Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human CD14 Protein expressed in Wheat germ - ABIN1348531
Gu, Werner, Bergmann, Whitcomb, Büchler, Fortunato: Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis. in Cell death & disease 2013
Data (including data from studies conducted in cells from knockout mice) suggest that signaling via Lpar1 (show LPAR1 Proteins), Cd14, and Scara1 (show MSR1 Proteins) mediates uptake of oxidized LDL by macrophages leading to foam cell formation; lysophosphatidic acid (LPA) induces expression of Cd14 and Scara1 (show MSR1 Proteins) in macrophages. (Lpar1 (show LPAR1 Proteins) = LPA receptor 1 (show LPAR1 Proteins); Cd14 = monocyte differentiation antigen CD14; Scara1 (show MSR1 Proteins) = scavenger receptor class A type I)
Stimul (show TLR4 Proteins)ation of murine peritoneal macrophages with LPS indu (show TLR4 Proteins)ces biphasic accumulation of PI(4,5)P2 with peaks at 10 and 60-90 min that was abrogated when C (show TLR4 Proteins)D14 was removed from the cell surface.
these results indicate that CD14 is a co-receptor of TLR4 (show TLR4 Proteins) in the S100A9 (show S100A9 Proteins)-induced cytokine response.
this study shows that lipid rafts may serve as sites in which LPS (show TLR4 Proteins) receptors (CD14) are sorted for endocytosis, rather than being platforms for the assembly of TLR4 (show TLR4 Proteins)-centered signaling complexes
These findings suggested that the degree of lung injury was reduced during the acute inflammatory reaction when NFkappaB was inhibited, and that the expression of sphingomyelin synthase 2 (show SGMS2 Proteins) may affect the induction of the NFkappaB pathway by lipopolysaccharide through CD14.
Results demonstrate remarkable sophistication of microglial CD14 in enabling, facilitating and moderating innate immune responses to infectious and non-infectious CNS threats of diverse kinds
CD14-mediated lipid signaling induced epithelial apoptosis, whereas TLR4 (show TLR4 Proteins) antagonistically promoted cell survival and cancer development.
fucosyllactose directly inhibits lipopolysaccharide-mediated inflammation during E. coli infection of intestinal epithelial cells through attenuation of CD14 induction.
studies revealed a novel physical association between SP-R210S, CD14, and SR-A (show MSR1 Proteins) leading to an enhanced response to LPS (show TLR4 Proteins), and found that SP-R210L and SP-R210S regulate internalization of CD14 via distinct macropinocytosis-like mechanisms
Data indicate that Toll-like receptor 4 (TLR4 (show TLR4 Proteins)) endocytosis and the TIR-domain-containing adapter-inducing IFN-beta (show IFNB1 Proteins) (TRIF (show RNF138 Proteins))-signaling pathway in macrophages during endotoxin tolerance in the absence of cluster of differentiation 14 (CD14).
META-ANALYSIS: association between the -159C/T polymorphism in the promoter region of the CD14 (show NDUFA2 Proteins) gene and sepsis
In LPS (show IRF6 Proteins)-stimulated HEK293 cells with low CD14 (show NDUFA2 Proteins) and high TLR4 (show TLR4 Proteins), no accumulation of PI(4,5)P2 occurred. With an increasing amount of CD14 (show NDUFA2 Proteins) and decrease of TLR4 (show TLR4 Proteins), 2 peaks of PI(4,5)P2 appeared, approaching those found in LPS (show IRF6 Proteins)-stimulated cells expressing CD14 (show NDUFA2 Proteins) alone. This suggests that LPS (show IRF6 Proteins)-induced accumulation of PI(4,5)P2 that maximizes TLR4 (show TLR4 Proteins) signaling is controlled by CD14 (show NDUFA2 Proteins), whereas TLR4 (show TLR4 Proteins) can fine tune this via PI(4,5)P2 turnover.
Intermediate CD14 (show NDUFA2 Proteins)++CD16 (show CD16 Proteins)+monocytes might be closely related to the pathogenesis of atrial fibrillation and reflect functional remodelling of the left atrium.
In 121 primary sclerosing cholangitis patients, the CD14 (show NDUFA2 Proteins) -260C>T genotype was associated with development of dominant bile duct strictures (P = 0.02). In 365 liver transplantation patients, TT carriers (4.1%) were protected against the formation of nonanastomotic biliary strictures versus CC/CT patients (12.6%; P = 0.01).
response of hPdLSCs to bacterial LPS (show IRF6 Proteins) is strongly augmented by sCD14
analysis of plasma CXCL10 (show CXCL10 Proteins), sCD163 (show CD163 Proteins) and sCD14 in virological suppression and risk of cardiovascular disease
TGM2 (show TGM2 Proteins) has a role in macrophage differentiation via mechanisms involving CD14 (show NDUFA2 Proteins) and SR-AI (show MSR1 Proteins) receptors.
we found that higher percentages of circulating CD14 (show NDUFA2 Proteins)+CD204+, CD14 (show NDUFA2 Proteins)+CD163 (show CD163 Proteins)+CD204+ M2-like monocytes were significantly associated with TNM (show ODZ1 Proteins) stage, lymph node metastasis, and histological differentiation.
these results indicate that CD14 (show NDUFA2 Proteins) is a co-receptor of TLR4 (show TLR4 Proteins) in the S100A9 (show S100A9 Proteins)-induced cytokine response.
our data showed the contribution on the TLR4 (show TLR4 Proteins)+896A/G and CD14 (show NDUFA2 Proteins)-159C/T polymorphism-related immune dysfunction including increased non-classical (inflammatory) monocyte proportion-related LPS (show IRF6 Proteins) hyper-inflammatory response and decreased classical (phagocytic) monocyte proportion-related impaired phagocytosis in febrile acute de-compensated cirrhotic patients complicated with severe sepsis.
Transcription levels of TLR2, TLR4 (show TLR4 Proteins), and CD14 in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
Data from an in vitro co-culture model suggest that an early response of endometrium in uterine infection is up-regulation of expression of CD14 and TLR4 (toll-like receptor 4 (show TLR4 Proteins)).
This study study confirmed that expression of CD14 in blood polymorpnuclear cells (PMN (show TBCE Proteins)), resident PMN (show TBCE Proteins) and inflammatory PMN (show TBCE Proteins) from heifer mammary glands was accompanied by apoptosis and necrosis.
data are consistent with a role for lipopolysaccharide binding protein (show LBP Proteins) and soluble CD14 antigen molecules in mediating mammary gland responses to lipopolysaccharide(lipopolysaccharide binding protein- LBP (show LBP Proteins))
Toll-like receptor 4 (show TLR4 Proteins) mRNA and CD14 mRNA and protein were detected in bovine endometrial stromal and epithelial cells by RT-PCR and flow cytometry.
SNP and association analyses have provided baseline information that may be used at defining the role of CD14 in mediating bacterial infections
VB-201 may counter inflammation where TLR-2 and/or CD14 complicity is essential, and is therefore beneficial for the treatment of atherosclerosis.
Determine native soluble CD14 concentrations in serum from healthy and septic foals, in the colostrum of healthy mares and in plasma from adult horses with recurrent airway obstruction and control horses.
CD14 mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein.
monocyte differentiation antigen CD14
, myeloid cell-specific leucine-rich glycoprotein
, CD14 antigen
, lipopolysaccharide receptor