primary Antibody for ChIP, ICC - ABIN442408
Elias, Emori, Westerling, Long, Budina-Kolomets, Li, MacDuffie, Davis, Holman, Lawney, Freedman, Quackenbush, Brown, Drapkin: Epigenetic remodeling regulates transcriptional changes between ovarian cancer and benign precursors. in JCI insight 2016
Show all 3 Pubmed References
Human Monoclonal PAX8 Primary Antibody for ELISA, WB - ABIN966806
Chia, Sharifah, Reena, Zubaidah, Clarence-Ko, Rohaizak, Naqiyah, Srijit, Hisham, Asmiati, Rafie: Fluorescence in situ hybridization analysis using PAX8- and PPARG-specific probes reveals the presence of PAX8-PPARG translocation and 3p25 aneusomy in follicular thyroid neoplasms. in Cancer genetics and cytogenetics 2009
Show all 3 Pubmed References
Human Polyclonal PAX8 Primary Antibody for ELISA, WB - ABIN252940
Castro, Rebocho, Soares, Magalhães, Roque, Trovisco, Vieira de Castro, Cardoso-de-Oliveira, Fonseca, Soares, Sobrinho-Simões: PAX8-PPARgamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma. in The Journal of clinical endocrinology and metabolism 2006
Human Polyclonal PAX8 Primary Antibody for IHC (p), IHC - ABIN249584
Pasca di Magliano, Di Lauro, Zannini: Pax8 has a key role in thyroid cell differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2000
Human Monoclonal PAX8 Primary Antibody for ELISA, WB - ABIN969343
McKnight, Cohen, Siddiqui: Utility of paired box gene 8 (PAX8) expression in fluid and fine-needle aspiration cytology: an immunohistochemical study of metastatic ovarian serous carcinoma. in Cancer cytopathology 2010
Human Polyclonal PAX8 Primary Antibody for IHC (p), WB - ABIN374237
Borgogni, Sarchielli, Sottili, Santarlasci, Cosmi, Gelmini, Lombardi, Cantini, Perigli, Luconi, Vannelli, Annunziato, Adorini, Serio, Crescioli: Elocalcitol inhibits inflammatory responses in human thyroid cells and T cells. in Endocrinology 2008
Show all 2 Pubmed References
Cow (Bovine) Polyclonal PAX8 Primary Antibody for IHC, WB - ABIN2783221
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006
Show all 2 Pubmed References
PAX8 has a cell specific role in governing proliferation and migration in nontransformed ovarian surface epithelium cells compared to the oviductal cells, but its reduction in serous cancer cell lines provides a common mechanism for reducing cell survival.
findings proved that iodinated TG in thyroid follicular lumen regulated TTF-1 and PAX8 expression through thyroid stimulating hormone/thyroid stimulating hormone receptor (TSH/TSHR) mediated cAMP-PKA and PLC-PKC signaling pathways.
Case Report: primary seminal vesicle carcinoma strong and diffuse nuclear labeling for PAX8.
PAX8 is expressed in both benign and malignant mesothelium, and that BAP1 (show RNF2 Antibodies) loss is highly specific for malignant peritoneal neoplasms, in the differential with both benign mesothelial proliferations and ovarian serous tumors.
findings point to significant PTC (show F9 Antibodies)-associated dysregulation of several PAX8 target genes, supporting the notion that PAX8-regulated molecular cascades play important roles during thyroid tumorigenesis
we replicated one known signal in PAX8 (2.6 minutes per allele, 95% CI [1.9, 3.2], P = 5.7x10-16) and identified and replicated two novel associations at VRK2 (show VRK2 Antibodies) (2.0 minutes per allele, 95% CI [1.3, 2.7], P = 1.2x10-9; and 1.6 minutes per allele, 95% CI [1.1, 2.2], P = 7.6x10-9)
Putative PAX8 target genes are enriched for common serous epithelial ovarian cancer risk variants.
We conclude that PAX8 immunostain is negative in most cervical cell carcinomas and is less frequently expressed in endocervical adenocarcinomas as compared with the previously reported high sensitivity for ovarian and endometrial adenocarcinomas
Study postulated that both TTF-1 (show NKX2-1 Antibodies) and PAX-8 when co-expressed and have anti-proliferative and anti-tumorigenic properties up to a threshold expression level and beyond that, are able to induce pro-tumorigenic effects in thyroid carcinomas.
Direct sequencing of the PAX8 gene revealed a novel single nucleotide substitution (c.162 A>T) in exon 2 that resulted in the substitution of the normal serine 54 with a cysteine (S54C), which segregated with elevated serum TSH levels.
Pax8 is required for cell proliferation of pronephric precursors and regulates the expression of hnf1b (show HNF1B Antibodies) and wnt (show WNT2 Antibodies) pathway genes in the kidney field.
nephrogenic transcription factors (osr1 (show OSR1 Antibodies), osr2, hnf1b (show HNF1B Antibodies), lhx1 (show LHX1 Antibodies), pax8)play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A (show INHBA Antibodies), retinoic acid
These results suggest that Pax8 maybe the downstream molecule of ALK3 (show BMPR1A Antibodies), it mediates the murine heart development via cellular senescence, which may serve as a mechanism that compensates for the cell loss via apoptosis in heart development.
Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure
PAX8 protein expression was associated with germinal layers in human and murine forebrain and hindbrain development.
Pax8 is essential for function and survival of adult thyroid cells.
a core regulatory subcircuit composed of Pax2 (show PAX2 Antibodies)/8, Gata3 (show GATA3 Antibodies) and Lim1 (show LHX1 Antibodies) turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization.
The Pax8 promoter appears to be autoregulated, a feature that might be responsible for the haploinsufficiency displayed by this gene.
Inducible, Pax8-rtTA-based deletion of VHL (show VHL Antibodies) leads to organ-specific expression of epithelial HIF and erythropoietin (show EPO Antibodies) in liver and kidney without causing pathological changes.
study concludes that Cadherin-16 (show CDH16 Antibodies) is a novel downstream target of the transcription factor Pax8, likely since the early steps of thyroid development, and that its expression is associated with the fully differentiated state of the thyroid cell
a thyroid-specific regulatory element in the 5' upstream region of the Pax8 gene
Pax2a and Pax8 regulate cell differentiation during sensory placode formation
pax8 works with related genes pax2a/pax2b to downregulate otic expression of foxi1 (show FOXI1 Antibodies), a necessary step for further otic development
evolutionary links between jaw and ear formation can be traced to Fgf-Foxi1 (show FOXI1 Antibodies)-Pax8 pathways
Pax2a and Pax8 are the main effectors downstream of Fgf signals in ear formation
pax8 is initially required for normal otic induction, and subsequently pax8, pax2a and pax2b act redundantly to maintain otic fate
This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.
paired box 8
, paired box gene 8
, paired box protein Pax-8
, paired domain gene 8
, Pax-8 protein
, Pax-8 DNA-binding transcription factor